q-bio papers | Gist.Science

Attenuation of typical sex differences in the time-resolved functional connectivity of the fusiform gyrus in autism

This study utilizes micro co-activation patterns analysis on resting-state fMRI data to reveal that autism is characterized by an attenuation and reversal of typical sex differences in the dynamic functional connectivity and spatial extent of fusiform gyrus subregions coupled with the default mode network, highlighting sex as a critical dimension of neurobiological heterogeneity in social cognition.

Dorothea Floris, Luigi Saccaro, Farnaz Delavari, Dawid Strzelczyk, Bruno Hebling Vieira, Camille Elleaume, Charlotte Pre (…)2026-07-22

🧬 biology

A genomic history of African cattle

By analyzing whole-genome sequences from nearly 5,000 African cattle, including ancient samples, this study reveals that the continent's cattle represent a complex mosaic of distinct taurine and indicine lineages whose geographic distributions and evolutionary trajectories have been uniquely shaped by contrasting human subsistence strategies, specifically the sedentary farming of taurine breeds versus the mobile pastoralism driving indicine dispersal.

Laurent Frantz, Said Ng'ang'a, James Ward, Gillian McHugo, Mica Jones, Olaf Thalmann, Mbunkah Achukwi, Adeniyi Adeola, T (…)2026-07-22

🧬 biology

Optimizing a Human Forensic STR Panel for Non-Invasive Genetic Monitoring of Chimpanzees (Pan troglodytes)

This study presents a standardized framework for adapting the human GlobalFiler™ forensic kit to chimpanzee genotyping, successfully optimizing a 16-locus panel from non-invasive samples in Cameroon that achieves high amplification success and discriminatory power for individual identification and conservation monitoring.

Shrutarshi Paul, Fabrice Kentatchime, Tyler Andres-Bray, Tista Ghosh, Giovana Naira Pereira Couto, Kevin Njabo, Mary Kat (…)2026-07-22

🧬 biology

AlphaFold-derived local structural confidence in BRCA1 missense variant interpretation: a ClinVar-based computational analysis

This study demonstrates that AlphaFold-derived local structural confidence (pLDDT) scores are strongly associated with the clinical classification of BRCA1 missense variants, suggesting that pLDDT serves as a valuable contextual tool for refining the interpretation of variants of uncertain significance alongside existing computational predictors.

Yaroslav Yasinskyi, Mariana Chopei, Andrei Sivolob2026-07-22

🧬 biology

Decoding Overlapping Lower-Limb Afferent Pathways from Human Epidural Spinal Recordings

This study demonstrates that clinical-grade lumbosacral epidural arrays can successfully decode distinct overlapping common fibular and tibial nerve afferent signals in humans with high accuracy, establishing a viable pathway for rapid, closed-loop neuromodulation without the need for invasive penetrating or peripheral interfaces.

Alexander Steele, Milton Candela, Gracie Hufft, Amanda Howes-Keith, Catherine Martin, Jeonghoon Oh, Amir Faraji, Dimitry (…)2026-07-22

🧬 biology

CRISPR/Cas9-mediated miR-155 knockout suppresses glioblastoma cell proliferation through TP53INP1/p53/p21 activation

This study demonstrates that stable CRISPR/Cas9-mediated knockout of miR-155 suppresses glioblastoma cell proliferation by activating the TP53INP1/p53/p21 signaling axis, while exerting only limited and heterogeneous effects on other malignancy-associated traits such as migration and invasion.

Jung Bae Seong, Se-Hee Choe, Wi-Jae Lee, Sang-Je Park, Junghyung Park, Hyoung-Chin Kim, Jae-Won Huh, Seung Hwan Lee, Yeo (…)2026-07-22

🧬 biology

Genome-wide identification and characterization of the MADS-box gene family in Rosa chinensis

This study presents a comprehensive genome-wide analysis of the *Rosa chinensis* MADS-box gene family, identifying 75 members, characterizing their structural and evolutionary features through phylogenetic and synteny analyses, and providing a foundational resource for future functional investigations into rose development and stress responses.

Tingting Sun2026-07-22

🧬 biology

State and trait anxiety modulate hemodynamic amygdala responses to innocuous auditory stimulation

This study demonstrates that higher state and trait anxiety levels are associated with heightened right amygdala responses to neutral auditory stimuli, indicating a modality-specific increase in vigilance toward innocuous sounds rather than visual cues.

Despina Kartsaki, Martina-Trisia Cinca-Tomás, Emmanouela Kosteletou-Kassotaki, Mara Cean, Debora Lombardo, Judith Domíng (…)2026-07-22

🧬 biology

Transient Receptor Potential Vanilloid 1 (Trpv1) Receptors Are Expressed by Parietal Cells in the Rat Stomach Fundus and Antrum

This study utilized RT-PCR, sequencing, and GeneBlast analysis to confirm the expression of Transient Receptor Potential Vanilloid 1 (TRPV1) receptors in the fundus and antrum of the rat stomach.

Shyamal Premaratne, Hansa Doppalapudi, Nuveena S. Sooriya, Morgan B. Edwards, Mitchell L. Schubert2026-07-22

🧬 biology

E2IATLAS: A Normative Database of Nature Images with Affective and Self-Transcendent Emotion Ratings

The paper introduces E2IATLAS, a comprehensive normative database of 3,161 nature images rated by over 2,000 global participants, which reveals a distinct three-factor emotional structure dominated by positive transcendence and identifies environmental distress imagery as a unique profile that elicits compassion despite negative valence.

Carmen Morawetz2026-07-22

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