1498 papers
This study utilizes a haplotype-based framework to analyze three decades of wheat breeding data in the Northern Plains, revealing that Fusarium head blight resistance is highly polygenic and has improved through the directional selection of multiple small-effect resistance alleles without compromising local genetic diversity.
This study demonstrates that social stress in zebrafish induces anxiety-like behaviors and oxidative stress in subordinate individuals, which are reversed by the 5-HT1A receptor agonist 8-OH-DPAT, suggesting that the drug's efficacy is modulated by social hierarchy through receptor desensitization and sensitization.
This study characterizes SNAPC4-related neurodevelopmental disorder as a heterogeneous, stage-dependent spliceosomopathy caused by loss-of-function variants that destabilize the SNAPc complex and disrupt snRNA transcription, leading to a wide spectrum of clinical and neuroimaging abnormalities.
By integrating ancestral sequence reconstruction with structure-guided mutagenesis, researchers successfully engineered the *Aspergillus oryzae* reductive aminase to achieve significantly enhanced catalytic activity and thermostability in variants Anc74_7 and Anc75_20.
This study introduces MitoBrainMap, a novel, label-free MRI framework that successfully predicts individualized mitochondrial features in the living human brain, revealing age-related declines, disease-specific alterations in mitochondrial diseases, and meaningful links to systemic physiology and cognitive performance.
This study utilizes simultaneous corticospinal resting-state fMRI and functional connectivity gradients to integrate the human spinal cord into a unified low-dimensional manifold with the sensorimotor cortex, revealing an asymmetric hierarchical organization where spinal inputs broaden cortical axes while cortical inputs preserve spinal gradients, thereby extending gradient-based mapping beyond the cortex to describe the entire neuraxis as coupled manifolds.
By combining magnetoencephalography with electrodermal activity during a sustained-threat task, this study reveals that specific cortical oscillatory patterns precede sympathetic arousal and that the strength of this neural–autonomic coupling, rather than cortical power or arousal levels alone, serves as a key marker for individual differences in anxiety.
Exposure to Benzo[b]fluoranthene (B[b]F) impairs ovine oocyte developmental competence by inducing oxidative stress, triggering apoptosis via dysregulated BAX, Caspase3, and BCL2 expression, and suppressing GDF9 and BMP15, ultimately leading to reduced nuclear and cytoplasmic maturation and compromised embryonic development.
This study reveals that prokaryotic 6-4 photolyases utilize a unique tyrosine-mediated electron tunneling bridge and a transient E402-dependent protonation pathway to drive blue-light-triggered FAD photoreduction, while their [4Fe-4S] cluster acts as a short-lived secondary electron injector that rapidly recombines due to the lack of an acceptor.
By developing genetically encoded fluorescent sensors (iKetSnFRs), researchers discovered that ketamine persists within specific intracellular neuronal compartments long after systemic clearance, providing a mechanistic basis for its rapid and sustained antidepressant effects.