3726 papers
This study provides the first evidence of highly pathogenic avian influenza H5N1 clade 2.3.4.4b circulation in Antarctic Weddell seals, detected through non-invasive fecal sampling and linked to the South American viral lineage, highlighting the need for continued One Health monitoring of Antarctic marine mammals.
This study reveals that respiratory virus RNAs act as competitive sponges for specific host microRNAs, thereby upregulating host factors that enhance viral replication and receptor transport through a power-law regulatory mechanism.
This study demonstrates that topographic wetness heterogeneity within paddy landscapes facilitates the coexistence of two closely related frog species, *Pelophylax porosus brevipodus* and *P. nigromaculatus*, by driving contrasting environmental responses that minimize interspecific competition.
This paper computationally analyzes NR4A3 fusion junctions in extraskeletal myxoid chondrosarcoma to identify in-frame reading frames that retain specific FET-family RGG-rich content, while explicitly noting that the study relies on public transcript data without experimental validation and proposes future falsifiable predictions.
This systematic review of 11 human studies indicates that perinatal depression involves convergent epigenetic alterations across stress, endocrine, circadian, and neurodevelopmental pathways—particularly DNA methylation in genes like NR3C1, TTC9B, and CRY1—though current evidence is limited by small sample sizes and a lack of histone modification data, highlighting the need for longitudinal multi-omics research to validate biomarkers and clarify causal mechanisms.
This paper reviews mathematical models, ranging from deterministic to stochastic approaches, that simulate lung cancer cell growth, tissue invasion, and immune system interactions to predict treatment outcomes and optimize anticancer agent administration.
This study introduces an onto-phylogenetic coordinate system (OPC) that models neurodegenerative tissue vulnerability as a scale-invariant, geometric property of spatiotemporal architecture, demonstrating that diverse TDP-43 proteinopathies (ALS, FTLD-TDP, and LATE-NC) follow deterministic, fractally invariant pathways of least resistance dictated by thermodynamic gradients rather than specific protein characteristics.
This paper presents a partial differential equation-based mathematical model integrating lung cancer cell migration, growth, and tumor-immune interactions to analyze disease dynamics and treatment responses, while also exploring fluid dynamics in obstructed airways and identifying a "Go-or-Grow" mechanism as a key descriptor for specific cell lines.
This study presents iMN1443, a high-quality genome-scale metabolic model of *Cronobacter sakazakii* that elucidates the pathogen's metabolic versatility, reveals a growth-virulence trade-off in host and biofilm environments, and identifies 107 essential genes as potential antimicrobial targets.
This study demonstrates through coarse-grained kinesin-1 simulations that molecular motor robustness arises not from error-free microscopic steps, but from local stochastic trials combined with conditional gating mechanisms that effectively control the propagation of errors to prevent catastrophic failure.