5767 papers
This study demonstrates that in *Schizosaccharomyces pombe*, the Pka1 pathway promotes canavanine tolerance not by regulating amino acid uptake, but by controlling the Golgi localization of the E3 ubiquitin ligase Pub1 through the Any1-Pub1 regulatory system.
This study reveals that during polymicrobial infection, *Pseudomonas aeruginosa* secretes the pseudopaline biosynthetic product CntM to upregulate *Staphylococcus aureus* metal acquisition gene *cntA*, thereby enhancing *S. aureus* fitness and tissue burdens in a co-infection environment.
This study demonstrates that while solid-state and submerged fermentation induce distinct transcriptomic reprogramming in *Beauveria bassiana* A1, particularly affecting secondary metabolism and extracellular degradation genes, both cultivation methods ultimately yield spores with comparable insecticidal efficacy against *Plutella xylostella* at high concentrations, supporting the potential of submerged fermentation as a scalable alternative for biopesticide production.
This study demonstrates that transcutaneous auricular vagus nerve stimulation (taVNS) alleviates pain-depression comorbidity in mice by activating a specific neural pathway where serotonergic neurons in the dorsal raphe nucleus project to the central amygdala, thereby restoring serotonin transmission and modulating 5-HT1A receptors to reverse both sensory hypersensitivity and depressive-like behaviors.
This study demonstrates that placing the PS19 tauopathy mouse model on a metabolically intact C57BL/6NJ congenic background significantly delays the onset and progression of tau pathology, gliosis, and synaptic loss, thereby providing a more reliable model with greater temporal resolution for preclinical research.
This study demonstrates that a multilevel engineering strategy in *Bacillus subtilis*, involving the optimization of transcription, translation, and secretion signals, significantly enhances extracellular laccase production to achieve efficient biological delignification of tobacco straw.
This study identifies and characterizes SeAMT1;2a and SeAMT1;2b as key ammonium transporters in the halophyte *Salicornia europaea* that not only facilitate efficient nitrogen uptake under saline conditions but also independently enhance salt tolerance, likely through potassium homeostasis, highlighting their potential for phytoremediation.
This study reveals substantial heterogeneity in lignin content among decades-old *Cereus hildmannianus* somaclones, demonstrating that biochemical variation persists alongside previously documented morphological and molecular diversity in long-term ex vitro collections.
Metagenomic analysis of the rhizospheres of *Paspalum atratum* and *Paspalum notatum* reveals distinct, species-specific bacterial community compositions driven by soil pH, with *Acidobacteriaceae* dominating *P. atratum* and *Nitrosomonadaceae* characterizing *P. notatum*.
This study integrates comparative genomics and experimental phenotyping of ten *Streptococcus suis* isolates to reveal that while specific resistance genes strongly predict antimicrobial susceptibility, classical virulence markers fail to accurately rank pathogenicity, underscoring the need to combine genomic data with phenotypic assays and expand pathogenicity assessments beyond serotype 2.