🧬 Category

q-bio

4413 papers

🧬 biology

Distinct macrophage- and cardiomyocyte-associated inflammatory signatures in forensic autopsy hearts with acute ischemic heart disease

This study demonstrates that analyzing the distinct, cell-type-specific inflammatory signatures of macrophage-derived osteopontin and cardiomyocyte-derived NLRP3 in forensic autopsy hearts provides valuable insights into the inflammatory microenvironment of acute ischemic heart disease, potentially aiding the diagnosis of sudden death cases with subtle pathological findings.

Yumi Kuninaka, Yuko Ishida, Stefano Palumbi, Mizuho Nosaka, Hiroki Yamamoto, Etsu Wakita, Miyu Osako, Wei Zhang, Reiko M (…)2026-07-08
🧬 biology

Evaluation of a Recombinant Multi-Epitope Sperm Protein Vaccine for Immunocontraception in Female Mice

This study demonstrates that a recombinant multi-epitope vaccine targeting sperm proteins IZUMO1, SACA3, and PH-20 effectively reduces fertility in female mice by inducing significant antibody responses that impair fertilization, all while maintaining a safe short-term histopathological profile.

Rozhia Zangeneh, Mojtaba Dashtizad, Seyed Ali Ghorashi, Ghazaleh Zandi, Farid heidari2026-07-08
🧬 biology

Rural Living Experience as a Determinant of Rapid Naming Performance in Chinese Adults

This study demonstrates that a higher proportion of lifetime rural living experience is independently associated with reduced rapid naming performance and slower processing speed in cognitively normal Chinese older adults, highlighting a significant, underrecognized source of environmental bias in language-based cognitive assessments.

Tianyu Gao, Wei Wu, Yapeng Liu, Zhe Wang, Anna Yao, Chen Chen, Yuexin Ma, Yifei Gao, Yuwen Cheng, Yu Chen, Eun Sung Jee (…)2026-07-08
🧬 biology

OsWD40-193 negatively regulated resistance to Hirschmanniella mucronata in Oryza sativa

This study elucidates that the transcription factor OsDERF1 enhances rice resistance to the nematode *Hirschmanniella mucronata* by repressing the expression of the negative regulator OsWD40-193, which interacts with ABF95813 to suppress resistance via the jasmonic acid signaling pathway.

Rong Zeng, Aocheng Ai, Yankun Liu, Jingling Li, Yujie Li, Yachun Lin, Weigang Kuang, Xiaotang Sun, Lianhu Zhang, Ruqiang (…)2026-07-08
🧬 biology

Parameter-Efficient Adaptation of a Vision Foundation Model Maps the Allometric Scaling Laws of Gastric Tumor Ecology

This study demonstrates that a parameter-efficient adaptation of the MUSK vision foundation model using Low-Rank Adaptation not only achieves high diagnostic accuracy for gastric cancer in a resource-constrained Chilean cohort but also enables a novel allometric ecological framework that quantifies tumor morphotype heterogeneity while mathematically correcting for sampling biases to improve patient stratification.

David Muñoz-Maulen, Jorge Maturana, Adolay Sobarzo, Melissa Ormeño, Francisco Tapia-Belmonte, Alexis Salas-Burgos2026-07-08
🧬 biology

Molecular and Functional Dysregulations in Novel, Rett Syndrome Patient-Derived Cerebral Organoids

This study establishes a scalable, patient-derived clonal cerebral organoid model harboring the R270X mutation that recapitulates key molecular and functional deficits of Rett syndrome, thereby providing a robust platform for mechanistic insights and therapeutic evaluation.

Klaudia M. Braczyk, Iliya Y. Voytsyshyn, Viktoria Haghani, Timothy Fenton, Mandeep Singh, Camille Loret, Peter Beal, Roy (…)2026-07-08
🧬 biology

From Splits to Heat Strain: A Ten-Year Analysis of Performance Determinants and a Digital Twin Prototype for Olympic-Distance Triathlon Developed Using a Generative AI Workflow

This ten-year analysis of over 7,000 Olympic-distance triathlon records utilizes a human-in-the-loop generative AI workflow to identify the run leg as the primary performance discriminator, assess heat resilience, and develop a digital twin prototype for optimizing race planning and heat-strain management.

Marco Cardinale2026-07-08
🧬 biology

Escherichia coli–based Nanobody Production: High-Cell-Density Process Development and Benchmarking of Strain-Plasmid Combinations

This study establishes a robust high-cell-density fed-batch process in *E. coli* that, through the optimization of induction timing, temperature, and host-strain combinations, achieves yields exceeding 2.5 g/L of functional anti-CD45 nanobodies, with periplasmic secretion proving superior to cytoplasmic production in terms of yield, thermal stability, and folding uniformity.

Jan-Angelus Meyer, Marie Beneke, Sadija Altmüller, Alexander Reeb, Jannis Künzl, Nathalie Opilo, Theo Weise, Christos Go (…)2026-07-08
🧬 biology

Disease Associated Loss of an MHC Locus in the Tasmanian Devil: Evolutionary Consequences for Devil Facial Tumour Disease Resistance

This study provides the first empirical evidence that the emergence of devil facial tumour disease has driven the adaptive loss of a specific MHC-I locus and a reduction in MHC diversity in Tasmanian devils, reshaping their immune gene architecture to enhance tumour resistance while potentially compromising future resilience to other pathogens.

Carolyn Hogg, Kimberley Batley, Ruth Pye, Luke Silver, Katherine Farquharson, Yuanyuan Cheng, Andy Flies, Katherine Belo (…)2026-07-08