5841 papers
This study establishes a carbon-convergent strategy in engineered *Komagataella phaffii* that co-utilizes ethanol and CO2 to achieve a record-breaking 3-hydroxypropionic acid titer of 127.04 g/L, demonstrating the feasibility of coupling chemical CO2 reduction with microbial biosynthesis.
This study reveals that the mechanosensitive ion channel PIEZO2 in the endometrium safeguards fertility under maternal stress by converting myometrial contractions into enhanced progesterone receptor transcription via the FAK–Hippo/YAP–TEAD signaling pathway, a mechanism whose dysfunction contributes to recurrent implantation failure in humans.
Using CRISPR-Cas9 editing in a Senegalese *Plasmodium falciparum* isolate, this study demonstrates that the parasite's genetic background acts as a strict evolutionary filter that uncouples short-term artemisinin tolerance from long-term persistence, allowing emerging African *Pfkelch13* alleles to establish stable resistance without the competitive penalty observed for the Asian I543T mutation.
This study isolated and identified lactic acid bacteria from beet, oat, and monastic kvass, demonstrating that the resulting strains exhibit promising probiotic traits—including acid and bile tolerance, antagonistic activity against pathogens, and high autoaggregation—despite lacking specific enzymatic activities, thereby supporting their potential use in functional food production.
This study demonstrates that activating α7 nicotinic acetylcholine receptors with agonists like PNU-282987 or GTS-21 attenuates Brucella-induced inflammation in murine macrophages by suppressing the NLRP3 inflammasome and NF-κB signaling pathways while enhancing JAK2/STAT3 and ERK1/2 activation.
This study demonstrates that aquifer geochemistry is a primary driver of microbial community structure and metabolic potential, including carbon and nitrogen cycling, in groundwater ecosystems across Aotearoa New Zealand, as revealed by the analysis of 494 metagenome-assembled genomes from 39 samples.
This systematic review synthesizes findings from the Adolescent Brain Cognitive Development Study, revealing that neuroimaging correlates of adolescent substance use are distributed and context-dependent, but current observational limitations prevent the establishment of validated MRI screening tools or causal conclusions.
This study provides the first comprehensive molecular characterization of Tomato yellow leaf curl virus (TYLCV) in Ukraine, revealing that 52.9% of symptomatic tomato plants and adjacent pepper and zucchini crops were infected with genetically homogeneous isolates belonging to the TYLCV-Israel lineage, likely indicating a recent introduction of the virus.
This population genomics study utilizes machine learning on 1,720 Salmonella genomes to demonstrate that differential virulence among non-typhoidal serovars is strongly associated with the presence of specific genetic determinants, particularly Salmonella Pathogenicity Islands 13 and 14, which are enriched in virulent strains and absent in attenuated ones.
This study identifies and functionally characterizes PpAP1, a Cardosin B homolog in the moss *Physcomitrium patens*, demonstrating that its overexpression confers aspartic protease-dependent milk-clotting activity, thereby establishing it as a promising plant-based alternative for dairy biotechnology.