q-bio papers | Gist.Science

The Neuro-Fluid Paradigm in Microgravity: A Bibliometric Mapping of Spaceflight-Associated Neuro-Ocular Syndrome (SANS) and Intracranial Hypertension

This 2026 bibliometric analysis of 194 documents reveals that research on Spaceflight-Associated Neuro-Ocular Syndrome (SANS) has exponentially evolved from isolated ocular observations to complex models of intracranial fluid dynamics, establishing microgravity as a critical analog for terrestrial intracranial hypertension while highlighting NASA's central role in this specialized field.

Arylic Singh, Katrina Shute, Muhammed Sulman, Cameron Hawk, Cristian Mendieta2026-09-14

🧬 biology

The semantic geometry of action: convergence across foundation models, human behaviour and the brain

This study demonstrates that foundation models organize naturalistic actions within a semantic geometry that converges with human behavioral judgments and cortical representations, outperforming traditional video encoders in predicting both human similarity ratings and brain activity.

Huiguang He, Changde Du, Yi Sun, Yizhuo Lu, Shuang Qiu, Kun Zhao, Yaozhi Wen, Chen Hu2026-09-14

🧬 biology

The Critical Period Microbiota Shape Brain Plasticity

This study demonstrates that the gut microbiota is a critical regulator of experience-dependent brain plasticity, as disrupting it during early development impairs visual cortex plasticity through transcriptional changes, while transplanting juvenile microbiota into adults can restore this plasticity.

Francesca Damiani, Kousha Changizi Ashtiani, Andrea Tognozzi, Sherif Sherif Abdelkarim, Sara Cornuti, Matteo Caldarelli (…)2026-09-14

🧬 biology

Transient architecture of the embryonic pancreas determines endocrine mass

This study demonstrates that the transient lumenal plexus architecture of the embryonic pancreas actively instructs cell fate decisions through the mechanosensitive Hippo pathway regulator Merlin, which coordinates polarized membrane trafficking and restrains PI3K signaling to ensure proper lineage allocation and adult endocrine mass.

Ondine Cleaver, Neha Ahuja, Christopher Chaney, Tyler Bierschenk, Tuli Pramanik, Austin Mills, Peter Luo, Mitzy Cowdin (…)2026-09-14

🧬 biology

Proteomic identification and functional characterisation of nucleolar protein POP1 in anaplastic thyroid cancer

This study identifies the nucleolar protein POP1 as a novel oncogenic factor that is overexpressed in anaplastic thyroid cancer, where it drives tumor progression by promoting cell proliferation, cell-cycle progression, and resistance to apoptosis, thereby highlighting it as a promising therapeutic target.

Małgorzata Grzanka, Anna Stachurska-Skrodzka, Urszula Jankowska, Bozena Skupien-Rabian, Roksana Iwanicka-Nowicka, Helena (…)2026-09-14

🧬 biology

SPICE: a simulator as teacher for learning beyond native-label coverage

This paper introduces SPICE, a simulator-supervised learning framework that extends physical science model training beyond native-label coverage by using an all-atom simulator to provide online, graded feedback on learner-generated proposals, thereby enabling the discovery of valid states and the generation of confidence-weighted pseudo-labels in label-sparse environments.

Kuang Jingwen2026-09-14

🧬 biology

Apparent sequence-model contribution depends strongly on negative-set construction: a calibration across 94 ENCODE eCLIP datasets

This study demonstrates that the estimated contribution of sequence models for RNA-binding proteins varies significantly depending on the negative-set construction method and the baseline used, urging researchers to adopt cross-fitting, report composition-only performance, and avoid comparing contributions derived from different negative-set protocols.

Nirmalkumar Thirupallikrishnan Kesavan2026-09-14

🧬 biology

MA-5 attenuates disease-associated transcriptomic aging and pathological microglial states in Gaucher disease

The study demonstrates that the mitochondria-targeting compound MA-5 attenuates neuroinflammation and reverses accelerated transcriptomic aging in Gaucher disease by preserving mitochondrial integrity, suppressing cGAS–STING and NLRP3 inflammasome signaling, and improving cellular function in both mouse models and patient-derived cells.

Takaaki Abe, Yoshiyasu Tongu, Tomoko Kasahara, Kohta Nakamura, Alexander Tyshkovskiy, Yoshitsugu Oikawa, Tetsuro Matsuha (…)2026-09-14

🧬 biology

Hyperelastic Cardiovascular NN–FE: A Framework for Integrating Nonlinear Finite Element Solvers with Neural Networks for the Hyperelastic Modeling of Cardiac Valve Tissue

This paper presents a hybrid NN–FE framework that integrates a feedforward neural network with a nonlinear finite element solver to create a computationally efficient, physics-consistent surrogate model for accurately predicting the hyperelastic deformation of cardiac valve tissue under various biaxial loading conditions.

Maedeh Makki, Gerhard Holzapfel, Maziar Raissi, Chung-Hao Lee2026-09-14

🧬 biology

An undeclared free parameter underneath in vitro microelectrode array metrics

This paper demonstrates that the widely used "active-electrode count" in microelectrode array studies is not an objective measure of network maturation but rather an artifact of inconsistently applied firing-rate thresholds, urging researchers to explicitly report their criteria and conduct sensitivity analyses to ensure data interpretability.

Teertha Sri Rathod Banoth2026-09-14

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