🧬 Category

q-bio

4477 papers

🧬 biology

Escherichia coli–based Nanobody Production: High-Cell-Density Process Development and Benchmarking of Strain-Plasmid Combinations

This study establishes a robust high-cell-density fed-batch process in *E. coli* that, through the optimization of induction timing, temperature, and host-strain combinations, achieves yields exceeding 2.5 g/L of functional anti-CD45 nanobodies, with periplasmic secretion proving superior to cytoplasmic production in terms of yield, thermal stability, and folding uniformity.

Jan-Angelus Meyer, Marie Beneke, Sadija Altmüller, Alexander Reeb, Jannis Künzl, Nathalie Opilo, Theo Weise, Christos Go (…)2026-07-08
🧬 biology

Disease Associated Loss of an MHC Locus in the Tasmanian Devil: Evolutionary Consequences for Devil Facial Tumour Disease Resistance

This study provides the first empirical evidence that the emergence of devil facial tumour disease has driven the adaptive loss of a specific MHC-I locus and a reduction in MHC diversity in Tasmanian devils, reshaping their immune gene architecture to enhance tumour resistance while potentially compromising future resilience to other pathogens.

Carolyn Hogg, Kimberley Batley, Ruth Pye, Luke Silver, Katherine Farquharson, Yuanyuan Cheng, Andy Flies, Katherine Belo (…)2026-07-08
🧬 biology

Isolation, Characterization, and Probiotic Potential of Bacillus subtilis Strain WW12 from Wild Wolf (Canis lupus) Feces with Protective Effects Against Murine Colitis

This study identifies *Bacillus subtilis* strain WW12, isolated from wild wolf feces, as a safe and effective probiotic candidate that alleviates murine colitis by enhancing stress tolerance, inhibiting pathogens, modulating gut microbiota, and suppressing inflammatory signaling pathways.

Songda Li, Shiyi Yang, Hengchuan Zhang, Chuyuan Xu, An Hu, Jie Liu, Guilian Yang, Ming Li2026-07-08
🧬 biology

Impedance changes detected by electrical impedance tomography during acute and chronic hydrocephalus progression: An experimental animal study

This experimental animal study demonstrates that electrical impedance tomography (EIT) effectively enables continuous, dynamic monitoring of hydrocephalus progression in rabbits, showing a strong negative correlation with intracranial pressure in acute cases and detecting spatial changes in both acute and chronic models, though with greater sensitivity to acute progression.

Haoting Li, Mengmeng Wang, Bin Yang, Xuechao Liu, Wentao Li, Feng Fu, Jincheng Liu2026-07-08
🧬 biology

Electrophysiological and molecular characterization of a TGF-β1 goat model

This study demonstrates that atrial-specific overexpression of TGF-β1 in transgenic goats significantly increases atrial fibrillation susceptibility and extracellular matrix protein expression without altering inflammatory cell levels, thereby confirming fibrosis as a key driver of arrhythmia independent of inflammation.

Misha Regouski, Jens Fillmore, Raquel Larsen, Cheyenne Marriott, Tayler Patrick, Alexis Sweat, Rusty Stott, Aaron Thomas (…)2026-07-08
🧬 biology

Pax7a expressing muscle precursor cells preferentially generate new fibres during larval muscle growth

This study reveals that in zebrafish larvae, distinct subpopulations of muscle precursor cells defined by differential expression of the paralogs *pax7a* and *pax7b* exhibit unique proliferative and fusion behaviors, with *pax7a*-expressing cells driving new fiber formation and growth while *pax7b*-only cells contribute minimally to larval myogenesis.

Tapan G. Pipalia, James E. N. Minchin, Simon M. Hughes2026-07-08
🧬 biology

Average Quantum Relative Entropy and Transpilation Depth as Indicators of Noise Robustness in Quantum Binary Classification

This paper proposes and validates a practical pre-hardware assessment method that combines average quantum relative entropy and backend-specific transpilation depth to predict and explain the noise robustness of quantum binary classifiers, addressing the limitations of using ideal accuracy or circuit depth alone.

Aakash Ravindra Shinde, Arianne Meijer - van de Griend, Jukka K. Nurminen2026-07-08
🧬 biology

Neuroprotective Potential of Edible Bird’s Nest and Thymoquinone in Parkinsonian Zebrafish

This study establishes safe, behaviorally neutral dosing ranges for Edible Bird's Nest (60–90 mg/kg) and Thymoquinone (20–110 mg/kg) in zebrafish by demonstrating that high doses cause toxicity while lower doses enhance locomotor activity without inducing anxiety, thereby optimizing parameters for future neuroprotective research in Parkinson's disease.

Khaled Ramadan Algantri, Zunariah Bt. Buyong, Muhammad 'Adil Bin Zainal Abidin, Abdul Rahman Mahmoud Fata Nahas, Mohd Ha (…)2026-07-08
🧬 biology

Targeting Kv1.3 Potassium Channels: iTBS Attenuates Pro-Inflammatory Microglia to Mitigate Early Neuroinflammation and Neuronal Pyroptosis After Ischemic Stroke

This study demonstrates that intermittent theta-burst stimulation (iTBS) mitigates subacute ischemic stroke injury by suppressing neuronal pyroptosis in the peri-infarct region through a microglia-dependent mechanism involving the downregulation of Kv1.3 channels to shift microglia from a pro-inflammatory to an anti-inflammatory phenotype.

Meixi Liu, Yi Lin, Congqin Li, Zijian Hua, Guohui Yang, Chong Guan, Congyu Jiang, Junfa Wu, Yi Wu, Xiao Xiao, Lu Luo2026-07-08