3726 papers
This study demonstrates that rutin-loaded chitosan/guar gum nanoparticles, developed via ionic gelation, significantly enhance the solubility, stability, and targeted delivery of rutin to ovarian cancer cells, resulting in superior cytotoxicity and apoptosis induction compared to free rutin.
This study validates the feasibility of using fish as bioreactors for recombinant protein production by demonstrating that a novel lipocalin family gene promoter from black rockfish can drive androgen-dependent expression of fluorescent proteins in the kidneys of transgenic medaka, allowing for their collection from urine and rearing water.
This multi-omics study reveals that the MTOR1-HIF1α axis drives distinct fibroblast subpopulations (ADAM28+ in MSI-H and COL1A2+ in MSS) that dictate the immunological landscape of colorectal cancer, identifying AZD2014 as a therapeutic candidate to remodel the immunosuppressive MSS stroma by reversing fibroblast fate.
ProStructLab is an open-access, browser-based platform that enables interactive analysis of protein residue networks through visualization, communication-hub identification, and topological perturbation tools, demonstrating distinct structural signatures for catalytic, allosteric, and interface residues without requiring programming expertise or molecular dynamics simulations.
This study establishes a correlation between the developmental stages of *Scutellaria baicalensis* microspores and specific floral organ characteristics, demonstrating that flower bud size and anther color can serve as reliable indicators for identifying the optimal microspore stage for anther and microspore culture.
This study establishes that the N-terminal α1 domain of NINJ1 is essential for mediating plasma membrane rupture but dispensable for embryonic development, enabling the creation of hydrocephalus-free mouse models (Ninj1K45Q/K45Q) that retain the ability to attenuate cell lysis and accelerate research into inflammatory diseases.
This study reveals that adolescents with unilateral cerebral palsy exhibit altered visuomotor oscillatory activity characterized by the affected hand being predominantly controlled ipsilaterally by the intact hemisphere and reduced attentional prioritization for stimuli in the affected hemispace, yet these motor and visual processes remain tightly coupled through adapted integration mechanisms.
This study demonstrates that progressive endothelial dysfunction and an endothelial-to-mesenchymal transition (EndMT)-like phenotype are shared pathological features in both familial and sporadic cerebral cavernous malformations, validating patient-derived endothelial models for investigating disease mechanisms and therapeutic strategies.
This study reveals that in *Saccharomyces cerevisiae*, the pyruvate dehydrogenase complex (PDHc) functions as a non-catalytic, RNA-dependent structural component that physically associates with mtDNA and mitoribosomes to support mitochondrial translation and genome maintenance, a role distinct from its canonical metabolic function in acetyl-CoA synthesis.
This study demonstrates that in healthy men, circulating propionate mediates the relationship between specific propionate-producing gut microbial genera and physiological stress responses via the HPA axis, while other genera like *Faecalibacterium* and *Dialister* are distinctly associated with self-reported stress and negative affect.