5802 papers
Metagenomic analysis of the rhizospheres of *Paspalum atratum* and *Paspalum notatum* reveals distinct, species-specific bacterial community compositions driven by soil pH, with *Acidobacteriaceae* dominating *P. atratum* and *Nitrosomonadaceae* characterizing *P. notatum*.
This study integrates comparative genomics and experimental phenotyping of ten *Streptococcus suis* isolates to reveal that while specific resistance genes strongly predict antimicrobial susceptibility, classical virulence markers fail to accurately rank pathogenicity, underscoring the need to combine genomic data with phenotypic assays and expand pathogenicity assessments beyond serotype 2.
This study reveals that the nutritional value of nocturnal insects for aerial predators is driven by taxonomy, adult feeding strategy, and larval habitat, but their actual ecological profitability is ultimately constrained by the predators' handling capacities and size selectivity.
This study reveals that host taxonomy and temperature differentially shape the gut microbiome assembly of six tropical moth genera across a Peruvian Andean-Amazonian elevational gradient, with microbial diversity unexpectedly increasing at higher elevations.
This study enhances industrial L-serine production in *Escherichia coli* by systematically engineering the parental strain H5 to delete re-uptake genes and optimize biosynthetic, transport, and cofactor modules, ultimately achieving a 71.84% yield increase to 0.48 g/g through strain H8-abc and medium optimization.
This study integrates machine learning, network toxicology, and molecular docking to identify six core genes (MEP1B, NAAA, PANK3, SCD, SLC23A1, and SLC6A14) as pivotal molecular targets through which perfluorooctanoic acid (PFOA) induces ulcerative colitis.
This paper presents an integrated, one-click Python pipeline that streamlines bacterial codon-usage and proteome-wide characterization by combining sequence-quality filtering, nucleotide and codon indices, and protein physicochemical properties into a single reproducible workflow, while acknowledging the need for further benchmarking to address discrepancies arising from computational definitions and reference sets.
This study demonstrates that miR-183-5p protects against hyperuricemia-induced renal interstitial fibrosis by directly targeting and downregulating Egr-1, thereby inhibiting the TGF-β1/Smad signaling pathway.
This study reveals that in land snails and slugs, duplicated Hedgehog ligand and Patched receptor genes exhibit distinct evolutionary trajectories, with Hedgehog copies undergoing relaxed constraint and rapid divergence in a specific domain, while Patched copies remain strongly conserved and syntenic, highlighting that proteome-based inventories can underestimate gene copy numbers.
This study demonstrates that DDX58 (RIG-I) knockdown in RD cells unexpectedly suppresses EV-A71 replication while inducing a transient, time-dependent activation of downstream antiviral signaling and interferon production, suggesting a complex, context-dependent regulatory role and potential compensatory immune mechanisms.