4477 papers
This study utilizes integrated single-cell and spatial transcriptomics to reveal that residual oesophageal adenocarcinoma cells surviving neoadjuvant chemotherapy are supported by a specific fibroblast–myeloid niche, highlighting that treatment resistance arises from both malignant cell plasticity and microenvironmental protection.
This study formally describes and names *Babesia capensis* sp. nov., a novel large-form piroplasm causing disease in domestic cats in South Africa, based on its distinct morphological, genetic, and phylogenetic characteristics, while also noting its association with caracals and its responsiveness to diminazene aceturate treatment.
This study demonstrates that while mild perceived fatigue during repeated sit-to-stand movements preserves the spatial structure of muscle synergies, it induces selective timing adjustments in specific synergies that are closely linked to compensatory changes in center of mass control.
This study demonstrates that under hypoxic conditions, Golgi protein 73 (GP73) drives hepatocellular carcinoma progression by promoting the Warburg effect and epithelial-mesenchymal transition through the stabilization of HIF-1α, identifying the GP73–HIF-1α axis as a critical mediator of TACE resistance and a potential therapeutic target.
This study utilizes BAC-based physical mapping and targeted sequencing to resolve the fragmented architecture of the giant panda immunoglobulin light chain loci, providing a complete germline genomic characterization of 22 κ and 187 λ variable genes that establishes a critical foundation for immune repertoire analysis and species conservation.
This study reveals that orangutan alarm calls are assembled by a hidden generative rule producing complex, long-range dependent structures from eight call types, suggesting that key precursors to human vocal generativity existed in ancestral hominids.
This study reveals that the inactivation of the cervical cancer marker ZNF582 leads to the derepression of HERVH, which sequesters the NF-κB repressor NKRF to unleash NF-κB signaling and drive tumor progression, thereby identifying a ZNF582–HERVH–NKRF–NF-κB axis as a potential therapeutic target for cervical cancer.
This study demonstrates that lead acetate negatively impacts the adaptive responses of diverse organisms, including ciliates, fish, and rodents, across various levels of the trophic pyramid and phylogenetic development.
This study demonstrates that incorporating realistic dispersal behaviors, particularly cross-diffusion, into mutualistic meta-network models reveals that dispersal significantly destabilizes homogeneous steady states, thereby reversing previously reported positive relationships between stability and species richness while establishing a unimodal relationship with connectance.
This paper introduces GREAC, an open-source, alignment-free software tool that utilizes k-mer-based dimensionality reduction to extract discriminative genomic regions for accurate, explainable, and reference-independent classification of viral variants and evolutionary patterns.