🧬 Category

q-bio

5841 papers

🧬 biology

An Integrated One-Click Python Pipeline for Bacterial Codon-Usage Analysis and Proteome-Wide Characterization

This paper presents an integrated, one-click Python pipeline that streamlines bacterial codon-usage and proteome-wide characterization by combining sequence-quality filtering, nucleotide and codon indices, and protein physicochemical properties into a single reproducible workflow, while acknowledging the need for further benchmarking to address discrepancies arising from computational definitions and reference sets.

Ujwal Dahal2026-10-28
🧬 biology

A duplicated Hedgehog ligand and a duplicated Patched receptor show different constraint and genomic context in land snails and slugs

This study reveals that in land snails and slugs, duplicated Hedgehog ligand and Patched receptor genes exhibit distinct evolutionary trajectories, with Hedgehog copies undergoing relaxed constraint and rapid divergence in a specific domain, while Patched copies remain strongly conserved and syntenic, highlighting that proteome-based inventories can underestimate gene copy numbers.

Zhi-Jie Xu2026-10-28
🧬 biology

Effects of DDX58 Gene Knockdown on EV-A71 Replication and Modulation of RIG-I–Mediated Antiviral

This study demonstrates that DDX58 (RIG-I) knockdown in RD cells unexpectedly suppresses EV-A71 replication while inducing a transient, time-dependent activation of downstream antiviral signaling and interferon production, suggesting a complex, context-dependent regulatory role and potential compensatory immune mechanisms.

Guo-E Gou, Mei Li, Meng Zhang, Xin-Yu Wang, Wen Zhang, Song Zhai, Mu-Qi Wang, Chen-Rui Liu, Ting Li, Ya-Ping Li2026-10-28
🧬 biology

Supramammillary projections to the lateral preoptic area regulate active behavior and dopamine release

This study reveals that the supramammillary nucleus-to-lateral preoptic area (SuM→LPO) pathway is a distinct circuit that, through glutamatergic signaling and dopamine release in the nucleus accumbens, promotes active behavioral responding to environmental challenges while inhibiting consummatory behaviors.

Satoshi Ikemoto, Yosuke Arima, Zengyou Ye, Coleman Calva, Xia Min, John Gibbons, Jorge Mendoza, Beyonce Getachew, Sarah (…)2026-10-28
🧬 biology

Biogas biodesulfurization and simultaneous valorization into high–value bioproducts by Rhodopseudomonas telluris

This study demonstrates that *Rhodopseudomonas telluris* effectively removes hydrogen sulfide from biogas through complete oxidation while simultaneously producing high-value bioproducts, including carotenoids, bacteriochlorophylls, and polyhydroxybutyrate, thereby offering a sustainable circular economy solution for biogas purification.

Sergio Cisneros de la Cueva, Virginia Montiel Corona, Francisco Javier Choix Ley, Cesar Soto Figueroa, Iván Salmerón Och (…)2026-10-28
🧬 biology

Seed Nutritional Traits and Bird Feeding Preferences: Laboratory Evaluation with an Exploratory Quantitative Literature Synthesis

This study combines laboratory analysis of seed nutritional and defensive traits with a quantitative literature synthesis to demonstrate that while avian feeding preferences are positively associated with protein levels and negatively associated with phenolic compounds, the specific trade-offs between chemical defenses and physical handling resistance ultimately shape the availability of nutrient-rich seeds for granivorous birds.

deng chaochao, Yingxuan Fan, Guanghui Ma2026-10-28
🧬 biology

An agent-based 3D model of non-genetic adaptation in cancer tissues under electrical, mechanical, and hypoxic stress

This study presents an agent-based 3D model demonstrating how the interplay of electrical, mechanical, and hypoxic stresses drives non-genetic adaptation in cancer tissues, revealing that both the magnitude and temporal pattern of physical cues critically shape tumor growth dynamics, necrosis, and the accumulation of adapted cell populations.

João Ferreira Gil, Nathalia Pinheiro, Saverio Gentile, Gil Gonçalves, Rosalia Moreddu2026-10-28
🧬 biology

Experimental Study on Hydrodynamic Preferences and Collective Behavior of Fish Groups During Upstream Migration in Non-Uniform Flow

This study demonstrates that *Schizothorax prenanti* groups maintain high-order schooling and navigate complex non-uniform flows by compressing their formation and preferring low-velocity corridors, providing critical insights for optimizing fish passage facility design to better support collective upstream migration.

Bo-yu Chen, Sheng-liang Wu, Jia Li, Dan-lin Peng, Gu-peng Zhang, Xi-liang Tang, Jiang Yu, Ruidong An2026-10-28