🧬 biology

Genome-wide characterization of the PLATZ transcription factor family in chickpea reveals evolutionary diversification and genotype-dependent responses to drought and salinity

This study comprehensively characterizes the chickpea PLATZ transcription factor family through genome-wide identification and multi-faceted analyses, revealing their evolutionary history, regulatory mechanisms, and distinct, genotype-dependent roles in mediating responses to drought and salinity stresses.

Anindita Barua, Dilip Sampatirao, Deepak Ranjan Kanth, Yaswanth Amara, Yashwant K. Yadava, Gopal Kalwan, Rakhi Tomar, Ka (…)2026-10-27
🧬 biology

Knee extension motor imagery paired with single-pulse TMS facilitates corticospinal excitability in the tibialis anterior muscle, but not in the rectus femoris muscle

This study demonstrates that while combining knee extension motor imagery with single-pulse TMS significantly enhances corticospinal excitability in the tibialis anterior muscle, it fails to produce similar facilitatory effects in the rectus femoris muscle, suggesting a muscle-specific limitation in plasticity for the latter.

Keiichi Ishikawa, Naotsugu Kaneko, Kimitaka Nakazawa2026-10-27
🧬 biology

Lower anther culture response in indica than in japonica rice is associated with a callus- induction bottleneck and early browning of sporophytic anther tissues

The lower anther culture response in indica rice compared to japonica is primarily caused by a bottleneck at the callus induction stage, which is driven by the rapid early browning of sporophytic anther tissues that prevents callus formation.

Christabell Nachilima, Nanami Kudo, Yuka Konno, Meilan Xu, Kosuke Miyamoto, Kana Takashima, Yoshiki Tokuyama, Yohei Koid (…)2026-10-27
🧬 biology

Epigenetic dysregulation of the protocadherin gamma cluster and cadherin signaling pathways in edematous severe acute malnutrition: an in-silico reanalysis of raw methylation data

This study utilized a robust bioinformatics pipeline to reanalyze raw methylation data from 374 samples, revealing that edematous severe acute malnutrition is characterized by a specific signature of hypomethylation in the protocadherin gamma cluster, which likely drives epithelial barrier dysfunction and tissue edema through disrupted cadherin signaling.

Kelvin Msoka2026-10-27
🧬 biology

Structural analysis of the 5' terminal of human immunodeficiency virus type 1 genome RNAs transcribed from proviruses with mutations in the transcription start site

This study demonstrates that HIV-1 RNAs transcribed from the second G residue of the transcription start site, when containing GC or GU at the 5' end, form stable structures similar to native genomic RNAs, suggesting they can function as genomic RNA despite mutations that typically prevent transcription from the third G residue.

Yuka Kashiyama, Gota Kawai, Takeshi Yoshida, Youichi Suzuki2026-10-27
🧬 biology

Heptyl prodigiosin from estuarine Zooshikella sp. RANM57 induces caspase-dependent apoptosis and suppresses clonogenic survival in androgen-independent prostate cancer cells

This study demonstrates that heptyl prodigiosin, a tripyrrole alkaloid isolated from the estuarine bacterium *Zooshikella* sp. RANM57, exhibits potent anticancer activity against androgen-independent prostate cancer cells by inducing dose-dependent, caspase-mediated intrinsic apoptosis and suppressing clonogenic survival.

Royston Stephen Madtha, Kedeke Balakrishna, Khansab Razak Deen, Selvam Rithick, Savarimuthu Ignacimuthu, Perumal Pandiku (…)2026-10-27