🧬 Category

q-bio

5787 papers

🧬 biology

Accessory-genome diversity and contrasting genotype–phenotype relationships in ten porcine Streptococcus suis isolates representing five serotypes

This study integrates comparative genomics and experimental phenotyping of ten *Streptococcus suis* isolates to reveal that while specific resistance genes strongly predict antimicrobial susceptibility, classical virulence markers fail to accurately rank pathogenicity, underscoring the need to combine genomic data with phenotypic assays and expand pathogenicity assessments beyond serotype 2.

Hongqiao Lai, Hengzhi Zhu, Zenghao Xiang, Na Li, Jingze Song, Yonghong Qu, Kongwang He, Jiaqiang Niu, Libin Wen, Qi Xiao2026-10-28
🧬 biology

Host taxonomy and temperature differentially shape gut microbiome assembly in tropical moths across an Andean-Amazonian Mountain gradient

This study reveals that host taxonomy and temperature differentially shape the gut microbiome assembly of six tropical moth genera across a Peruvian Andean-Amazonian elevational gradient, with microbial diversity unexpectedly increasing at higher elevations.

Andrea Pinos, Yenny Correa-Carmona, Kim L. Holzmann, Pedro Alonso-Alonso, Andreas Brachmann, Felipe Yon, Gunnar Brehm, I (…)2026-10-28
🧬 biology

Metabolic engineering of Escherichia coli to enhance L-serine biosynthesis

This study enhances industrial L-serine production in *Escherichia coli* by systematically engineering the parental strain H5 to delete re-uptake genes and optimize biosynthetic, transport, and cofactor modules, ultimately achieving a 71.84% yield increase to 0.48 g/g through strain H8-abc and medium optimization.

Kaitai Xiao, Yamin Huang, Meijuan Xu, Guoqiang Xu, Xiaojuan Zhang, Hui Li, Jingsong Shi, Zhenghong Xu, Xiaomei Zhang2026-10-28
🧬 biology

An Integrated One-Click Python Pipeline for Bacterial Codon-Usage Analysis and Proteome-Wide Characterization

This paper presents an integrated, one-click Python pipeline that streamlines bacterial codon-usage and proteome-wide characterization by combining sequence-quality filtering, nucleotide and codon indices, and protein physicochemical properties into a single reproducible workflow, while acknowledging the need for further benchmarking to address discrepancies arising from computational definitions and reference sets.

Ujwal Dahal2026-10-28
🧬 biology

A duplicated Hedgehog ligand and a duplicated Patched receptor show different constraint and genomic context in land snails and slugs

This study reveals that in land snails and slugs, duplicated Hedgehog ligand and Patched receptor genes exhibit distinct evolutionary trajectories, with Hedgehog copies undergoing relaxed constraint and rapid divergence in a specific domain, while Patched copies remain strongly conserved and syntenic, highlighting that proteome-based inventories can underestimate gene copy numbers.

Zhi-Jie Xu2026-10-28
🧬 biology

Effects of DDX58 Gene Knockdown on EV-A71 Replication and Modulation of RIG-I–Mediated Antiviral

This study demonstrates that DDX58 (RIG-I) knockdown in RD cells unexpectedly suppresses EV-A71 replication while inducing a transient, time-dependent activation of downstream antiviral signaling and interferon production, suggesting a complex, context-dependent regulatory role and potential compensatory immune mechanisms.

Guo-E Gou, Mei Li, Meng Zhang, Xin-Yu Wang, Wen Zhang, Song Zhai, Mu-Qi Wang, Chen-Rui Liu, Ting Li, Ya-Ping Li2026-10-28
🧬 biology

Supramammillary projections to the lateral preoptic area regulate active behavior and dopamine release

This study reveals that the supramammillary nucleus-to-lateral preoptic area (SuM→LPO) pathway is a distinct circuit that, through glutamatergic signaling and dopamine release in the nucleus accumbens, promotes active behavioral responding to environmental challenges while inhibiting consummatory behaviors.

Satoshi Ikemoto, Yosuke Arima, Zengyou Ye, Coleman Calva, Xia Min, John Gibbons, Jorge Mendoza, Beyonce Getachew, Sarah (…)2026-10-28