1432 papers
This study reveals that while autistic and typically developing adults exhibit similar response accuracy in visual object and word recognition tasks, they display distinct and stable temporal patterns of visual processing efficiency that can reliably differentiate the two groups.
Through 3-µs molecular dynamics simulations and protein structure network analysis, this study reveals how positive and negative allosteric modulators distinctively reshape residue-level communication pathways in GLP-1R, identifying specific transmembrane routes and the hub residue R1902.60b that govern receptor activation and inhibition.
This study demonstrates that accurate and reproducible genome-wide SNP-array genotyping is feasible using ultralow quantities (as little as 50ng) of maternal plasma cell-free DNA, potentially expanding the applications of non-invasive prenatal testing despite the need for further clinical validation.
This study reveals that while *Myricaria germanica* retains historical signatures of connectivity through pollen-mediated gene flow, contemporary seed dispersal is now largely restricted within river catchments, leading to genetic isolation and highlighting the need to prioritize individual catchments as distinct conservation units to preserve the species' evolutionary potential.
This study characterizes the human Dicer1e isoform as a specialized RNase that, despite lacking canonical domains, retains catalytic activity to produce heterogeneous RNA fragments and drives context-dependent remodeling of cellular regulatory networks and proliferation, particularly in hDicer-deficient environments.
This study reveals that RORβ stability is governed by a p300-SIRT1 regulatory axis where p300-mediated acetylation at K176 primes SUMOylation at K179, thereby targeting RORβ for proteasomal degradation and modulating its transcriptional activity in neurological, retinal, and bone contexts.
This study reveals that frontotemporal lobar degeneration and Alzheimer's disease share convergent disruptions in lipid homeostasis and lysosomal metabolism, characterized by specific alterations in cardiolipins, gangliosides, and cholesterol esters alongside proteomic changes in lipid-processing enzymes, despite some subtype-specific variations.
This cross-platform Mendelian randomization study reveals that genetically proxied higher mitochondrial DNA copy number is significantly associated with lower liability to autism spectrum disorder, while finding no robust causal links to other major psychiatric disorders.
This cross-sectional study demonstrates that open-skill athletes exhibit superior inhibitory control and distinct prefrontal activation patterns in the DLPFC, OFC, and VLPFC compared to closed-skill athletes and non-athletes during the Stroop interference task.
This paper introduces Lithikos 3, a novel sample-independent volumetric morphometric approach that quantifies latent Acheulean knapping skill through a persistent scalar coefficient derived from an artefact's solid geometry, thereby extending analytical capabilities from assemblage-level tendencies to individual artefact-level distributional structures.