3726 papers
This study demonstrates that the antagonistic interaction between apical (Crb1/2) and basal (Lgl1) polarity complexes regulates cortical development by converging on Hippo-Yap signaling to control cell cycle kinetics, thereby preventing epithelial disruption and ectopic proliferation.
This study demonstrates that thrombolytic ex-vivo machine perfusion rescues extended uncontrolled donation after circulatory death porcine kidneys by clearing microvascular obstructions and reprogramming the proteome toward a functional state that converges with live-donor controls, thereby mitigating ischemic injury and preventing fibrosis.
This study demonstrates that pasteurized fermented milks containing *Bifidobacterium animalis* subsp. *lactis* ProbioM8, *Lactobacillus paracasei* PC01, or their combination alleviate DSS-induced colitis in mice by modulating specific intestinal metabolites, restoring gut barrier function, and regulating distinct inflammatory and metabolic pathways.
This study utilizes a large-scale single-nucleus RNA-sequencing atlas to reveal that Frontotemporal Dementia selectively targets specific inhibitory and RNF220+ excitatory neuronal populations in the human thalamus while sparing RNF220- excitatory neurons, identifying intrinsic molecular programs such as cytoskeletal maintenance and elevated progranulin expression that confer resilience against neurodegeneration.
This study demonstrates that TDP-43 phase separation governs its protein interactome and alternative splicing regulation, as evidenced by the discovery that mutations altering condensate dynamics differentially modulate interactions with key RNA regulatory factors.
This study demonstrates that using an estradiol-inducible Cre/loxP system to temporally excise the morphogenic regulator PIWUS-IPT at 3 days post-cocultivation resolves the trade-off between high transformation efficiency and developmental defects in tobacco, yielding normal plants with a 1.35-fold increase in overall efficiency and enhanced genome editing outcomes.
This study reveals that chlorogenic acid modulates the digestibility and allergenicity of soybean 7S globulin through distinct mechanisms, where noncovalent binding enhances proteolytic clearance of antigenic fragments while covalent conjugation masks IgE epitopes, offering a strategic framework for designing hypoallergenic soybean ingredients.
This study demonstrates that unsaturated fatty acid-rich diets in *Drosophila melanogaster* accelerate pre-adult development and increase larval activity while reducing pupariation height and survivorship, indicating a developmental plasticity that decouples normally linked life-history traits.
This study demonstrates that ethanolic extracts of sweet orange peels and seeds exhibit concentration-dependent antibacterial activity against *Staphylococcus aureus* and *Escherichia coli*, with peel extracts showing the strongest effect, thereby validating the potential of these agro-waste residues as a low-cost source of antibacterial compounds.
This study demonstrates that in boreal spruce forests, the abundance of parasitoid wasps is shaped by a complex interplay of forest management history, dead wood heterogeneity, and scale-dependent landscape connectivity, with near-natural forests generally supporting higher abundances of diverse functional groups compared to formerly clear-cut sites.