q-bio papers | Gist.Science

Large-Scale Reproduction of Alzheimer Research on aCommon Dataset Reveals an Information Ceiling on theField’s Evidence

By applying a novel AI-mediated framework (AHA) to reproduce and audit thousands of Alzheimer's disease studies on a common dataset, the authors demonstrate that while the field's reported predictive performance can be replicated at scale, the available data is fundamentally information-insufficient to distinguish between competing hypotheses, revealing a ceiling on the evidence that explains the field's divergent research trajectories.

M. Antony Ewing2026-07-09

🧬 biology

Behavioral, neurobiological, and physiological effects of music exposure in murine models: A systematic review

This systematic review of 65 murine studies concludes that music exposure significantly enhances behavioral, neurobiological, and physiological outcomes in rats, though methodological heterogeneity necessitates further standardized research to clarify mechanisms and confirm translational potential for humans.

Nour El Zahraa Mallah, Laura Navarro, Tomás Sobrino, Alberto Ouro, Federico Martinón-Torres, Alberto Gómez-Carballa, Ant (…)2026-07-09

🧬 biology

Structural Insights into Specific Recognition of mononucleosome by the catalytic domain of Human KMT5A

This study presents three high-resolution cryo-EM structures of the human SET8 catalytic domain bound to nucleosomes, revealing how specific arginine-mediated anchoring to the acidic patch and dynamic conformational transitions facilitate the recognition and monomethylation of histone H4 lysine 20.

Jingjun Hong2026-07-09✓ Author reviewed ⓘ

🧬 biology

The PRIDE Affinity-Proteomics Archive (PRIDE-AP): Making Affinity Proteomics Data FAIR

The paper introduces PRIDE-AP, a new FAIR-compliant, open-data repository within the PRIDE infrastructure that addresses the lack of a dedicated archive for high-throughput affinity proteomics by enabling standardized submission, validation, and cross-technology integration of datasets to accelerate biomarker discovery.

Deepti J. Kundu, Asier Larrea-Sebal, Selvakumar Kamatchinathan, Chakradhar Bandla, Nithu Sara John, Nandana Madhusoodana (…)2026-07-09

🧬 biology

Learning epidemics: a compartmental and network approach to how artificial intelligence literacy spreads inside organizations

This paper reframes the spread of artificial intelligence literacy within organizations as a contagion process, demonstrating through network epidemiology and machine learning that learning retention is primarily driven by structural communication network properties and an individual's position within them rather than just personal attributes.

Onicio Batista Leal Neto, Julia Nicolau, Alexandre Santilli2026-07-09

🧬 biology

WITHDRAWN: Circadian Clock-Gene Structure Couples with PD-L1 Across Six Cancer Types and Defines Survival-Associated Subtypes in Melanoma

This paper, which originally proposed a link between circadian clock-gene structure and PD-L1 across six cancer types to define melanoma subtypes, has been withdrawn by the author due to concerns regarding the accuracy, validity, and reliability of its content.

Moses Rahnama2026-07-09

🧬 biology

PRPF39-PRTF1 enforces splicing of short and GC-poor introns across metazoans

The study reveals that the conserved PRPF39/PRTF1 complex is essential for splicing difficult, short, and GC-poor introns across metazoans, with its loss causing distinct splicing defects (exon skipping in vertebrates and intron retention in invertebrates) and developmental abnormalities like wing duplication in flies.

Simon Bekker-Jensen, Laura Ryder2026-07-09

🧬 biology

CXCL12 Promotes Peripheral Nerve Repair by Enhancing Schwann Cell-Mediated Myelin Debris Clearance through CXCR4/HIF1A/BNIP3-Dependent Mitophagy

CXCL12 accelerates peripheral nerve repair by activating the CXCR4/HIF1A/BNIP3 signaling axis to induce mitophagy in Schwann cells, which restores mitochondrial function and enhances the clearance of myelin debris.

Ye Yuan, Ge Gao, Yu Jiang, Saisai Du, Guohong Yuan, Zhenjun Yang, Pei Wang2026-07-09

🧬 biology

Differential Alterations of Gut Microbiota in Girls with Isolated Obesity, Isolated Precocious Puberty, and Their Comorbidity

This study reveals that while isolated childhood obesity and precocious puberty in girls exhibit distinct gut microbiota alterations, their comorbidity presents a unique microbial profile characterized by a dramatic depletion of Firmicutes and a massive expansion of Verrucomicrobiota, suggesting a specific dysbiotic ecotype that may drive the pathophysiology of this condition.

Han Xuan, Hou Yangnan, Su Ganglin, Zhang Zhaoxia, Zhang qin, Dong guoqing, Luo xiaoping2026-07-09

🧬 biology

Temporal shift toward deterministic assembly shapes particle‑associated core microbiome for cooperative nitrogen metabolism in small-scale greenhouse shrimp aquaculture systems

In small-scale greenhouse shrimp aquaculture systems, the particle-associated microbiome undergoes a temporal shift from stochastic to deterministic assembly, fostering a functionally convergent and cooperative core consortium that ensures efficient nitrogen metabolism despite geographic variations in taxonomic composition.

Ni Liu, Zhiyuan Yan, Yuxing Xie, Hao Long, Xiaoni Cai, Aiyou Huang, Yanhua Zeng, Zhenyu Xie2026-07-09

← Previous Next →