4413 papers
This study identifies WNT11 as a TGFβ- and canonical WNT/β-catenin-dependent feedback inhibitor that restricts mesenchymal stem cell chondrogenesis via noncanonical pathways, thereby acting as a gatekeeper that limits SOX9 activity to facilitate progression toward chondrocyte hypertrophy.
This study presents the first comparative genomic analysis of *Burkholderia pseudomallei* isolates from Bangladesh, revealing that while core virulence systems are conserved, clinical outcomes may be influenced by distributed functional mutations in regulatory and stress-response pathways rather than a single dominant virulence determinant.
This study demonstrates that Sophora davidii flower (SDF) exerts anti-aging effects on HUVECs by inhibiting senescence and enhancing tube formation through the dose-dependent regulation of the TP53-PI3K/AKT signaling pathway, as revealed by network pharmacology and experimental validation.
This study identifies SCP2 as a novel independent prognostic and immunological biomarker for colorectal cancer, demonstrating that its downregulation correlates with poor clinical outcomes, advanced disease stages, an immunosuppressive microenvironment, and enhanced tumor cell proliferation.
By utilizing activity sensor data to track oestrus in wild European roe deer, this study reveals that mating is highly synchronized and largely independent of individual traits, suggesting that reproductive phenology is primarily driven by the timing of delayed implantation rather than conception dates.
This study characterizes the distinct mucosa-associated microbial profiles of North Indian patients with ulcerative colitis, revealing a unique dysbiosis marked by an elevated Firmicutes-to-Bacteroidota ratio, specific taxonomic shifts, and altered microbial interaction networks compared to healthy controls.
This study demonstrates that the repurposed drugs desloratadine and zinc gluconate act as effective efflux pump inhibitors that synergize with erythromycin to restore its efficacy against multidrug-resistant bacteria both in vitro and in a mouse model, a mechanism further validated by molecular docking and simulation studies targeting the AbeJ protein.
This study reveals a significant shared genetic architecture between cataract and major depressive disorder (MDD), characterized by 32 overlapping loci and five candidate genes, suggesting their association stems from pleiotropy rather than a direct causal relationship.
This study identifies a 14-gene Mitoxyperilysis-related signature that independently predicts prognosis in breast cancer by characterizing a distinct tumor microenvironment state marked by innate immune remodeling, myeloid enrichment, and suppressed programmed cell death.
The paper introduces "Spotted," a human-in-the-loop framework that enhances animal re-identification in camera trap surveys by integrating visual similarity with spatio-temporal feasibility priors, significantly improving accuracy for hyenas and leopards while reducing the expert review burden.