q-bio papers | Gist.Science

Influence of Visual and Chemical Cues on nest and bower-building behaviours of Coptodon rendalli (Boulenger, 1905) and Ooreochromis shiranus (Boulenger, 1905) in Fibre tanks

This study demonstrates that both visual and chemical cues significantly influence the nest- and bower-building behaviors of *Coptodon rendalli* and *Oreochromis shiranus*, with optimal structure dimensions observed when males and females are separated by a fine net and when water contains specific levels of soil substrate-treated cues, providing valuable insights for improving hatchery breeding conditions.

Luckson Solicitor Maurice Gondwe2026-07-07

🧬 biology

Precursor-dependent steroid conversion sustains androgen receptor signaling and lineage-state divergence in prostate cancer

This study challenges the "tumor-as-gonad" dogma by demonstrating that castration-resistant prostate cancer relies on converting adrenal steroid precursors rather than autonomous de novo synthesis, revealing a metabolic and lineage plasticity spectrum that dictates androgen receptor signaling and survival risk.

Amit Pandey, Jibira Yakubu, Therina du Toit2026-07-07

🧬 biology

Apparent 3D-structural variant-effect signal is explained by variant category, not structure: a category-matched evaluation across nine disease loci

This study demonstrates that the apparent predictive power of a 3D chromatin structural-disruption score (ARCHCODE) for pathogenicity is largely an artifact of variant category rather than genuine structural information, as its performance collapses to chance levels when evaluated using category-matched controls, unlike established predictors such as CADD and phyloP.

Sergey Boiko2026-07-07

🧬 biology

Nest volume shapes termitophile abundance in Constrictotermes cyphergaster colonies

This study demonstrates that in *Constrictotermes cyphergaster* colonies, nest volume positively predicts the absolute abundance of termitophiles by increasing carrying capacity post-colonization rather than facilitating initial invasion, while the ratio of symbionts to host workers remains constant across all colony sizes.

Igor Eloi, Luisa Siqueira-Rocha, Maria Avany Bezerra-Gusmão2026-07-07

🧬 biology

PDIA6 promotes glioma malignancy by activating the IRE1α- p-HSP27 signaling axis

This study demonstrates that PDIA6 acts as an oncogene in glioma by activating the IRE1α-p-HSP27 signaling axis, thereby driving tumor progression and correlating with poor patient prognosis.

Wei Xiang, Tao Peng, Ming Wang, Zhengjun Zhou, Junjie Tian, Shenjie Li, Jie Zhou2026-07-07

🧬 biology

Genome sequence and annotation of Botrytis cinerea UCA992 strain

This paper presents the genome sequence, de novo assembly (GCA_053455415.1), and functional annotation of the metabolically unique *Botrytis cinerea* UCA992 strain, providing a publicly available resource to advance comparative genomics and metabolic research.

Víctor Coca-Ruiz, Ivonne Suarez, Nuria Cabrera-Gómez, Andrea L. Herrera, Vlad Paul Mihaila Novac, Nélida Brito, Jesus Ca (…)2026-07-07

🧬 biology

Multi-omics integration provides insights into the symbiotic evolution of the mycoheterotrophic medicinal orchid Gastrodia elata

This study presents a chromosome-level genome assembly and pan-gene analysis of the mycoheterotrophic orchid *Gastrodia elata*, revealing extensive degeneration of photosynthetic genes, the absence of fungal-derived horizontal gene transfer despite long-term symbiosis, and the identification of specific metabolic adaptations and the expanded GAFP gene family as key mechanisms for nutrient acquisition and symbiotic homeostasis.

Yiyong Zhao, Mingjin Huang, Shanshan Luo, Linshuang Tang, Hao Yin, Daliang Liu, Zhipeng Li, Qiyu Chen, Yinjie Jiao, Meng (…)2026-07-07

🧬 biology

Missense variants in KATNA1 alter microtubule dynamics and underlie dominant macular dystrophy

This study identifies heterozygous missense variants in KATNA1 as a novel cause of autosomal dominant macular dystrophy, demonstrating that these mutations impair katanin-mediated microtubule severing and lead to cytoskeletal dysregulation in photoreceptors.

Carlo Rivolta, Karolina Kaminska, Abigail Moye, Mathieu Quinodoz, Elena Zehr, Amel Aiteur, Giacomo Calzetti, Pilar Barbe (…)2026-07-07

🧬 biology

Dual-Mechanism Benefits of Mixed Reality in Motor Imagery BCIs: Simultaneous Signal Enhancement and Fatigue Mitigation

This study demonstrates that mixed reality significantly enhances motor imagery BCI performance by simultaneously improving EEG signal quality and classification accuracy while effectively mitigating cognitive fatigue during extended sessions through immersive engagement.

Hamza Bouallagui, Hamza Chniter, Fakhreddine Ghaffari, Olivier Romain2026-07-07

🧬 biology

Reliable but Wrong? Automated Detection of Heart Rate Artifacts as a Source of Bias in Pediatric EEG Data

This study demonstrates that the widely used ICLABEL algorithm, trained primarily on adult EEG, fails to detect cardiac artifacts in pediatric data, leading to significant biases in power estimates and spurious treatment effects, thereby highlighting the critical need for supervised validation when applying automated tools to pediatric populations.

Brenna Arledge, Tori Hollen, Akhila K. Nekkanti, Elizabeth A. Skowron, Lauren E. Ethridge, David E. Bard2026-07-07

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