5775 papers
This study integrates machine learning, network toxicology, and molecular docking to identify six core genes (MEP1B, NAAA, PANK3, SCD, SLC23A1, and SLC6A14) as pivotal molecular targets through which perfluorooctanoic acid (PFOA) induces ulcerative colitis.
This paper presents an integrated, one-click Python pipeline that streamlines bacterial codon-usage and proteome-wide characterization by combining sequence-quality filtering, nucleotide and codon indices, and protein physicochemical properties into a single reproducible workflow, while acknowledging the need for further benchmarking to address discrepancies arising from computational definitions and reference sets.
This study demonstrates that miR-183-5p protects against hyperuricemia-induced renal interstitial fibrosis by directly targeting and downregulating Egr-1, thereby inhibiting the TGF-β1/Smad signaling pathway.
This study reveals that in land snails and slugs, duplicated Hedgehog ligand and Patched receptor genes exhibit distinct evolutionary trajectories, with Hedgehog copies undergoing relaxed constraint and rapid divergence in a specific domain, while Patched copies remain strongly conserved and syntenic, highlighting that proteome-based inventories can underestimate gene copy numbers.
This study demonstrates that DDX58 (RIG-I) knockdown in RD cells unexpectedly suppresses EV-A71 replication while inducing a transient, time-dependent activation of downstream antiviral signaling and interferon production, suggesting a complex, context-dependent regulatory role and potential compensatory immune mechanisms.
This study reveals that the supramammillary nucleus-to-lateral preoptic area (SuM→LPO) pathway is a distinct circuit that, through glutamatergic signaling and dopamine release in the nucleus accumbens, promotes active behavioral responding to environmental challenges while inhibiting consummatory behaviors.
This study demonstrates that *Rhodopseudomonas telluris* effectively removes hydrogen sulfide from biogas through complete oxidation while simultaneously producing high-value bioproducts, including carotenoids, bacteriochlorophylls, and polyhydroxybutyrate, thereby offering a sustainable circular economy solution for biogas purification.
This study combines laboratory analysis of seed nutritional and defensive traits with a quantitative literature synthesis to demonstrate that while avian feeding preferences are positively associated with protein levels and negatively associated with phenolic compounds, the specific trade-offs between chemical defenses and physical handling resistance ultimately shape the availability of nutrient-rich seeds for granivorous birds.
This study presents an agent-based 3D model demonstrating how the interplay of electrical, mechanical, and hypoxic stresses drives non-genetic adaptation in cancer tissues, revealing that both the magnitude and temporal pattern of physical cues critically shape tumor growth dynamics, necrosis, and the accumulation of adapted cell populations.
This study demonstrates that *Schizothorax prenanti* groups maintain high-order schooling and navigate complex non-uniform flows by compressing their formation and preferring low-velocity corridors, providing critical insights for optimizing fish passage facility design to better support collective upstream migration.