1432 papers
This study presents the high-resolution atomic structure of the novel Type V pilin Ffp1 from *Porphyromonas gingivalis*, revealing a unique quadruple helical assembly and demonstrating its critical role in outer membrane vesicle production and polymicrobial biofilm formation with *Treponema denticola*.
This study reports the discovery and characterization of a novel, evolutionarily distinct haloacid dehalogenase type II enzyme from *Achromobacter mucicolens* that successfully achieves direct, cell-free enzymatic defluorination of perfluorooctanoic acid (PFOA) by cleaving its resilient C-F bonds.
This study demonstrates that quercetin alleviates TNF-α/IFN-γ-induced hyperactivation of keratinocytes, a key feature of atopic dermatitis, by reversing proteomic dysregulation and inhibiting critical immune-inflammatory pathways, particularly NF-κB and STAT1 signaling.
This study reveals that gestational diabetes mellitus placentas exhibit a distinct mitonuclear transcriptional imbalance characterized by the downregulation of mitochondrial-encoded oxidative phosphorylation genes alongside the upregulation of nuclear-encoded counterparts, a phenotype that co-occurs with dysregulation of m6A regulatory genes.
This study utilizes a haplotype-based framework to analyze three decades of wheat breeding data in the Northern Plains, revealing that Fusarium head blight resistance is highly polygenic and has improved through the directional selection of multiple small-effect resistance alleles without compromising local genetic diversity.
This study demonstrates that social stress in zebrafish induces anxiety-like behaviors and oxidative stress in subordinate individuals, which are reversed by the 5-HT1A receptor agonist 8-OH-DPAT, suggesting that the drug's efficacy is modulated by social hierarchy through receptor desensitization and sensitization.
This study characterizes SNAPC4-related neurodevelopmental disorder as a heterogeneous, stage-dependent spliceosomopathy caused by loss-of-function variants that destabilize the SNAPc complex and disrupt snRNA transcription, leading to a wide spectrum of clinical and neuroimaging abnormalities.
By integrating ancestral sequence reconstruction with structure-guided mutagenesis, researchers successfully engineered the *Aspergillus oryzae* reductive aminase to achieve significantly enhanced catalytic activity and thermostability in variants Anc74_7 and Anc75_20.
This study introduces MitoBrainMap, a novel, label-free MRI framework that successfully predicts individualized mitochondrial features in the living human brain, revealing age-related declines, disease-specific alterations in mitochondrial diseases, and meaningful links to systemic physiology and cognitive performance.
This study utilizes simultaneous corticospinal resting-state fMRI and functional connectivity gradients to integrate the human spinal cord into a unified low-dimensional manifold with the sensorimotor cortex, revealing an asymmetric hierarchical organization where spinal inputs broaden cortical axes while cortical inputs preserve spinal gradients, thereby extending gradient-based mapping beyond the cortex to describe the entire neuraxis as coupled manifolds.