4413 papers
This study identifies *Bacillus subtilis* strain WW12, isolated from wild wolf feces, as a safe and effective probiotic candidate that alleviates murine colitis by enhancing stress tolerance, inhibiting pathogens, modulating gut microbiota, and suppressing inflammatory signaling pathways.
This experimental animal study demonstrates that electrical impedance tomography (EIT) effectively enables continuous, dynamic monitoring of hydrocephalus progression in rabbits, showing a strong negative correlation with intracranial pressure in acute cases and detecting spatial changes in both acute and chronic models, though with greater sensitivity to acute progression.
This study demonstrates that atrial-specific overexpression of TGF-β1 in transgenic goats significantly increases atrial fibrillation susceptibility and extracellular matrix protein expression without altering inflammatory cell levels, thereby confirming fibrosis as a key driver of arrhythmia independent of inflammation.
This study reveals that in zebrafish larvae, distinct subpopulations of muscle precursor cells defined by differential expression of the paralogs *pax7a* and *pax7b* exhibit unique proliferative and fusion behaviors, with *pax7a*-expressing cells driving new fiber formation and growth while *pax7b*-only cells contribute minimally to larval myogenesis.
This paper proposes and validates a practical pre-hardware assessment method that combines average quantum relative entropy and backend-specific transpilation depth to predict and explain the noise robustness of quantum binary classifiers, addressing the limitations of using ideal accuracy or circuit depth alone.
This study establishes safe, behaviorally neutral dosing ranges for Edible Bird's Nest (60–90 mg/kg) and Thymoquinone (20–110 mg/kg) in zebrafish by demonstrating that high doses cause toxicity while lower doses enhance locomotor activity without inducing anxiety, thereby optimizing parameters for future neuroprotective research in Parkinson's disease.
This study demonstrates that intermittent theta-burst stimulation (iTBS) mitigates subacute ischemic stroke injury by suppressing neuronal pyroptosis in the peri-infarct region through a microglia-dependent mechanism involving the downregulation of Kv1.3 channels to shift microglia from a pro-inflammatory to an anti-inflammatory phenotype.
This study employs an integrative computational and experimental approach to identify resveratrol as a promising anti-virulence agent that effectively targets the LuxS system, thereby inhibiting quorum sensing and biofilm formation in multidrug-resistant *Klebsiella pneumoniae*.
This study presents the most comprehensive catalog of endogenous viral elements (EVEs) to date by analyzing 19 Culicinae mosquito genomes, revealing extensive viral diversity, non-random integration patterns, and the conservation of dominant EVEs that offer new insights into mosquito evolution and antiviral immunity.
This study demonstrates that in *Anopheles gambiae* populations from Cameroon, metabolic resistance (E205D-CYP6P3) and target-site resistance (L995F-kdr) impose distinct, stage-specific fitness costs that lead to the rapid decline of target-site mutations but the persistence of metabolic resistance under relaxed insecticide pressure, highlighting the need for mechanism-tailored resistance management strategies.