4477 papers
NatCodon is a generative model that leverages protein structural information to optimize codon sequences for co-translational folding, significantly outperforming existing frequency-based methods by strategically deploying rare codons to enhance soluble protein yields and enable the expression of previously intractable targets.
This paper presents a unified deep learning system that utilizes ConvNeXt-V1 to automatically classify animal species and detect foot injuries from static track images, achieving high accuracy in a 12-class setting and demonstrating that injury detection is particularly effective when decoupled from species discrimination.
This study demonstrates that maternal high-fat diet-induced excess adiposity programs latent, sex-specific vulnerabilities in the immune, intestinal, and metabolic systems of offspring, which are unmasked as multisystem dysfunction following a postnatal *Streptococcus pneumoniae* infection.
This study reveals that the catalytic bias of the thermostable [FeFe]-hydrogenase Tk HydA2 is governed by a distributed regulation model where distinct perturbations in the first- and second-coordination spheres of its iron-sulfur clusters synergistically modulate kinetic, electrostatic, and redox-relay effects to fine-tune the enzyme's reversible H2 interconversion.
This study identifies the METTL3-IGF2BP3 m⁶A axis as a critical driver of mutant huntingtin accumulation and neurodegeneration in Huntington's disease, demonstrating that targeting this epitranscriptomic pathway selectively reduces mHTT toxicity and inflammation in affected cells.
This study demonstrates that miR-217 acts as a tumor suppressor in pancreatic cancer by directly targeting and downregulating ENO1, which subsequently inhibits the AKT1 signaling pathway and epithelial–mesenchymal transition to suppress cell proliferation and promote apoptosis.
This study identifies a conserved epigenetic-transcriptional axis in schizophrenia characterized by PTPRN hypermethylation-driven repression, which links early neurodevelopmental perturbations in adolescent-derived cells to persistent molecular alterations in the adult brain.
This study identifies a late-phase glycemic response phenotype (∆G) during fasted moderate-intensity running as a reliable metric only when averaged across repeated trials, revealing that while it correlates with skeletal muscle index in recreational exercisers, this association is confounded by sex and exercise intensity, indicating ∆G is not a direct biomarker of muscle mass.
This study identifies and validates APOD, IGFBP3, and LPL as key therapeutic targets of the Xiaozhengtongluo formula in treating diabetic nephropathy by integrating Mendelian randomization, network analysis, and experimental verification to elucidate their causal roles and underlying molecular mechanisms.
This paper updates the comprehensive inventory of nonindigenous amphibians and reptiles in Florida through 2025, revealing that 64 nonnative taxa are now established—driven historically by Cuban cargo shipments and currently by the pet trade—while also documenting new interceptions, unestablished introductions, and taxonomic revisions.