1432 papers
By combining magnetoencephalography with electrodermal activity during a sustained-threat task, this study reveals that specific cortical oscillatory patterns precede sympathetic arousal and that the strength of this neural–autonomic coupling, rather than cortical power or arousal levels alone, serves as a key marker for individual differences in anxiety.
Exposure to Benzo[b]fluoranthene (B[b]F) impairs ovine oocyte developmental competence by inducing oxidative stress, triggering apoptosis via dysregulated BAX, Caspase3, and BCL2 expression, and suppressing GDF9 and BMP15, ultimately leading to reduced nuclear and cytoplasmic maturation and compromised embryonic development.
This study reveals that prokaryotic 6-4 photolyases utilize a unique tyrosine-mediated electron tunneling bridge and a transient E402-dependent protonation pathway to drive blue-light-triggered FAD photoreduction, while their [4Fe-4S] cluster acts as a short-lived secondary electron injector that rapidly recombines due to the lack of an acceptor.
By developing genetically encoded fluorescent sensors (iKetSnFRs), researchers discovered that ketamine persists within specific intracellular neuronal compartments long after systemic clearance, providing a mechanistic basis for its rapid and sustained antidepressant effects.
This study identifies novel spiro[indoline-tetrazolo[1,5-c]quinazoline] derivatives as promising non-hydroxamate HDAC8 inhibitors through molecular docking and ADMET analysis, demonstrating superior binding scores and favorable cytotoxicity profiles driven by specific pharmacophoric interactions that may offer improved selectivity and reduced toxicity compared to conventional inhibitors.
This global meta-analysis reveals that urbanization causes substantial wetland biodiversity loss and compositional shifts—particularly affecting river and amphibian communities—while highlighting critical knowledge gaps in tropical and low-income regions.
Quantitative lung intravital imaging reveals that mechanical confinement during pulmonary capillary transit triggers GsMTx4-sensitive calcium signaling and nuclear remodeling in neutrophils, leading to the formation of motile anuclear cytoplasts that preferentially engage *Pseudomonas aeruginosa*, thereby establishing the capillary bed as a mechanical checkpoint for early host–microbe interactions.
The paper introduces TheMol, a 3D molecular representation framework that learns a canonical frame to decouple global pose from representation learning, enabling a single unified model to effectively handle diverse tasks like property prediction, coordinate generation, and structure-based optimization while improving rotational stability and latent-space structure.
This study utilizes micro co-activation patterns analysis on resting-state fMRI data to reveal that autism is characterized by an attenuation and reversal of typical sex differences in the dynamic functional connectivity and spatial extent of fusiform gyrus subregions coupled with the default mode network, highlighting sex as a critical dimension of neurobiological heterogeneity in social cognition.
By analyzing whole-genome sequences from nearly 5,000 African cattle, including ancient samples, this study reveals that the continent's cattle represent a complex mosaic of distinct taurine and indicine lineages whose geographic distributions and evolutionary trajectories have been uniquely shaped by contrasting human subsistence strategies, specifically the sedentary farming of taurine breeds versus the mobile pastoralism driving indicine dispersal.