🧬 Category

q-bio

1498 papers

🧬 biology

Spiro[indoline-tetrazolo[1,5-c]quinazoline] derivatives as candidate HDAC8 inhibitors: a molecular docking and ADMET analysis using the HDAC8–inhibitor complex (PDB 2V5X)

This study identifies novel spiro[indoline-tetrazolo[1,5-c]quinazoline] derivatives as promising non-hydroxamate HDAC8 inhibitors through molecular docking and ADMET analysis, demonstrating superior binding scores and favorable cytotoxicity profiles driven by specific pharmacophoric interactions that may offer improved selectivity and reduced toxicity compared to conventional inhibitors.

Lyudmyla Antypenko, Oleksii Antypenko, Yuliia Kozak, Volodymyr Salionov, Mykola Maletskyi, Hanna Lysianska, Serhii Koval (…)2026-07-22
🧬 biology

Pulmonary Capillary Confinement Shapes Bacteria-engaging Neutrophil Fate Transition

Quantitative lung intravital imaging reveals that mechanical confinement during pulmonary capillary transit triggers GsMTx4-sensitive calcium signaling and nuclear remodeling in neutrophils, leading to the formation of motile anuclear cytoplasts that preferentially engage *Pseudomonas aeruginosa*, thereby establishing the capillary bed as a mechanical checkpoint for early host–microbe interactions.

Yoshikazu Tsukasaki, Kaori Masuhara2026-07-22
🧬 biology

Learning Canonical Representations for Unified 3D Molecular Modeling

The paper introduces TheMol, a 3D molecular representation framework that learns a canonical frame to decouple global pose from representation learning, enabling a single unified model to effectively handle diverse tasks like property prediction, coordinate generation, and structure-based optimization while improving rotational stability and latent-space structure.

Sanghyun Park, Seungyeon Choi, Hwanhee Kim, yoonju kim, seungyong lee, inpyo hong2026-07-22
🧬 biology

Attenuation of typical sex differences in the time-resolved functional connectivity of the fusiform gyrus in autism

This study utilizes micro co-activation patterns analysis on resting-state fMRI data to reveal that autism is characterized by an attenuation and reversal of typical sex differences in the dynamic functional connectivity and spatial extent of fusiform gyrus subregions coupled with the default mode network, highlighting sex as a critical dimension of neurobiological heterogeneity in social cognition.

Dorothea Floris, Luigi Saccaro, Farnaz Delavari, Dawid Strzelczyk, Bruno Hebling Vieira, Camille Elleaume, Charlotte Pre (…)2026-07-22
🧬 biology

A genomic history of African cattle

By analyzing whole-genome sequences from nearly 5,000 African cattle, including ancient samples, this study reveals that the continent's cattle represent a complex mosaic of distinct taurine and indicine lineages whose geographic distributions and evolutionary trajectories have been uniquely shaped by contrasting human subsistence strategies, specifically the sedentary farming of taurine breeds versus the mobile pastoralism driving indicine dispersal.

Laurent Frantz, Said Ng'ang'a, James Ward, Gillian McHugo, Mica Jones, Olaf Thalmann, Mbunkah Achukwi, Adeniyi Adeola, T (…)2026-07-22
🧬 biology

Optimizing a Human Forensic STR Panel for Non-Invasive Genetic Monitoring of Chimpanzees (Pan troglodytes)

This study presents a standardized framework for adapting the human GlobalFiler™ forensic kit to chimpanzee genotyping, successfully optimizing a 16-locus panel from non-invasive samples in Cameroon that achieves high amplification success and discriminatory power for individual identification and conservation monitoring.

Shrutarshi Paul, Fabrice Kentatchime, Tyler Andres-Bray, Tista Ghosh, Giovana Naira Pereira Couto, Kevin Njabo, Mary Kat (…)2026-07-22
🧬 biology

AlphaFold-derived local structural confidence in BRCA1 missense variant interpretation: a ClinVar-based computational analysis

This study demonstrates that AlphaFold-derived local structural confidence (pLDDT) scores are strongly associated with the clinical classification of BRCA1 missense variants, suggesting that pLDDT serves as a valuable contextual tool for refining the interpretation of variants of uncertain significance alongside existing computational predictors.

Yaroslav Yasinskyi, Mariana Chopei, Andrei Sivolob2026-07-22
🧬 biology

Decoding Overlapping Lower-Limb Afferent Pathways from Human Epidural Spinal Recordings

This study demonstrates that clinical-grade lumbosacral epidural arrays can successfully decode distinct overlapping common fibular and tibial nerve afferent signals in humans with high accuracy, establishing a viable pathway for rapid, closed-loop neuromodulation without the need for invasive penetrating or peripheral interfaces.

Alexander Steele, Milton Candela, Gracie Hufft, Amanda Howes-Keith, Catherine Martin, Jeonghoon Oh, Amir Faraji, Dimitry (…)2026-07-22
🧬 biology

CRISPR/Cas9-mediated miR-155 knockout suppresses glioblastoma cell proliferation through TP53INP1/p53/p21 activation

This study demonstrates that stable CRISPR/Cas9-mediated knockout of miR-155 suppresses glioblastoma cell proliferation by activating the TP53INP1/p53/p21 signaling axis, while exerting only limited and heterogeneous effects on other malignancy-associated traits such as migration and invasion.

Jung Bae Seong, Se-Hee Choe, Wi-Jae Lee, Sang-Je Park, Junghyung Park, Hyoung-Chin Kim, Jae-Won Huh, Seung Hwan Lee, Yeo (…)2026-07-22