4413 papers
This study identifies the METTL3-IGF2BP3 m⁶A axis as a critical driver of mutant huntingtin accumulation and neurodegeneration in Huntington's disease, demonstrating that targeting this epitranscriptomic pathway selectively reduces mHTT toxicity and inflammation in affected cells.
This study demonstrates that miR-217 acts as a tumor suppressor in pancreatic cancer by directly targeting and downregulating ENO1, which subsequently inhibits the AKT1 signaling pathway and epithelial–mesenchymal transition to suppress cell proliferation and promote apoptosis.
This study identifies a conserved epigenetic-transcriptional axis in schizophrenia characterized by PTPRN hypermethylation-driven repression, which links early neurodevelopmental perturbations in adolescent-derived cells to persistent molecular alterations in the adult brain.
This study identifies a late-phase glycemic response phenotype (∆G) during fasted moderate-intensity running as a reliable metric only when averaged across repeated trials, revealing that while it correlates with skeletal muscle index in recreational exercisers, this association is confounded by sex and exercise intensity, indicating ∆G is not a direct biomarker of muscle mass.
This study identifies and validates APOD, IGFBP3, and LPL as key therapeutic targets of the Xiaozhengtongluo formula in treating diabetic nephropathy by integrating Mendelian randomization, network analysis, and experimental verification to elucidate their causal roles and underlying molecular mechanisms.
This paper updates the comprehensive inventory of nonindigenous amphibians and reptiles in Florida through 2025, revealing that 64 nonnative taxa are now established—driven historically by Cuban cargo shipments and currently by the pet trade—while also documenting new interceptions, unestablished introductions, and taxonomic revisions.
This study integrates multi-omics and single-cell data to define a reproducible, redox-remodeled ferroptosis-resistant epithelial state in endometrial cancer that transcends molecular subtypes and identifies a ranked set of candidate genes driving this resistance phenotype.
This study demonstrates that ORP5 protects against myocardial infarction-induced cardiac injury by translocating to mitochondria-associated membranes to directly interact with and inhibit VDAC1 oligomerization, thereby preserving mitochondrial function and suppressing cardiomyocyte apoptosis.
This study demonstrates that 4-Methylumbelliferone (4MU) exerts antitumor effects in glioblastoma cells by inducing early oxidative stress that depletes NAD⁺, disrupts N-glycosylation, and triggers compensatory metabolic rewiring, thereby revealing a novel mechanism for targeting metabolic vulnerabilities in this aggressive brain tumor.
This study demonstrates that two massive coral species in a remote southwestern Gulf of Mexico reef system exhibited sustained molecular stress responses, indicated by progressively elevated HSP70 expression, during the extreme 2023–2025 marine heatwaves, revealing species-specific physiological strategies and the approach of thermotolerant corals to their functional limits under recurring thermal stress.