1432 papers
This study utilizes single-cell and bulk transcriptomic analyses to demonstrate that citrullination-related candidate biomarkers (LTF, MMP9, MMP8, IL10, LCN2, and S100A12) are primarily localized to myeloid cells and serve as indicators of neutrophil activation and monocyte/macrophage regulatory remodeling in sepsis.
This study scientifically validates the antimicrobial efficacy of Nigerian ethnobotanical plants against key oral microbes, demonstrating that methanolic extracts, particularly from neem and bitter kola, effectively inhibit microbial growth and offer potential for preventing dental caries.
This study identifies a novel form of "extra-haplotype rescue mosaicism" in Fanconi anaemia where an early post-zygotic incorporation of a second polar body creates a triploid lineage with restored DNA repair function, which is selectively expanded over the original diploid lineage in sensitive tissues like the haematopoietic system to mediate multi-lineage functional recovery.
This study demonstrates that intracellular iron compartmentalization varies across oligodendrocyte subtypes and brain regions, with dark oligodendrocytes in the cerebellar white matter exhibiting the highest mitochondrial iron levels, thereby linking iron microarchitecture to metabolic specialization.
This review advocates for integrating AI-driven epigenetic, ECG, and metabolomic clocks to overcome the limitations of single-modality aging models, thereby enabling a paradigm shift toward proactive, personalized interventions that extend healthspan and prevent cardiovascular disease.
This study demonstrates that inhaled polystyrene nanoplastic particles in rats elicit adverse pulmonary effects consistent with the poorly soluble low-toxicity (PSLT) overload paradigm at high concentrations, while lower doses induce only sub-threshold transcriptomic changes without overt toxicity.
This study demonstrates that on the Qinghai-Tibetan Plateau, ecological restoration of artificial slopes leads to significant altitudinal and spatial variations in soil physico-chemical properties and microbial community structure, driven primarily by altitude, soil depth, pH, and nutrient availability, which in turn influence the abundance of key functional genes.
This study presents a high-quality, fully phased chromosome-level genome assembly of the invasive eastern mosquitofish (*Gambusia holbrooki*) from an Australian population, generated using PacBio HiFi and Hi-C sequencing to provide a critical resource for investigating its invasion biology, local adaptation, and evolutionary genomics.
This discovery genome-wide association study in a Taiwanese cohort identifies two East Asian-specific genetic variants, one in the stress-response lncRNA LINC00251 and another in the chromatin regulator DEK, as distinct genome-wide significant markers differentiating suicidal from non-suicidal major depressive disorder.
This study demonstrates that the ethyl acetate extract of *Costus speciosus* rhizomes, particularly its active fraction 4 containing azuleno[4,5-b]furan-2(3H)-one, exhibits potent antibacterial activity against MDR and XDR bacteria through cell wall disruption and shows promising selective cytotoxicity against cancer cell lines.