3726 papers
This study reveals that *Arctica islandica* populations in the German Baltic Sea exhibit high mitochondrial diversity and a history of postglacial expansion without significant regional genetic structuring, indicating they share widespread lineages with the broader amphi-Atlantic species range despite inhabiting distinct brackish environments.
This study reveals significant ancestry-associated differences in the distribution of inflammatory gene variants (IL6, IL1B, and TNF) between Mexican Mestizo and Indigenous populations, with Indigenous groups showing lower frequencies of risk alleles compared to Mestizos and Europeans, thereby underscoring the necessity of ancestry-informed approaches for assessing inflammatory disease susceptibility.
This study demonstrates that integrating interpretable machine learning models with routine cycle threshold (Ct) molecular data from *Mycobacterium tuberculosis* isolates in rural Eastern Cape can accurately predict drug resistance patterns and identify key genetic drivers, offering a scalable framework to enhance tuberculosis management in high-burden, resource-limited settings.
This study integrates multi-omics data to identify an APOD-EFEMP1-COL5A2 fibroblast programme in gastric cancer that defines a matrix-remodelling, vascular, and myeloid-associated niche linked to adverse clinical outcomes and suggests testable mechanistic hypotheses for therapeutic intervention.
This study establishes a robust molecular traceability system for authenticating edible *Rosa rugosa* and distinguishing it from adulterants by integrating chloroplast genomic analysis, ITS2 DNA barcoding with secondary structure, and chemical profiling to address supply chain traceability and quality screening needs.
This study demonstrates that thermal landscapes reshape the movement of endangered hirola antelope through predictable, nonlinear transitions among distinct behavioral states—specifically a shift toward resting above a 33°C threshold—rather than a uniform suppression of activity, offering a mechanistic framework for predicting wildlife responses to climate change and guiding conservation strategies.
This study utilized CRISPR/Cas9 technology to generate LXRα, LXRβ, and dual knockout MCF-7 breast cancer cell lines, demonstrating that the loss of LXR function disrupts the regulation of target genes like ABCA1 and ABCG1 while increasing basal cell proliferation and reducing sensitivity to LXR agonist-induced growth inhibition.
By utilizing distributed acoustic sensing on submarine cables, researchers revealed that singing fin whales in the Gibraltar-Alboran corridor exhibit seasonal vocal plasticity and bidirectional movement, suggesting the strait serves as both a migratory and social bottleneck.
This study reveals that ALDOB modulates β-cell insulin secretion in type 2 diabetes by interacting with IGFBP5 to regulate GNAI2 transcription and tune GLP-1R-cAMP-PKA signaling, offering a potential therapeutic strategy to overcome GLP-1R desensitization.
This study demonstrates that while standard fecal sample storage variations up to 11 days preserve microbial community integrity, extreme treatments like autoclaving and UV exposure cause catastrophic DNA degradation and artifactual community shifts, thereby validating flexible handling protocols for large-scale microbiome research.