5841 papers
While both real and virtual forest exposure improve psychological well-being, only real nature exposure produces significant physiological relaxation benefits, indicating that virtual nature is not a complete substitute for real nature.
This study demonstrates that short-term light perturbations in the Yellow River Estuary rapidly alter the community structure, functional potential, and metabolite profiles of *Synechococcus* and its co-occurring bacterial community, highlighting the dynamic response of estuarine microbial processes to fluctuating light conditions.
This study demonstrates that combining AlphaFold2-guided RosettaRemodel and ProteinMPNN enables the successful engineering of a de novo α-helical barrel biocatalyst with a truncated structure and significantly improved soluble yield, while retaining its core architecture, thermal stability, and catalytic activity despite substantial sequence variability.
This paper establishes that a noisy quantum-classical pipeline based on Constraint-Enhanced QAOA, augmented with shot amplification and deterministic repair, constitutes a fully polynomial randomized approximation scheme (FPRAS) and an -Polynomial-Time Quantum Approximation Scheme (-PTQAS) for constrained optimization, demonstrating a provable quantum advantage over classical samplers and validating the approach on 127-qubit hardware.
This study demonstrates that eight weeks of combined interval swimming training and galantamine administration exerts synergistic neuroprotective effects in rats with post-traumatic stress disorder by significantly reducing inflammation and oxidative stress while enhancing antioxidant capacity, neurotransmitter function, and beneficial microRNA expression compared to either treatment alone.
This study reveals that cancer-associated fibroblast-derived extracellular vesicles carrying cartilage oligomeric matrix protein (COMP) promote ferroptosis resistance and hepatocellular carcinoma progression by enhancing HIF-1α SUMOylation via RANBP2, which subsequently upregulates SLC7A11 expression.
This study demonstrates that CRISPR/Cas9-mediated knockout of the AKAP12 gene in MCF-7/ADR breast cancer cells reverses doxorubicin resistance by impairing proliferation, migration, and survival while promoting apoptosis, suggesting AKAP12 acts as a chemoresistance regulator and a potential therapeutic target.
This study establishes a standardized and reproducible in vitro framework for assessing Aβ1–42 toxicity by integrating a triple-validated neuronal model with controlled peptide aggregation, revealing that toxicity outcomes critically depend on peptide aggregation state, neuronal maturation, and the specific viability assay employed.
This paper proposes an end-to-end evaluation framework for approximate quantum optimization that distinguishes between exact mathematical recovery, surrogate near-optimality, and downstream operational acceptability, demonstrating that defining success by operational consequences significantly alters sampling cost requirements and reveals that, on small inventory-control instances, classical baselines currently outperform QAOA despite these nuanced success metrics.
This study reveals that while local neural dynamics and functional connectivity largely retrace their paths during transitions between consciousness and unconsciousness, global brain organization follows distinct, asymmetric trajectories, indicating that recovery of consciousness is an active process of large-scale network reorganization rather than a simple reversal of anesthetic suppression.