4477 papers
This study identifies the tonoplast-localized transporter ENT1 in *Arabidopsis thaliana* as a critical gatekeeper of intracellular cytokinin riboside availability that regulates hormone homeostasis and is essential for enabling beneficial microbe-induced plant defense against pathogens.
The study reveals that the GluN1-Met641Ile NMDA receptor variant reduces calcium permeability by inducing a largely calcium-impermeable subconductance state through enhanced interactions between the Ile641 side chain and the M2 pore loop.
This study reveals that the mitochondria-localized lncRNA BCYRN1 promotes acute myeloid leukemia progression by epigenetically activating the transcription of MT-ND1/4/5 via heavy strand promoter methylation to enhance oxidative phosphorylation, identifying both the lncRNA and the mitochondrial RNA polymerase inhibitor IMT1B as promising therapeutic targets.
This study integrates multi-omics profiling to identify PLOD2 as a critical driver of glioblastoma recurrence that orchestrates hypoxic niche remodeling and mesenchymal transition via a PLOD2/LAMA4 axis, thereby promoting treatment resistance and offering a potential therapeutic target.
This study utilizes whole-genome sequencing to demonstrate that while *Plasmodium vivax* infections in travelers within the Peruvian Amazon exhibit higher genetic diversity and heterogeneity, they largely remain genetically connected to local non-traveler populations, thereby supporting the integration of genomic and epidemiological data to distinguish imported from locally acquired malaria transmission.
This study presents a chromosome-level genome assembly of the copper-hyperaccumulating plant *Elsholtzia splendens*, revealing how transposon bursts, gene family expansions, and specific Heavy Metal ATPase networks collectively drive its extreme copper tolerance and offering valuable genetic targets for soil phytoremediation.
Coarse-grained molecular dynamics simulations reveal that the aurein 1.2 analogue LLAA exhibits stronger membrane insertion and deeper interaction with bacterial membranes compared to the native peptide, yet forms less stable pores that disassemble rapidly, whereas aurein 1.2 maintains long-lived pore stability, highlighting how subtle sequence and charge differences dictate membrane interaction mechanisms and pore dynamics.
This study utilizes untargeted GC-MS metabolomic profiling to demonstrate that while mouse retinal organoids preserve a conserved core metabolic signature of the native retina, they exhibit specific alterations in glycolytic, amino acid, and TCA cycle pathways that suggest incomplete metabolic maturation.
This study reports the isolation and complete genome characterization of the novel *Jerseyvirus* phage vB_SenS_Horemheb from Egyptian wastewater, confirming its potential as a safe therapeutic agent against foodborne salmonellosis due to the absence of virulence and resistance genes.
This study characterizes the heavy metal tolerance and siderophore-producing capabilities of two mold fungi isolated from a 16th-century Russian icon to identify specific tempera pigment areas vulnerable to degradation, thereby guiding targeted biocide treatments for the artwork's preservation.