🧬 Category

q-bio

3726 papers

🧬 biology

Biological characteristics and whole-genome sequencing analysis of an alpha-hemolytic Streptococcus pyogenes strain

This study characterizes an atypical alpha-hemolytic *Streptococcus pyogenes* strain (ST176/emm58.7) isolated from erysipelas, identifying a *sagB* gene mutation as the cause of its unusual hemolysis while confirming it retains significant virulence factors and macrolide/tetracycline resistance, thereby highlighting the risk of clinical underdetection for such phenotypically deviant pathogens.

Yufeng Mo, Qiaoyi Wang, Minli Qiu2026-09-10
🧬 biology

IMU-Based Hip Adduction and Flexion Moment Estimation for Osteoarthritis and Healthy Individuals During Normal and Modified Gait

This study presents a novel, personalized deep learning framework that accurately estimates continuous hip adduction and flexion moments from wearable IMU data across diverse gait patterns and populations, enabling low-burden, real-world monitoring of hip joint loading for osteoarthritis management.

Chenquan Xu, Zhongtian Yu, Yuanshuo Tan, Kezhe Zhu, Hong Wang, Qiqi Lu, Yueyuan Chen, Ziheng Xu, Guoxing Liu, Hai Hu, Pe (…)2026-09-10
🧬 biology

Detoxification Enzyme Modulation and Larvicidal Efficacies of Klebsiella pneumoniae (PX652414) and Proteus mirabilis (PZ337687) Metabolites in Mosquito Vectors

This study demonstrates that secondary metabolites from *Klebsiella pneumoniae* (PX652414) exhibit significant larvicidal efficacy against major mosquito vectors by suppressing detoxification enzymes, whereas *Proteus mirabilis* (PZ337687) metabolites show minimal activity and induce enzyme elevation.

Chinenye Ukubuiwe, Moses Abalaka, Azubuike Ukubuiwe, Ifeanyi Ossamulu, Nasiru Adabara, Israel Olayemi2026-09-10
🧬 biology

Disruption of Mechanotransduction in Glioblastoma Multiforme Cancer Stem Cells: A Computer Vision Protocol for the Identification of Molecular Vulnerabilities under Simulated Microgravity.

This paper proposes an innovative protocol that combines simulated microgravity, advanced computer vision, and protein folding algorithms to disrupt mechanotransduction in glioblastoma stem cells, thereby identifying cryptic molecular vulnerabilities for precision immunotherapy.

João Victor Rocha da Silva2026-09-10
🧬 biology

From Halotolerance to plant growth promotion: integrated genomic and physiological characterisation of the halotolerant plant growth-promoting bacterium Terribacillus halophilus EH3 from semi-arid vineyard soil

This study integrates genomic and physiological analyses to demonstrate that the novel halotolerant bacterium *Terribacillus halophilus* EH3, isolated from Australian vineyard soil, promotes plant growth and nutrient uptake under mild stress through a specialized genomic framework linking osmotic adaptation mechanisms with rhizosphere competence.

Erandi Herath, Danning Lui, Pangzhen Zhang2026-09-10
🧬 biology

Neurometabolic Plasticity in Denervated Adipose Tissue: Remodeling of Lipogenic Carbonic Anhydrase Isoenzymes

This study demonstrates that sympathetic denervation of white adipose tissue in rats triggers a transient, synchronized upregulation of lipogenic carbonic anhydrase isoenzymes (Car2, Car5A, and Car5B) at one month, followed by a partial normalization by three months, revealing a specific temporal pattern of neurometabolic plasticity that warrants further investigation into its functional metabolic consequences.

Hülya Kılıç, Mehtap Atak, Ahmet Alver2026-09-10
🧬 biology

Activation of hepatic USP5 as a novel strategy to ameliorate metabolic dysfunction-associated steatotic liver disease by deubiquitinating CPT-1A

This study identifies hepatic USP5 as a critical therapeutic target for metabolic dysfunction-associated steatotic liver disease (MASLD), demonstrating that USP5 stabilizes the fatty acid oxidation enzyme CPT-1A by removing K6-linked ubiquitin chains, and that the USP5 activator ligustroflavone effectively ameliorates MASLD symptoms by restoring this regulatory axis.

Feng Qin, Qinmei Sun, Jiamei Chen, Guanghao Zhu, Siting Gao, Yidan Shang, Yaoshan Zhou, Xin Xin, Kai Huang, Rutao Lin, F (…)2026-09-10
🧬 biology

Scalability of the Mechanobiological Vulnerability Index (MVI) in Triple- Negative Breast Cancer: A Microgravity-Induced Platform for In Silico Target Discovery

This paper proposes the Mechanobiological Vulnerability Index (MVI), a scalable computational platform that leverages simulated microgravity-induced cytoskeletal disorganization and deep learning models to identify novel therapeutic targets for Triple-Negative Breast Cancer by integrating physical and mechanical tumor properties with molecular profiling.

João Victor Rocha da Silva2026-09-10
🧬 biology

IL-17+ lymphocytes mark low-immunity, EMT-enriched tumors in primary triple-negative breast cancer: investigated in relation to tumor-infiltrating lymphocytes (CD8+, CD4+, FOXP3+) and macrophages (CD163+)

This study reveals that in primary triple-negative breast cancer, IL-17+ lymphocytes define a distinct low-immunity tumor phenotype enriched with epithelial–mesenchymal transition (EMT) features and metabolic reprogramming, contrasting with the favorable prognosis associated with other immune cell infiltrates like CD8+ and CD4+ T cells.

Gudbjörg Sigurjonsdottir, Tommaso De Marchi, Gyula Pekar, Felicia Leion, Anna Ehinger, Johan Hartman, Johanna Massalsky (…)2026-09-10