q-bio papers | Gist.Science

Exploring the prognostic value of N4-acetylcytosine- modified genes in colorectal cancer using transcriptomics combined with single-cell data

This study integrates bulk and single-cell transcriptomics to identify a seven-gene N4-acetylcytosine modification-related signature that effectively stratifies colorectal cancer patients into high- and low-risk groups while revealing distinct immune infiltration patterns, pathway enrichments, and key cellular differentiation trajectories to guide potential therapeutic strategies.

Rui Du, Tao Hu, Xianglei Jin, Qiang Yuan, Chengwu Jin, Xiaodong Wang, Mingtian Wei, Xuyang Yang, Mingming Zhang, Li Li (…)2026-07-10

🧬 biology

Comparative Molecular Docking and ADMET Profiling of Five Clinically Approved DPP-4 Inhibitors: Structural Insights into Binding Affinity and Interaction Diversity

This study presents an integrated computational analysis of five approved DPP-4 inhibitors, revealing that sitagliptin and linagliptin exhibit the strongest predicted non-covalent binding affinities while highlighting methodological limitations in docking covalent inhibitors and providing a validated framework for future drug design.

SanchitKumar Rai, Adharsh Kirtan2026-07-10

🧬 biology

PathwayBench: a multi-criterion benchmark of pseudobulk pathway activity scoring methods reveals rank-window competition as a mechanism of biological signal loss in single-cell RNA-seq

PathwayBench introduces a comprehensive multi-criterion benchmark revealing that "rank-window competition" causes biological signal loss and direction inversion in rank-based pathway scoring methods, thereby guiding evidence-based method selection for pseudobulk single-cell RNA-seq analyses.

Fadhl M. Alakwaa¹, Ahmed Elbaz², Sara Al Azzam³, Tasnim Alshebani⁴2026-07-10

🧬 biology

Biochemical efficacy in the inhibition of oxidative stress mediated by Enterococcus faecium and Streptococcus bovis isolated from the intestinal microbiota

This study demonstrates that specific isolates of *Enterococcus faecium* and *Streptococcus bovis* from healthy human gut microbiota exhibit synergistic biofilm formation and significant antioxidant, iron-chelating, and anti-lipid peroxidation activities, highlighting their potential as probiotics for mitigating oxidative stress.

Bachir Bourroubey2026-07-10

🧬 biology

Adaptive executive control indexed by frontal theta/beta dynamics and trial-level EEG during ecologically valid tasks in schizophrenia

This study demonstrates that individuals with schizophrenia exhibit impaired adaptive executive control during ecologically valid tasks, characterized by elevated baseline frontal theta/beta ratios and reduced trial-level EEG modulation compared to healthy controls.

Winai Chatthong, Maliwan Rueankam, Supalak Khemthong2026-07-10

🧬 biology

Flagellar Oncogenicity in the Hypocomplement–Tumour Holobiont: A Five-Prediction Hypothesis Paper on Bacterial Flagella as Effectors of Virus-Driven and Coinfection-Driven Carcinogenesis

This hypothesis paper proposes that bacterial flagella serve as the primary effectors of viral and coinfection-driven carcinogenesis within the tumor microbiome by linking flagellar biology, complement evasion, and microbial dominance, and outlines five testable predictions plus a sixth extended hypothesis to guide future immuno-oncology research.

Shrish Chandra Srivastava2026-07-10

🧬 biology

Chronic Antigen Exposure and Immune Tolerance Dynamics: A Unified Treg–Tpex Phase Transition Framework

This paper proposes a unified phase-transition framework where chronic antigen exposure outcomes are governed by a tolerance stability index ( $S_i$ ) and a dynamic "immune tide," predicting abrupt shifts between tolerance and effector states across diverse clinical conditions through critical bifurcation dynamics.

Yuanshan Zhang2026-07-10

🧬 biology

The Aiko–Takeru (AT) Model: A Kidney-Level Flux–Balance Framework for Asymmetric PKD Progression

The Aiko–Takeru (AT) Model proposes a kidney-level flux–balance framework, derived from a longitudinal feline study with induced drainage asymmetry, suggesting that asymmetric polycystic kidney disease progression is driven by kidney-specific differences in drainage efficiency rather than systemic vasopressin exposure alone.

Naruhiko Nakanishi2026-07-10

🧬 biology

Modulation of layer II immature neurons in the neocortex of sheep kept in different environmental conditions

This study demonstrates that both stressful isolation and environmental enrichment significantly reduce the number of immature neurons in the neocortex of sheep compared to controls, likely by accelerating their maturation, thereby revealing that lifestyle factors can induce structural plasticity in the upper layers of gyrencephalic brains.

Luca Bonfanti2026-07-10

🧬 biology

Decoding Viral Signatures: Comparative Transcriptomics of SARS-CoV-2, Influenza A, and RSV Reveals Virus-Specific Host Responses

This study utilizes comparative transcriptomics of SARS-CoV-2, Influenza A, and RSV infections in human airway epithelial cells to reveal that these respiratory viruses elicit largely distinct, virus-specific host transcriptional responses with minimal shared gene signatures, suggesting a need for pathogen-targeted therapeutic and diagnostic strategies.

Oluwadamilola Sadiku2026-07-10✓ Author reviewed ⓘ

← Previous Next →