🧬 Category

q-bio

1432 papers

🧬 biology

Modular magnetic recyclable dual-Escherichia coli cell factory with in situ UDP-glucose cofactor regeneration for high-efficiency green biosynthesis of isovitexin

This study presents a magnetically recyclable, modular dual-Escherichia coli cell factory co-immobilized in ternary hydrogel microspheres that achieves high-efficiency, green biosynthesis of isovitexin through autonomous in situ UDP-glucose regeneration, eliminating the need for enzyme purification and enabling repeated reuse.

Shuangqing Fu, Chao Zhang, Shuo Ma, Yujie Yuan, Wei Li, Honglei Zhang2026-07-23
🧬 biology

A quantitative FLIM-FRET framework to measure chromatin compaction with extended dynamic range and functional correlation

This study introduces a quantitative FLIM-FRET framework using Hoechst 33342 and Syto13 dyes to map chromatin compaction with extended dynamic range and concentration independence, enabling direct pixel-wise correlation between nanoscale chromatin architecture and epigenetic states in various cell models.

Simone Civita, Paolo Faraci, Alberto Leggio, Sofia Cristiani, Martina Ruglioni, Beatrice Polini, Benedetta Masciulli, Vi (…)2026-07-23
🧬 biology

Multi-omics integrative analysis of the glioma microenvironment reveals IDH-dependent cellular communication and prognostic signatures

This multi-omics study integrates single-cell RNA sequencing with advanced machine learning and hypergraph neural network analyses to construct a comprehensive IDH-dependent atlas of the glioma microenvironment, revealing distinct TAM-mediated communication pathways and establishing a robust prognostic signature with prioritized therapeutic targets for stratified treatment.

Mengnan Wang, Tianci Wu, Daming Wang2026-07-23
🧬 biology

Phytochemical Screening, Multi-Assay In Vitro Antioxidant Evaluation, GC–MS Fingerprinting, and In Silico Aromatase (CYP19A1) Docking Analysis of Psidium guajava L. Leaf Extract: Implications for Breast Cancer Chemoprevention

This study demonstrates that *Psidium guajava* leaf extract possesses significant antioxidant activity and contains phytoconstituents, particularly the triterpenoids lupeol and lupenone, which show strong *in silico* binding affinity to the aromatase enzyme, suggesting their potential as natural chemopreventive agents against breast cancer.

Manikandan Ramasamy, Nithyatharani Ramalingam2026-07-23
📄 other

Household Appliance Seals as Niches for Fungal Growth: The Role of Anthropogenic Factors and Appliance Age

This study characterizes the diverse fungal communities, including clinically significant species, inhabiting the door seals of 40 household appliances, revealing that isolation efficiency is highest at 25°C, community composition varies by appliance type, and refrigeration usage frequency inversely correlates with species richness.

Agata Piecuch, Jakub Suchodolski, Rafał Ogórek2026-07-23
🧬 biology

Excitation energy transfer between monomeric bacterioclorophylls in reaction centers of P-less mutant of purple photosynthetic bacteria

Using femtosecond spectroscopy on P-less mutant reaction centers of *Rhodobacter sphaeroides*, the study reveals rapid, temperature-dependent reversible energy transfer between monomeric bacteriochlorophylls B_A and B_B, demonstrating their strong electronic coupling within a single "supermolecule" in the absence of charge separation.

Andrei Yakovlev, Alexandra Taisova2026-07-23
🧬 biology

Quantifying Dexterity and Grip Strength Associations between Age, Cognitive Function (MoCA), and Cerebellar Gray Matter Volume in Healthy Adults across the Adult Lifespan

This study reveals a double dissociation in healthy adults where cerebellar Crus II gray matter volume independently predicts grip strength, while manual dexterity independently predicts cognitive performance, demonstrating that these motor measures map onto distinct neural and cognitive substrates rather than being interchangeable indices of aging.

Pranesh Rajesh Kannan, Raghav Pallapothu, Santosh Kudaravalli, Sriya Pallapothu, Roger D. Newman-Norlund2026-07-23
📄 other

Monosodium Glutamate Modifies Sex-Dependent Metabolic Adaptation and Hepatic Redox Vulnerability during Carbohydrate-Enriched, Lower-Protein Feeding in Wistar Rats

Chronic monosodium glutamate exposure in rats modifies sex-dependent metabolic adaptation to a carbohydrate-enriched, lower-protein diet by preserving systemic metabolic stability while progressively inducing hepatic redox vulnerability through altered antioxidant capacity and increased oxidative stress.

Joseph Chimezie, Worship Odosa Agbonifo, Hope Oluwabukola Francis, Mercy Oluwaseun Awoleye, Boluwatife Gladys Akinyemi (…)2026-07-23
🧬 biology

Autophagy-Related Alterations Associated with AMPK–mTOR Signaling in Podocyte Injury During Obstructive Cholestasis

This study demonstrates that obstructive cholestasis induces podocyte injury and glomerular damage through a dynamic dysregulation of autophagy mediated by altered AMPK–mTOR signaling, where early autophagy activation is protective but subsequent impairment exacerbates renal dysfunction.

Shuo Zhao, Xiaoyu Wang, Chao Ma, Yu Wang, Xianglong Ge, Boyu Kong, Yicong Zong, Yixiang Zhang, Lin Lyu2026-07-23