4413 papers
By recording intracranial thalamic activity in epilepsy patients, this study reveals that the human pulvinar exhibits distinct temporal dynamics, characterized by a dominant sustained response that supports prolonged attentional states, alongside a less frequent early transient response for rapid stimulus detection.
This study identifies a novel heterozygous gain-of-function missense variant in the NUAK2 gene as the cause of autosomal dominant congenital oculomotor apraxia and cerebellar vermis hypoplasia in a three-generation family, expanding the gene's known pathogenic mechanisms beyond previously reported loss-of-function variants.
This study found that, unlike external short-wave filters, the intrinsic short-wave filtering provided by macular pigment does not significantly enhance brightness perception in natural scenes, suggesting that the spatial extent of filtering across the retina is a critical factor in such effects.
This study reveals that cantharidin-induced nephrotoxicity is driven by the ectopic accumulation of LPC(16:0) in the renal cortex due to impaired lipid homeostasis and mitochondrial dysfunction, which synergistically exacerbates apoptosis via the SPHK1 pathway.
Using 12 years of capture-mark-recapture data, this study reveals that adult headwater stream salamanders exhibit context-dependent dispersal directionality, moving upstream in downstream reaches and downstream in upstream reaches to navigate risk landscapes, whereas their overall dispersal propensity remains consistent regardless of direction.
This study reports the first detection of Porcine Circovirus 2 (PCV2d) in a wild *Rattus norvegicus* in Malaysia, suggesting that wild rats may contribute to the environmental circulation of this swine pathogen.
The Genetics of DNA Methylation Consortium (GoDMC) has developed an expanded, community-driven software framework that standardizes cohort-level processing and enables reproducible, summary-statistics-based analyses integrating DNA methylation and genetic variation.
This study presents a novel hybrid machine learning framework combining LightGBM and PyTorch-based Attention mechanisms to accurately predict VBNC bacterial resuscitation, achieving superior performance over traditional methods and identifying nutrient concentration and cAMP signaling as key determinants for recovery.
The paper introduces Tabula, a privacy-preserving single-cell foundation model that leverages federated learning to explicitly capture the tabular structure of genomic data, enabling the discovery of regulatory logic and the identification of rejuvenation factors without sharing raw data across institutions.
This paper presents the Pacific eDNA Coastal Observatory, a cross-national network spanning 16 nodes from San Diego to Juneau that utilized 1,041 seawater samples over four years to generate a comprehensive, validated dataset of nearshore fish biodiversity across the Northeast Pacific, demonstrating the effectiveness of coordinated eDNA monitoring for large-scale comparative inference.