5841 papers
This study identifies a SATB2–SELENBP1 transcriptional program that promotes colonic epithelial regeneration, demonstrating that SELENBP1 stabilizes SATB2 via SUMOylation and that methionine restriction enhances this protective mechanism during tissue injury.
This study employs a multi-scale, multimodal imaging approach combining synchrotron-based X-ray phase-contrast tomography and transmission electron microscopy to characterize the 3D distribution, internal architecture, and immune response of tattoo pigments in porcine and human skin, thereby establishing a comprehensive framework for evaluating tattoo ink safety.
This paper presents a high-throughput, single-molecule nanoscale imaging platform that utilizes a dual CRISPR-Cas9 labeling strategy and magnetic-bead enrichment to rapidly, accurately, and reproducibly visualize the full spectrum of telomere lengths at single-molecule resolution using minimal DNA input, thereby overcoming the limitations of conventional population-average assays for aging, cancer, and telomere biology research.
This paper establishes tight query complexity bounds showing a quadratic separation between randomized classical and quantum algorithms for deciding the sign of periodic weighted sums, and provides explicit quantum circuit constructions with concrete resource estimates that validate these theoretical advantages at large scales.
This study demonstrates that persistent HPV16 E7 expression establishes a preconditioned, hyperproliferative, and inflammatory epithelial state with sex-specific transcriptional amplification—particularly in females—that alters the tissue's response to carcinogenic injury by redirecting rather than accelerating the remodelling process during oral carcinogenesis.
This study characterizes MHC class II variation in feral pigeons across five Polish cities, revealing moderate allelic diversity, intraspecific copy number variation, and distinct evolutionary trajectories between the DAB1 and DAB2 gene lineages, thereby highlighting the species' potential for further immunogenetic research.
This paper presents a lightweight convolutional–recurrent neural network that achieves sleep staging accuracy comparable to much larger models using single-channel EEG, demonstrating robust performance in healthy sleepers while showing slightly reduced accuracy for individuals with insomnia.
This proof-of-concept study demonstrates that machine learning models trained on host transcriptomic signatures can effectively classify diverse ocular pathogens (viral, fungal, and bacterial) with accuracy significantly above chance, even under rigorous, study-independent cross-validation, despite current limitations related to dataset provenance.
This study demonstrates that dinotefuran induces significant neurotoxicity, oxidative stress, inflammation, DNA damage, and apoptosis in rainbow trout brains, while the co-administration of aloe-emodin effectively mitigates these adverse effects and promotes partial recovery.
This study characterizes five novel TECTA variants across seven families, demonstrating that recessive hearing loss is driven by splicing defects and specific missense mutations in the zona pellucida domain, while dominant cases result from missense variants in the zonadhesin-like domain that likely cause structural destabilization.