3726 papers
This study demonstrates the feasibility of a scalable, serum-free bioproduction process for the oncolytic protozoan *Neospora caninum* using industrial CHO-K1 cells and Advanced DMEM/F-12 medium, thereby addressing critical bottlenecks in standardization and regulatory compliance for its clinical translation as a cancer immunotherapy.
This computational study utilizes molecular docking, molecular dynamics simulations, and MMPBSA free energy calculations to demonstrate that the drug candidate Parecoxib exhibits strong non-bonded interactions and promising drug-likeness with the cancer-associated S100A11 protein.
This study integrates systems biology network analysis with CBMN-cyt biomonitoring to demonstrate that prenatal exposure to pesticide mixtures in an agricultural region of Colombia causes significant cytogenetic damage and genomic instability in both mothers and newborns, mediated by disruptions in oxidative stress and apoptosis pathways.
This study demonstrates that infants under one year of age can rapidly encode and consolidate detailed episodic memories during naps through sleep spindle-slow oscillation coupling, indicating that infantile amnesia stems from later memory processes rather than an inability to initially form or consolidate these memories.
This study presents the first comprehensive assessment of spider diversity in the Babor Mountains of northeastern Algeria, documenting 125 species across six habitats and identifying altitude, soil moisture, pH, and habitat type as key drivers of community structure.
Researchers developed and validated two species-agnostic MSD platform assays for detecting H5N1 antigen and antibodies in dairy cows, chickens, and humans, demonstrating their effectiveness in enhancing surveillance across diverse species and improving the identification of exposed animals.
This study demonstrates that 4T1 tumor growth and cyclophosphamide treatment induce distinct myeloid-derived suppressor cell (MDSC) populations characterized by unique subset compositions, immunosuppressive mediator profiles, and transcriptional programs, highlighting the critical impact of the induction method on MDSC phenotypes.
This study conducted a genome-wide comparative analysis of rice bean, mung bean, cowpea, and fava bean to elucidate their evolutionary relationships, gene family dynamics, and stress-adaptation mechanisms, thereby providing valuable genomic resources for the molecular breeding of climate-resilient legume crops.
This study utilizes long-read RNA sequencing to reveal that Alzheimer's disease transcriptome remodeling in the frontal cortex involves significant alterations in isoform usage, promoter switching, and splicing, implicating dysregulated transcription initiation and RNA processing beyond simple gene-level abundance changes.
This study demonstrates that a previously reported signal of adaptive DRD4 evolution in manatees is highly sensitive to taxonomic sampling and analytical robustness, ultimately failing to support a general pattern of adaptive evolution linked to the transition to aquatic environments in mammals.