5841 papers
This paper proposes a novel theoretical loophole in electrostatics to explain the electron handoff mechanism in Complex I of the electron transport chain, supporting this hypothesis with experiments using mutant bacteria and discussing its potential implications for understanding mitochondrial disorders.
This study demonstrates that short-term exposure to acidic conditions significantly reduces the viability of *Escherichia coli* K-12 more than basic conditions or temperature variations, which showed no statistically significant effect on survival.
This study demonstrates that soluble TREM2 (sTREM2) acts as a rapid, physiological suppressor of neuronal activity by binding to CD73 to activate purinergic microglia–neuron signaling, thereby protecting against excitotoxicity and offering a potential therapeutic target for Alzheimer's disease and epilepsy.
This study identifies CAV1 and PECAM1 as core targets mediating the association between Di(2-ethylhexyl) phthalate (DEHP) exposure and lung adenocarcinoma immune microenvironment remodeling through integrated bioinformatics analysis, machine learning, and molecular simulations.
This study presents the first whole-genome characterization of a distinct *Mammaliicoccus sciuri* sequence type 605 isolated from subclinical mastitis in a Bangladeshi swamp buffalo, revealing a novel early-diverging lineage with a purely intrinsic antimicrobial-resistance repertoire that contrasts with multidrug-resistant human and poultry-associated strains.
In a cohort of children with obesity from eastern Türkiye, a population characterized by frequent consanguinity, genetic testing revealed a 35.6% diagnostic yield dominated by autosomal recessive conditions like Bardet–Biedl syndrome, with parental consanguinity identified as the strongest predictor of a molecular finding.
This paper proposes and benchmarks a symmetry-preserving continuous-time quantum walk framework for protein conformational sampling, demonstrating that while it achieves detailed balance and mixing comparable to classical methods on small hydrophobic–polar lattice models, it does not currently exhibit a quantum speedup over classical diffusion.
Using computational fluid dynamics on three-dimensional electron microscopy data, this study quantified the extracellular space permeability in rat, mouse, and human brains to be approximately 10 nm², establishing a recommended range of 10–100 nm² for physiological modeling across these species.
This study reveals that postglacial differentiation between migratory and boreal caribou ecotypes in eastern Canada is driven by recent, incomplete soft selective sweeps on standing genetic variation affecting traits like bone development and energy metabolism, rather than by classic hard sweeps or complete reproductive isolation.
This study proposes the novel species *Exiguobacterium sargassi* sp. nov., a glycoside-hydrolase-enriched bacterium isolated from the seaweed *Sargassum henslowianum* in Vietnam, based on comprehensive phenotypic, chemotaxonomic, and genomic evidence distinguishing it from its closest relative, *E. qingdaonense*.