3726 papers
This controlled ablation study reveals that in GNN-based protein function prediction, the proposed Information Accretion-aware loss function is counterproductive, whereas the optimal performance is achieved by combining a GCN architecture with cross-ontology attention and standard binary cross-entropy loss.
This study reveals that the bat-derived influenza H18 haemagglutinin binds to MHC class II molecules at a novel site distinct from the canonical sialic-acid pocket, inducing conformational changes that prime viral fusion and demonstrating the protein's structural adaptability to utilize protein receptors for host entry.
This study evaluates porcine antisense oligonucleotide RNA-seq data to determine the viability of cross-species virtual-knockout benchmarking, concluding that while whole-transcriptome scoring is unreliable due to estimator discrepancies, leading-gene rank scoring is reproducible and offers a defensible target for extending human-derived perturbation models to livestock.
This cross-national study reveals that while urinary microbial richness is similar, the overall community composition and specific taxonomic abundances in patients with urolithiasis differ significantly between Taiwan and South Korea, suggesting that geographic and environmental factors shape distinct urinary microbiota profiles associated with stone disease.
This study introduces a scalable low-rank differentiable causal discovery method to reconstruct the first genome-wide directed regulatory network in human cancer, revealing a conserved cross-module architecture dominated by druggable date hubs that capture regulatory relationships largely independent of genetic essentiality.
This study adapts and evaluates the psychometric properties of the BANKS-SP biobanking survey in Colombian and Nicaraguan dengue cohorts, finding that while the Self-efficacy Scale performed adequately, the Attitudes Scale requires revision and both sites exhibited significant gaps in knowledge regarding biospecimen governance and legal frameworks.
This study demonstrates that umbilical cord mesenchymal stem cells (UC-MSCs) alleviate oxidative stress-induced osteoblast differentiation disorders and inhibit ferroptosis by upregulating miR-218-5p, which targets and suppresses CBX3, thereby restoring osteogenic function via the miR-218-5p/CBX3 signaling axis.
This study demonstrates that while a *Pseudomonas marincola* CheB-like hydrolase possesses a Ser–His–Asp motif, its noncanonical catalytic geometry and limited oligomer docking poses indicate it is not preorganized for efficient PET degradation, highlighting that motif conservation alone does not guarantee enzymatic function.
This paper introduces an open-source, training-free ImageJ/Fiji plugin that combines StarDist nuclear detection with a topology-guided Voronoi-based segmentation strategy and adaptive calibration to achieve highly accurate, reproducible automated quantification of nuclear and cytoplasmic H-scores across diverse immunohistochemistry datasets.
The study introduces Reduced Representation Nanopore Sequencing (RRNS), a cost-effective workflow that combines MspI-based targeted enrichment with direct nanopore sequencing to enable high-throughput, accurate DNA methylation profiling while overcoming the limitations of bisulfite conversion and high whole-genome sequencing costs.