3726 papers
This study reveals that nanoplastics induce spatially restricted RNA–protein reorganization and P-body dynamics in epithelial cells, distinct from whole-cell stress responses, and demonstrates that targeting locally enriched RNA motifs can mitigate these effects and improve cell viability.
This study characterizes the newly isolated halotolerant plant growth-promoting rhizobacterium *Kosakonia cowanii* strain T6-2, demonstrating through integrated genomic and functional analyses that it mitigates salt stress via specific osmoprotectant accumulation and ion transport mechanisms while enhancing crop growth and nutrient availability in saline agroecosystems.
This study reveals that MG53 protects against vascular remodeling by inhibiting smooth muscle cell proliferation and glycolysis through a novel mechanism involving the formation of a complex with P300 to promote the acetylation and suppression of LDHA, independent of its canonical E3 ligase activity.
This study presents a biomimetic, perfusable three-dimensional polyurethane scaffold with brain-mimetic mechanical properties and interconnected pores that supports the long-term formation, viability, and drug-responsive growth of U87 glioblastoma multicellular tumor spheroids for advanced tumor microenvironment modeling and preclinical therapeutic screening.
This study demonstrates that a within-subject fMRI design for delay eyeblink conditioning is feasible for future treatment research, as it successfully elicited comparable behavioral and neural learning effects across two sessions in healthy participants, despite the need to account for session effects and learning transfer.
This study revises the taxonomy of the Colwelliaceae family by establishing two new genera and reclassifying 24 genera into 32, while demonstrating that cold adaptation in these marine bacteria arises from lineage-specific combinations of genomic features rather than a single universal mechanism.
This study introduces a compartment-resolved brain age framework that distinguishes vascular-metabolic aging in white matter from neurodegenerative aging in gray matter, revealing that white matter age is driven by cardiometabolic risks and tau pathology while offering insights beyond traditional gray matter estimates.
This study demonstrates that in progressive systems like periodontitis, the specific assumptions used to reconstruct missing component data significantly influence inferred network topology and stability, revealing that high reproducibility alone does not guarantee substantive plausibility.
This study demonstrates that the methanolic extract of a Mediterranean marine *Anabaena* strain exhibits broad-spectrum antimicrobial activity against various bacterial and fungal pathogens, a property attributed to twenty identified bioactive lipid-derived metabolites, primarily fatty acids and their derivatives, as revealed by GC–MS analysis.
This study integrates multi-omics analyses and experimental validation to demonstrate that in pulmonary arterial hypertension, endothelial mechanotransduction drives the upregulation of circadian clock genes CRY1 and CLOCK through a TEAD-dependent YAP/TAZ signaling axis.