1498 papers
This study demonstrates that while sex differences in opioid responses are consistent in sensory pain processing, affective responses to pain are more variable and minimally influenced by the estrous cycle, with females exhibiting heightened locomotor and vocal reactions to fentanyl compared to males.
This study reveals that chronic cerebral hypoperfusion triggers blood–brain barrier disruption and vascular cognitive impairment through a PARP1–FOXO3a–Depp1 signaling axis that drives excessive autophagy initiation, a mechanism that can be effectively targeted by the PARP1 inhibitor Olaparib.
This study provides genomic and transcriptomic evidence that clinical *Mycobacterium tuberculosis* isolates exhibit greater genome plasticity than previously thought, driven by IS6110-mediated recombination that generates diverse fusion transcripts and DNA-level rearrangements across independent datasets.
This study demonstrates that while static DNA-methylation burden and entropy can effectively classify hematologic malignancy subtypes and distinguish them from healthy donors using public cohort data, such cross-sectional measures are insufficient for inferring individual disease trajectories, necessitating prospective serial sampling to validate lead-time estimation.
This study demonstrates that combining blue cup, scent-bottle, and Malaise traps provides a comprehensive and cost-effective framework for rapid bee inventory and monitoring in the Brazilian Cerrado, revealing high species richness and the critical conservation value of Brasília National Park.
This study reveals that microsporidian genome expansion is primarily driven by endogenous transposable element bursts facilitated by genetic drift, while horizontal gene transfer from hosts plays only a minor, taxon-specific role.
This study identifies a de novo DCLK1 variant as the causative factor of a progressive neurodevelopmental disorder by integrating cross-species functional genomics in C. elegans and patient-derived neuronal analyses to demonstrate that the mutation induces neurite defects and neurodegeneration, which can be partially rescued by wild-type DCLK1 expression or pathway targeting.
This study reveals that while protein language models encode biologically meaningful information that is linearly decodable, they lack the complex low-dimensional manifolds, multi-scale spectral structures, and hierarchical concept geometries found in single-cell foundation models, instead representing knowledge through a geometrically simple, high-linear-dimensional space shaped by the discrete and homology-driven nature of sequence data.
This study utilizes self-organizing map analysis of liver transcriptomics across diverse independent cohorts to identify five distinct, histology-independent MASLD subtypes with unique molecular and immune-stromal profiles, offering a new framework for patient stratification and targeted therapeutic strategies.
This study demonstrates that tunable polyacrylamide-alginate double-network hydrogels, particularly those crosslinked with CaCl₂, successfully replicate the nonlinear, rate-dependent transverse compressive behavior of cervical spinal cord tissue, offering a viable biomimetic surrogate for injury biomechanics and surgical simulation.