🧬 Category

q-bio

5835 papers

🧬 biology

Transcutaneous auricular vagus nerve stimulation alleviates pain–depression comorbidity in mice through dorsal raphe–central amygdala serotonergic signaling

This study demonstrates that transcutaneous auricular vagus nerve stimulation (taVNS) alleviates pain-depression comorbidity in mice by activating a specific neural pathway where serotonergic neurons in the dorsal raphe nucleus project to the central amygdala, thereby restoring serotonin transmission and modulating 5-HT1A receptors to reverse both sensory hypersensitivity and depressive-like behaviors.

Haohan Zhu, Zijie Chen, Xingke Song, Yifei Wang, Xue Pu, Jinling Zhang, Xianghong Jing, Hanlai Zhang, Peijing Rong, Juny (…)2026-10-28
🧬 biology

A C57BL/6NJ Congenic Background Delays Neurodegeneration, Gliosis and Synaptic Loss in the PS19 Tauopathy Model

This study demonstrates that placing the PS19 tauopathy mouse model on a metabolically intact C57BL/6NJ congenic background significantly delays the onset and progression of tau pathology, gliosis, and synaptic loss, thereby providing a more reliable model with greater temporal resolution for preclinical research.

Neha Basheer, Giacomo Siano, Julien Weber, Shahid Ullah Zadran, Petr Novak, Norbert Zilka, Senthilvelrajan Kaniyappan2026-10-28
🧬 biology

Multilevel balancing of laccase biosynthesis and secretion in Bacillus subtilis enables efficient tobacco straw delignification

This study demonstrates that a multilevel engineering strategy in *Bacillus subtilis*, involving the optimization of transcription, translation, and secretion signals, significantly enhances extracellular laccase production to achieve efficient biological delignification of tobacco straw.

Hailin Zhang, Zhendong Li, Xueqin Lv, Chang Liu, Jian Mao, Jingjing Liu2026-10-28
🧬 biology

SeAMT1;2a and SeAMT1;2b from the halophyte Salicornia europaea play dual roles in ammonium transport and salt tolerance

This study identifies and characterizes SeAMT1;2a and SeAMT1;2b as key ammonium transporters in the halophyte *Salicornia europaea* that not only facilitate efficient nitrogen uptake under saline conditions but also independently enhance salt tolerance, likely through potassium homeostasis, highlighting their potential for phytoremediation.

Jinbiao Ma, Zitong Ou, Umashankar Chandrasekaran, Yinan Yao, Xinlong Xiao2026-10-28
🧬 biology

Pronounced lignin variation in a decades-old ex vitro collection of Cereus hildmannianus somaclones

This study reveals substantial heterogeneity in lignin content among decades-old *Cereus hildmannianus* somaclones, demonstrating that biochemical variation persists alongside previously documented morphological and molecular diversity in long-term ex vitro collections.

Silvana Alves Rosa, Felipe Francisco Santos Dias, Diego Eduardo Romero Gonzaga, Maria de Fátima Pires da Silva Machado (…)2026-10-28
🧬 biology

Rhizobacterial genetic diversity associated with Paspalum atratum and Paspalum notatum by metagenomic analysis

Metagenomic analysis of the rhizospheres of *Paspalum atratum* and *Paspalum notatum* reveals distinct, species-specific bacterial community compositions driven by soil pH, with *Acidobacteriaceae* dominating *P. atratum* and *Nitrosomonadaceae* characterizing *P. notatum*.

Ailton Ferreira de Paula, Paulo Henrique Marques de Andrade, Euclides Matheucci, Marcelo Falsarella Carazzolle, Lucas Mi (…)2026-10-28
🧬 biology

Accessory-genome diversity and contrasting genotype–phenotype relationships in ten porcine Streptococcus suis isolates representing five serotypes

This study integrates comparative genomics and experimental phenotyping of ten *Streptococcus suis* isolates to reveal that while specific resistance genes strongly predict antimicrobial susceptibility, classical virulence markers fail to accurately rank pathogenicity, underscoring the need to combine genomic data with phenotypic assays and expand pathogenicity assessments beyond serotype 2.

Hongqiao Lai, Hengzhi Zhu, Zenghao Xiang, Na Li, Jingze Song, Yonghong Qu, Kongwang He, Jiaqiang Niu, Libin Wen, Qi Xiao2026-10-28
🧬 biology

Host taxonomy and temperature differentially shape gut microbiome assembly in tropical moths across an Andean-Amazonian Mountain gradient

This study reveals that host taxonomy and temperature differentially shape the gut microbiome assembly of six tropical moth genera across a Peruvian Andean-Amazonian elevational gradient, with microbial diversity unexpectedly increasing at higher elevations.

Andrea Pinos, Yenny Correa-Carmona, Kim L. Holzmann, Pedro Alonso-Alonso, Andreas Brachmann, Felipe Yon, Gunnar Brehm, I (…)2026-10-28
🧬 biology

Metabolic engineering of Escherichia coli to enhance L-serine biosynthesis

This study enhances industrial L-serine production in *Escherichia coli* by systematically engineering the parental strain H5 to delete re-uptake genes and optimize biosynthetic, transport, and cofactor modules, ultimately achieving a 71.84% yield increase to 0.48 g/g through strain H8-abc and medium optimization.

Kaitai Xiao, Yamin Huang, Meijuan Xu, Guoqiang Xu, Xiaojuan Zhang, Hui Li, Jingsong Shi, Zhenghong Xu, Xiaomei Zhang2026-10-28