4404 papers
This paper presents an ATP-fueled enzymatic DNA reaction network that enables autonomous, site-confined, and pathway-selective transient signal transduction on DNA-nanostructure tracks, featuring an RNA-based input clearance mechanism for repeated programmable information processing in non-equilibrium nanodevices.
This study demonstrates that dual targeting of BCL-XL and MCL-1, rather than single-protein inhibition, triggers rapid, synergistic, and p53-independent mitochondrial apoptosis in the majority of non-small cell lung cancer cells, revealing a cooperative pro-survival network as a key therapeutic vulnerability.
This study introduces a novel fractal-fractional mathematical model to analyze the complex co-infection dynamics of monkeypox and typhoid fever, demonstrating that this advanced framework effectively captures memory effects and multi-scale heterogeneities to reveal how dual pathogen interactions accelerate disease progression and inform integrated control strategies.
This paper presents a unified analytical hydrodynamic model that explains bacterial transport in low-Reynolds-number flows by revealing how shear-induced depletion and alignment are dual manifestations of a single active phase-space topology, validated through experiments across multiple species and flow geometries.
This study establishes adenylosuccinate lyase (ADSL) as a critical prognostic biomarker and therapeutic target across multiple cancers, particularly glioma, by demonstrating its upregulation correlates with poor outcomes, elucidating its role in purine metabolism and tumor immunity, and validating GANT-58 as a promising ADSL inhibitor through both computational and experimental approaches.
This study demonstrates that human cortical astrocytes express the type 1 cannabinoid receptor (CB1R) at both mRNA and protein levels, suggesting that cannabinoids can directly activate these cells and potentially disrupt neuro-glia communication, thereby contributing to cognitive impairments associated with cannabis use.
This study demonstrates that fishers' Local Ecological Knowledge can effectively reconstruct the historical existence of a Caribbean coastal nursery area for six elasmobranch species in Bahía de la Ascensión over 30 years ago, providing a crucial baseline for conservation in data-poor contexts.
This study demonstrates that in the hoverfly genus *Platycheirus*, male reproductive traits exhibit significantly lower phylogenetic signal than morphological and female reproductive traits, suggesting they are less constrained by phylogeny due to strong sexual selection.
This study demonstrates that opioid use disorder is characterized by a blunted catecholaminergic modulation of the brain's hierarchical organization, where methylphenidate fails to compress the principal cortical gradient or improve visual attention in patients compared to healthy controls, suggesting a systems-level deficit linked to the severity and duration of opioid use.
This study integrates single-cell and spatial transcriptomics to reveal that while gastric cancer exhibits widespread transcriptional signatures of tertiary lymphoid structures (TLS), these structures rarely achieve spatial maturity, a deficit that co-occurs with T-cell exhaustion and immunosuppressive signaling, thereby explaining the limited efficacy of immune checkpoint blockade in this disease.