4477 papers
This study employs an integrative computational and experimental approach to identify resveratrol as a promising anti-virulence agent that effectively targets the LuxS system, thereby inhibiting quorum sensing and biofilm formation in multidrug-resistant *Klebsiella pneumoniae*.
This study presents the most comprehensive catalog of endogenous viral elements (EVEs) to date by analyzing 19 Culicinae mosquito genomes, revealing extensive viral diversity, non-random integration patterns, and the conservation of dominant EVEs that offer new insights into mosquito evolution and antiviral immunity.
This study demonstrates that in *Anopheles gambiae* populations from Cameroon, metabolic resistance (E205D-CYP6P3) and target-site resistance (L995F-kdr) impose distinct, stage-specific fitness costs that lead to the rapid decline of target-site mutations but the persistence of metabolic resistance under relaxed insecticide pressure, highlighting the need for mechanism-tailored resistance management strategies.
This study demonstrates that inhibiting DNA demethylation with Bobcat339 attenuates experimental necrotizing enterocolitis in neonatal mice by suppressing TLR4-mediated inflammation, suggesting a promising therapeutic strategy for this condition.
Based on citizen science data from 2016 to 2025, this study reveals that urban conflicts between humans and jaguars or pumas in Brazil are relatively rare but concentrated in the Southeast and Central-West regions, with pumas being the primary species involved, highlighting the urgent need for targeted management strategies to mitigate human-wildlife overlap.
This study demonstrates that sustained low-intensity direct current electric fields induce a voltage-dependent, biphasic apoptotic response in HeLa cells via controlled membrane permeabilization, characterized by a hormetic viability recovery at intermediate doses and a shift from early to late apoptosis at higher intensities, while largely suppressing necrosis.
This study demonstrates that low-intensity direct current induces colloid-osmotic swelling in HeLa cells, which acts as an upstream physical trigger distorting mitochondrial function to initiate regulated electro-apoptosis rather than necrosis, offering a new biophysical framework for optimizing bioelectric cancer therapies.
This study utilized Response Surface Methodology with a Box-Behnken design to optimize a complex lyoprotectant formulation of skim milk, sucrose, and glycerol, successfully achieving a high viability rate of 85.73% for lyophilized *Penicillium chrysogenum* ACCC 30395 conidia, which closely matched the model's predicted value.
This study utilized comparative in vivo transcriptome analysis of *Beauveria bassiana* strain GHA at distinct infection stages to identify upregulated virulence genes involved in cuticle penetration and hemocoel colonization during its infection of the beneficial predator *Nesidiocoris tenuis*, offering a strategy to address the fungus's unintended toxicity to this biological control agent.
This bioinformatics study reveals that RAD51C is significantly overexpressed in cervical cancer and linked to DNA repair and cell-cycle pathways, yet it does not serve as a significant prognostic marker or correlate with major immune checkpoint genes despite showing specific associations with certain immune cell infiltrates.