4413 papers
This comparative cohort study reveals that non-traumatic osteonecrosis of the femoral head (ONFH) is characterized by a unique gut dysbiosis marked by Bacteroidetes dominance and excessive ecological connectivity, distinct from traumatic fractures and potentially driven by the translocation of oral microbiota such as *Segatella*.
This study reveals that adolescents with ADHD exhibit altered spatiotemporal neural processing of emotional facial distractors, characterized by specific ERP abnormalities from early perceptual to later attentional stages, which are partially modulated by psychostimulant treatment.
A four-year evaluation of the UCSF CFAR Scholars Program demonstrates that a structured, mentored research pathway for pre-doctoral students from underrepresented backgrounds significantly enhances research readiness, scientific identity, and interest in HIV careers, supporting early intervention as an effective strategy to diversify the biomedical workforce.
This prospective study of 82 cancer patients reveals that elevated baseline frequencies of circulating CD5⁺ conventional dendritic cells type 2, driven by a specific gut microbiome metabolic output, independently predict clinical benefit from immune checkpoint inhibitors, while a distinct oral microbiome signature forecasts severe adverse events.
This study identifies a distinct malignant subpopulation in hepatocellular carcinoma driven by an RBM8A/HDAC9/p16 axis, where RBM8A stabilizes HDAC9 mRNA to epigenetically silence p16, thereby promoting early tumor recurrence and chemoresistance.
This study characterizes the high prevalence of strong biofilm formation among circulating *Bordetella pertussis* isolates in Beijing and utilizes GWAS to reveal that this phenotypic heterogeneity is driven by coordinated genomic remodeling across multiple biological pathways rather than single genetic determinants.
This study demonstrates that reports of fungi synthesizing isoflavones are likely artifacts caused by plant-derived contaminants in culture media, as fungal genomes lack the necessary enzymatic machinery for isoflavone biosynthesis despite possessing the ability to produce simpler flavonoids via distinct evolutionary pathways.
This study reveals that dietary protein sources (pork and soy) exacerbate obesity and hepatic insulin resistance in obesogenic conditions by elevating carnitine levels, which downregulate ACC2 and alter mitochondrial lipid handling, whereas casein protein does not produce these adverse effects.
This study demonstrates that ZNF114 acts as an oncogenic driver in gastric cancer by promoting epithelial–mesenchymal transition and establishing an immunosuppressive tumor microenvironment, thereby correlating with poor patient prognosis and serving as a potential therapeutic target.
This genome-wide association study identifies both established and novel genetic variants that significantly modulate cerebrospinal fluid, plasma, and urine biomarkers in α-synucleinopathies, highlighting the critical need to account for genetic background when interpreting these biomarkers for diagnosis and therapeutic development.