3726 papers
This study demonstrates that the initial conformational state of amyloid-β42 monomers significantly dictates their structural evolution and membrane association dynamics at a POPC interface, highlighting the critical importance of starting-structure selection in modeling early amyloid-membrane interactions.
This study successfully established and characterized two stable gemcitabine-resistant cholangiocarcinoma cell lines derived from intrahepatic and extrahepatic origins, revealing that while both share metabolic and inflammatory adaptations, they activate distinct core regulatory pathways during the development of drug resistance.
This study integrates bidirectional Mendelian randomization, multi-omics analyses, and spatial transcriptomics to establish a causal link between oral microbiome dysbiosis and periodontitis, identifying the downregulation of the host gene ANK3 in periodontal ligament stem cells as a key mechanism underlying tissue destruction.
This study presents a rapid, sensitive, and instrument-independent RT-RPA-CRISPR/Cas14a1 assay for the specific detection of the emerging RHDV2 variant, which demonstrates high concordance with conventional RT-qPCR and holds significant potential for field-based surveillance.
This study employed an integrated computational approach, including 2D-QSAR, molecular docking, and MD simulations, to design and evaluate indole-2-carboxamide derivatives as potential MmpL3 inhibitors, identifying compound 17c as a promising candidate with superior binding affinity and favorable pharmacokinetic properties despite the need for future experimental validation.
This study utilizes genome-wide data from five individuals at the Early Bronze Age Łęki Małe cemetery in Poland to reconstruct a two-generation pedigree, revealing that elite funerary practices selectively foregrounded biological kinship through variable modes of inclusion, such as symbolic representation and whole-body interment, thereby structuring social identity around specific biographical relationships rather than normative kinship structures.
This study elucidates how gene duplication, positive selection, and the co-evolution of the MAF-family transcription factor NRL with OTX-family proteins and their cis-regulatory elements drove the emergence and stabilization of mammalian rod photoreceptors, enabling their survival through the Mesozoic era.
This study utilizes multi-marker DNA metabarcoding (ITS2 and Cox1) to characterize non-fungal eukaryotic diversity in Svalbard's glacial forefields, revealing that community composition and diversity are strongly structured by environmental gradients such as temperature, pH, and organic carbon content along the primary succession chronosequence.
This study integrates bioinformatics, Mendelian randomization, and in vitro experiments to identify SRPK1 and SEM1 as key polyamine metabolism-related genes in non-small cell lung cancer, demonstrating that SRPK1 promotes tumor progression by regulating ODC1 and SAT1 and highlighting its potential as a diagnostic biomarker and therapeutic target.
This study proposes replacing the insufficient energy-density-based dosimetry in laser therapy with a physiologically grounded, damage-based framework by utilizing a Monte Carlo-integrated optical-thermal model and the Arrhenius equation to demonstrate that biological outcomes depend on the specific time course of temperature and tissue sensitivity rather than total energy alone.