1498 papers
In a randomized, double-blind crossover trial involving 13 young healthy males, acute caffeine ingestion (6 mg/kg) was found to significantly impair the accuracy of low-level force output during incremental contractions compared to a placebo, suggesting it may compromise skills requiring fine force control.
This study analyzes the Tahoe-100M atlas to define an interpretable coordinate system for drug responses based on two nearly independent axes—context-robustness and dose-emergence—and identifies target transcriptional depth as a key mechanistic correlate that organizes these responses, offering a structural audit of drug mechanisms rather than a predictive model.
This study reveals that Feline morbillivirus exhibits gene-specific codon environments and a pervasive, ordered suppression of CpG dinucleotides across its coding genome, suggesting a multiscale evolutionary model where host adaptation and potential immune evasion mechanisms jointly shape viral architecture.
This study reveals that the BBSome regulates ciliary composition by functioning upstream of the ciliary gate to prevent non-ciliary proteins from being mis-loaded onto intraflagellar transport trains, thereby establishing a two-step model of cargo selection and gating.
This study reports the generation of a human scFv phage display library derived from mouse RNA to identify specific antibodies against *Pseudomonas aeruginosa* exotoxin A, aiming to develop diagnostic tools for treating infections in immunocompromised patients.
This paper describes the expansion of the AlphaFold Protein Structure Database to include 1.81 million high-confidence, proteome-scale predictions of homo- and heterodimeric complexes across 4,777 organisms, revealing novel structural topologies and conserved ancient assemblies that significantly extend beyond existing experimental coverage to facilitate functional discovery.
This study presents the high-resolution atomic structure of the novel Type V pilin Ffp1 from *Porphyromonas gingivalis*, revealing a unique quadruple helical assembly and demonstrating its critical role in outer membrane vesicle production and polymicrobial biofilm formation with *Treponema denticola*.
This study reports the discovery and characterization of a novel, evolutionarily distinct haloacid dehalogenase type II enzyme from *Achromobacter mucicolens* that successfully achieves direct, cell-free enzymatic defluorination of perfluorooctanoic acid (PFOA) by cleaving its resilient C-F bonds.
This study demonstrates that quercetin alleviates TNF-α/IFN-γ-induced hyperactivation of keratinocytes, a key feature of atopic dermatitis, by reversing proteomic dysregulation and inhibiting critical immune-inflammatory pathways, particularly NF-κB and STAT1 signaling.
This study reveals that gestational diabetes mellitus placentas exhibit a distinct mitonuclear transcriptional imbalance characterized by the downregulation of mitochondrial-encoded oxidative phosphorylation genes alongside the upregulation of nuclear-encoded counterparts, a phenotype that co-occurs with dysregulation of m6A regulatory genes.