🧬 Category

q-bio

5841 papers

🧬 biology

Neural stem cells generate neurons in vitro which mimic their in vivo molecular identity and axon/dendrite morphology

This paper introduces a hanging drop culture protocol that enables the long-term growth of Drosophila neuroblast-derived neurons in vitro, demonstrating that these cultured neurons faithfully recapitulate their in vivo molecular identity, proliferation rates, and axon/dendrite morphology, thereby providing a robust model for studying the cues governing neuronal development.

Megan Radler, Chris Doe2026-10-27
🧬 biology

Coordinated adipose–liver metabolic remodelling reveals sex-specific peripheral adaptations during amyotrophic lateral sclerosis progression in TDP-43A315T mice

This study demonstrates that amyotrophic lateral sclerosis progression in TDP-43A315T mice involves extensive, coordinated metabolic remodelling in peripheral tissues like adipose and liver that exhibits distinct tissue-specific and sex-dependent patterns, suggesting peripheral metabolism contributes to disease heterogeneity and offers potential therapeutic targets.

Cristina Benito-Casado, Águeda Ferrer-Donato, Gemma Barroso-García, Germán Domínguez-Vías, Raúl Domínguez-Rubio, Mónica (…)2026-10-27
🧬 biology

Recoverable temporal and spectral information in public human macrophage imaging

This paper presents a reproducible audit of public human macrophage imaging data that identifies specific recoverable temporal and spectral information while highlighting significant limitations in pixel distinctness and intensity consistency, ultimately providing a resource-specific evidence matrix to guide the safe reuse of these datasets without claiming new tracking methods or population generalizations.

Elkin Navarro Quiroz2026-10-27
🧬 biology

Genetic and epigenetic correlates of co-occurring behavioral problems in early childhood

This study of the Norwegian Mother, Father and Child Cohort Study reveals that while genetic and epigenetic correlates of co-occurring internalizing and externalizing behavioral problems in early childhood are modest, they become more consistently detectable and biologically relevant as these behavioral phenotypes stabilize between ages three and five.

Yunpeng Wang, Mona Bekkhus, Stella Tsotsi, Rosa Mulder, Zoe Hart, Christian Page, Nikolai Olavi Czajkowski, Wanlin Liu (…)2026-10-27
🧬 biology

Rare coding variant burden and integrated genetic risk assessment in a Japanese schizophrenia cohort

This study presents a comprehensive whole-exome sequencing analysis of a Japanese schizophrenia cohort that confirms the enrichment of rare damaging variants in constrained and synaptic genes, identifies two new risk genes (ZMYM2 and SLC6A1) through cross-population meta-analysis, and demonstrates that ultra-rare coding variants, pathogenic copy number variants, and polygenic risk scores independently contribute to schizophrenia risk in an integrated genetic assessment.

Itaru Kushima, Sawako Furukawa, Yasue Horiuchi, Makoto Arai, Masanari Itokawa, Daisuke Mori, Yuko Arioka, Hiroki Okumura (…)2026-10-27
🧬 biology

Second-generation tau PET tracer in situ binding assessed with fluorescence imaging

This study validates the use of the non-radioactive fluorescent variant of the second-generation tau PET tracer [18F]GTP1 to confirm its specific binding to tau tangles and neuropil threads in post-mortem brain tissue, demonstrating a strong correlation with standard autoradiography results.

Aleksandra Antic, Ambra Dreos, Tammaryn Lashley, Stephen Yong Yo-Ap, Kerstin Sander, Michael Schöll, Jörg Hanrieder2026-10-27
🧬 biology

Facial Muscle Fiber Composition: Novel Morphological Muscle Cartography for Clinical and Neuromechanical Implications

This study presents the first comprehensive map of human facial muscle fiber composition by characterizing Myosin Heavy Chain isoforms across 21 facial muscles, revealing a predominance of Type IIA fibers and distinct clustering patterns that establish a foundation for biomechanical modeling, surgical reconstruction, and rehabilitation.

Johanna Klepetko, Laurenz Pflaum, Viktoria Rejzek, Vlad Tereshenko, Udo Maierhofer, Florian J. Jaklin, Leopold Harnoncou (…)2026-10-27
🧬 biology

Age-related differences in cortical functional connectivity during du al-task walking: a cross-sectional fNIRS study

This cross-sectional fNIRS study reveals that healthy older adults exhibit distinct cortical functional connectivity patterns during dual-task walking compared to younger adults, characterized by reduced connectivity in the right prefrontal and premotor/supplementary motor areas alongside increased prefrontal–supramarginal gyrus connectivity, which may reflect age-related alterations in cortical network organization.

Xin-Yang Zhang, Xiao-Ying Zhao, Jia-Jing Tian, Bao-Chuan Wang, Shi-Yao Wang, Bei-Yan Guan, Chun-Li Song, Lin Zhang, Bing (…)2026-10-27
🧬 biology

Individual Catch-Phase Paddle Configurations in Elite Para-Kayak Athletes: A Reference-Based Kinematic Single-Case Series

This exploratory study reveals that elite para-kayak athletes exhibit distinct individual paddle configurations at the catch phase that deviate from the established Olympic reference profile, suggesting that while the latter serves as a useful preliminary benchmark, optimal technique must account for specific functional constraints.

Maria Teresa Benincasa, Daniele Albano, Silvia Coppola, Claudia Costa, Francesco Coiro, Ester Celentano, Enrico Serra, R (…)2026-10-27