🧬 biology

Semi-automated sex estimation from cochlear shape using clinical CT imaging and OTOPLAN segmentation

This study demonstrates that a semi-automated pipeline using clinical CT scans and OTOPLAN segmentation can achieve moderate accuracy (79%) in sex estimation by analyzing cochlear shape descriptors, offering a non-destructive and scalable alternative for forensic anthropology when traditional skeletal methods are unavailable.

Priya VISHNUMURTHY, Mary DAVAL, Luke HELPARD, Ismael OUZZINE, Ralph HADDAD, Nikola IVANOVIC, Vincent JOURDES, Justin MIC (…)2026-07-07
🧬 biology

Impact of a phantomless calibration method on two finite element models predicting metastasised femoral strength

This study demonstrates that a phantomless air-fat-muscle calibration method is a reproducible and promising alternative to phantom-based calibration for predicting metastasised femoral strength using both linear and non-linear finite element models, with the linear Lyon model showing greater robustness to calibration differences.

Aurélie Levillain, Marc Gardegaront, Marine Grandin, Thibault Gandet, Elise Jourdain, Mélanie Roche, Guillaume Larid, Je (…)2026-07-07
🧬 biology

Protective Effects of Graded Doses of Aqueous Seed Extract of Dennettia tripetala on Ovarian Biochemical, Hormonal, and Microbiological Alterations in Bisphenol A-Induced Oxidative Stress in Female Wistar Rats

This study demonstrates that the aqueous seed extract of *Dennettia tripetala* significantly protects female Wistar rats from Bisphenol A-induced ovarian oxidative stress, hormonal disruption, and microbial burden in a dose-dependent manner, with the 800 mg/kg dose showing efficacy comparable to Vitamin C.

Gogo James Owo, Achinike Austin Okwelle, Kingsley Chimene Enyindah2026-07-07
🧬 biology

Genomic variations driving the transmission of multidrug-resistant Mycobacterium tuberculosis Lineage 2

This study analyzes genomic data from over 11,000 *Mycobacterium tuberculosis* Lineage 2 isolates to reveal that their global transmission and multidrug resistance are driven not by single high-effect mutations, but by the combined influence of multiple moderate-effect variants affecting drug resistance, cell-envelope functions, lipid metabolism, and parallel evolution.

Jinjiang Hu, Yao Liu2026-07-07
🧬 biology

Experimental and analysis parameters affect the quality of deconvolution of overlapping event-related potentials

This study demonstrates that the accuracy of deconvolving overlapping event-related potentials using general linear modeling is critically dependent on the complex interactions between experimental design factors (temporal jitter and sequential correlation) and analytical parameters (modeling window length and regularization), which can be unified and predicted through multicollinearity analysis to guide optimal experimental planning.

Noa Guttman, Leon Y. Deouell2026-07-07
🧬 biology

A tonoplast cytokinin riboside transporter gates intracellular hormone availability at the root–microbe interface

This study identifies the tonoplast-localized transporter ENT1 in *Arabidopsis thaliana* as a critical gatekeeper of intracellular cytokinin riboside availability that regulates hormone homeostasis and is essential for enabling beneficial microbe-induced plant defense against pathogens.

Ondřej Plíhal, Martin Hudeček, Daniel Nedvěd, Anna Kuchařová, Sándor Forczek, Marharyta Kuzmenko, Petr Klima, Vladimír S (…)2026-07-07
🧬 biology

LncRNA BCYRN1 regulates mitochondrial MT-ND1/4/5 transcription via heavy strand promoter methylation to promote oxidative phosphorylation and proliferation in acute myeloid leukemia

This study reveals that the mitochondria-localized lncRNA BCYRN1 promotes acute myeloid leukemia progression by epigenetically activating the transcription of MT-ND1/4/5 via heavy strand promoter methylation to enhance oxidative phosphorylation, identifying both the lncRNA and the mitochondrial RNA polymerase inhibitor IMT1B as promising therapeutic targets.

Ye Kuang, Jia Wang, Jing Li, Chuanmei Peng, Yong Ji, Jinrong Tian, Sulian Chen, Shiyan Nian, Lei Feng2026-07-07
🧬 biology

Single-cell and spatial transcriptomic profiling of primary versus recurrent glioblastoma identifies PLOD2 as a core orchestrator of hypoxic niche remodeling and mesenchymal transition

This study integrates multi-omics profiling to identify PLOD2 as a critical driver of glioblastoma recurrence that orchestrates hypoxic niche remodeling and mesenchymal transition via a PLOD2/LAMA4 axis, thereby promoting treatment resistance and offering a potential therapeutic target.

Zhong Wang, Fei Wang, Wenqian Cao, yuhan Bai, Yining Zhang, Chen Yang, Run Huang, Haohao Qiu, Yanbo Yang, Juyi Zhang, Yo (…)2026-07-07