3726 papers
This study introduces a novel 3D analysis method to demonstrate that honeybees execute coordinated turns by maintaining a constant total force magnitude while redirecting their body orientation, a mechanism similar to that observed in pigeons and cockatiels.
This pilot study of 14 children's play areas in Bielefeld reveals that substrate type (soil versus sand) and urbanization are the primary drivers structuring prokaryotic, fungal, and metazoan communities, with soil supporting higher diversity and all three taxonomic groups showing significant concordance in their community patterns.
This study characterizes the sesame NAC gene family through genome-wide identification, phylogenetic analysis, and regulatory profiling, revealing that sesame achieves robust stress adaptation not through gene family expansion but via a complex regulatory network involving diverse cis-elements and miRNA-mediated control.
This study demonstrates that cardiomyocyte-specific deletion of nucleolin in adult mice induces progressive heart failure characterized by myocardial remodeling, mitochondrial dysfunction, impaired energy and lipid metabolism, and the activation of a p53–P21 senescence pathway.
This study identifies a coordinated pretreatment inflammatory program, primarily driven by TNF-alpha signaling in macrophages and CDH12-positive epithelial cells, as a key predictor of neoadjuvant chemotherapy response in muscle-invasive bladder cancer through cross-cohort transcriptomic integration and single-nucleus analysis.
This study extends the Geant4-DNA framework to simulate and quantify high-LET heavy-ion-induced non-DSB clustered DNA lesions containing specific oxidative bases, providing structurally resolved damage profiles that bridge the gap between conventional strand-break analysis and mechanistic models of base excision repair.
This study utilizes multi-omics integration to define a novel immunometabolic niche in HER2-positive breast cancer where PROM1+SLC27A4+ tumor-initiating cells drive CD8A+ABCA12+ T cell exhaustion via an EGF-STAT5 axis and lignoceric acid exchange, ultimately promoting therapy resistance and metastasis.
One month after Roux-en-Y gastric bypass, the jejunal mucosa activates coordinated programs of metallothionein-driven metal homeostasis and TNF-α/NF-κB-mediated ECM remodeling, leading to increased serum trace elements and reduced systemic inflammation independent of BMI reduction.
This study developed and validated a gelatin-PVA-coated PDMS microfluidic platform that successfully supports renal cell culture under controlled laminar flow conditions, establishing a biocompatible and quantitatively defined system for future comparative drug-response studies.
This study demonstrates that a zero-cost, hybrid human-AI pipeline leveraging complementary Large Language Model architectures can effectively map the 35-year immunomodulatory evolution of *Lactobacillus rhamnosus* GG, revealing a shift from mucosal barrier focus to complex molecular signaling while overcoming the scalability crisis of biomedical literature synthesis.