3726 papers
This study identifies a conserved set of 85 age-invariant proteins and transcripts in *C. elegans* that are enriched in biosynthetic and gene expression processes, suggesting their potential utility as reference controls for aging research and biomarker discovery.
This study develops and validates a data-driven, non-linear ODE model to quantify the complex dynamics of drug resistance, macrophage polarization, and immune escape in lung cancer, deriving the basic reproduction number () and identifying key therapeutic parameters through sensitivity analysis and rigorous model selection.
This systematic review of 16 eligible studies found that while 62.5% of research on histopathology image annotation incorporates quality control efforts, the field remains fragmented with implementations varying between quality control measures, features, or a combination of both.
This study presents a novel Ant Colony Optimization-driven framework that identifies a 15-signature chimeric RNA panel capable of predicting organ-specific metastatic destinations with 91.46% accuracy, establishing chimeric RNAs as promising biomarkers for personalized cancer prognosis.
This study demonstrates that nasal exposure to environmental PM2.5 impairs male reproductive function by activating the NLRP3/Caspase-1/GSDMD pyroptosis pathway and an interferon-STAT-driven inflammatory network, effects that are significantly mitigated by Caspase-1 inhibition and validated through both animal models and transcriptomic analysis.
This computational study integrates time-resolved single-cell transcriptomics and functional dependency data to map the staged metabolic reprogramming of drug-tolerant persister cells in EGFR-mutant lung cancer, identifying an NRF2-regulated network that renders these cells specifically vulnerable to GPX4 inhibition.
This study demonstrates that fecal microbiota profiles in Iberian pigs, particularly those collected during mid-fattening, serve as accurate pre-slaughter predictors of carcass fat and fatty acid traits with significant genetic utility for enhancing meat quality in breeding programs.
By employing a cryo-correlative light and electron microscopy workflow, this study reveals that prion-infected neurons exhibit distinct nanoscale pathological features, including fragmented fibrils within membrane compartments and mitochondrial granule accumulation, that are strikingly similar to those observed in Huntington disease models, suggesting shared mechanisms of neuronal dysfunction across neurodegenerative diseases.
This study employs discrete-time modeling and stability analysis to demonstrate that immune escape in tumor-immune dynamics can occur through distinct bifurcation mechanisms, including saddle-node bifurcations and spiral sink-to-source transitions, highlighting that maintaining equilibrium stability is critical for effective tumor control even before equilibrium existence is lost.
This study identifies that chronic stress selectively increases neuronal activity in the superficial layers of the dorsal retrosplenial cortex specifically during REM sleep in a mouse model of depression, suggesting this region plays a key adaptive role in the stress response.