1432 papers
This study identifies a de novo DCLK1 variant as the causative factor of a progressive neurodevelopmental disorder by integrating cross-species functional genomics in C. elegans and patient-derived neuronal analyses to demonstrate that the mutation induces neurite defects and neurodegeneration, which can be partially rescued by wild-type DCLK1 expression or pathway targeting.
This study reveals that while protein language models encode biologically meaningful information that is linearly decodable, they lack the complex low-dimensional manifolds, multi-scale spectral structures, and hierarchical concept geometries found in single-cell foundation models, instead representing knowledge through a geometrically simple, high-linear-dimensional space shaped by the discrete and homology-driven nature of sequence data.
This study utilizes self-organizing map analysis of liver transcriptomics across diverse independent cohorts to identify five distinct, histology-independent MASLD subtypes with unique molecular and immune-stromal profiles, offering a new framework for patient stratification and targeted therapeutic strategies.
This study demonstrates that tunable polyacrylamide-alginate double-network hydrogels, particularly those crosslinked with CaCl₂, successfully replicate the nonlinear, rate-dependent transverse compressive behavior of cervical spinal cord tissue, offering a viable biomimetic surrogate for injury biomechanics and surgical simulation.
In a randomized, double-blind crossover trial involving 13 young healthy males, acute caffeine ingestion (6 mg/kg) was found to significantly impair the accuracy of low-level force output during incremental contractions compared to a placebo, suggesting it may compromise skills requiring fine force control.
This study analyzes the Tahoe-100M atlas to define an interpretable coordinate system for drug responses based on two nearly independent axes—context-robustness and dose-emergence—and identifies target transcriptional depth as a key mechanistic correlate that organizes these responses, offering a structural audit of drug mechanisms rather than a predictive model.
This study reveals that Feline morbillivirus exhibits gene-specific codon environments and a pervasive, ordered suppression of CpG dinucleotides across its coding genome, suggesting a multiscale evolutionary model where host adaptation and potential immune evasion mechanisms jointly shape viral architecture.
This study reveals that the BBSome regulates ciliary composition by functioning upstream of the ciliary gate to prevent non-ciliary proteins from being mis-loaded onto intraflagellar transport trains, thereby establishing a two-step model of cargo selection and gating.
This study reports the generation of a human scFv phage display library derived from mouse RNA to identify specific antibodies against *Pseudomonas aeruginosa* exotoxin A, aiming to develop diagnostic tools for treating infections in immunocompromised patients.
This paper describes the expansion of the AlphaFold Protein Structure Database to include 1.81 million high-confidence, proteome-scale predictions of homo- and heterodimeric complexes across 4,777 organisms, revealing novel structural topologies and conserved ancient assemblies that significantly extend beyond existing experimental coverage to facilitate functional discovery.