5764 papers
This study demonstrates that while auxin and cytokinin exhibit partially conserved, antagonistic roles in regulating growth and development in the dryland moss *Syntrichia caninervis*, species-specific hormonal sensitivities offer promising strategies for biocrust restoration in dryland ecosystems.
This study establishes the endogenous gene *azg1* as a versatile counter-selectable marker and expands the genetic toolkit for *Trichoderma* species by enabling efficient targeted integration and engineering through CRISPR/Cas9-mediated disruption of 8-azaguanine uptake and heterologous sensitization to 5-fluorocytosine.
This study demonstrates that in a rat model of intracerebral hemorrhage, the downregulation of miR-204-5p contributes to neuronal injury by disrupting the GATA3–miR-204-5p–CAMK1/TAOK1 axis, leading to increased apoptosis and mitophagy disturbances, which can be mitigated by miR-204-5p overexpression or donepezil pretreatment.
This study utilizes buccal swabs as a proxy for ectodermal brain memory to identify distinct DNA methylation patterns in Autism Spectrum Disorder (ASD), revealing thousands of differentially methylated regions and novel candidate genes that overlap with known SFARI autism-associated genes, thereby supporting an epigenetic, embryonic-origin model for the disorder.
This study demonstrates that cell-free supernatants from *Lactobacillus* spp., particularly *L. reuteri*, effectively inhibit the growth of pathogenic yeasts *Candida glabrata* and *Cryptococcus neoformans* through organic acid production, suggesting their potential as safe and cost-effective adjuncts to conventional antifungal therapies.
This study computationally designed a multi-epitope fusion vaccine targeting Merkel cell polyomavirus proteins, which was optimized for *E. coli* expression and predicted to elicit robust immune responses through molecular docking and simulation, though further experimental validation is required.
A two-week ex situ experiment on sexually produced elkhorn coral (Acropora palmata) spats from the Dominican Republic demonstrates that while short-term survival remains high regardless of diet, heterotrophic feeding—particularly with freshly hatched Artemia—significantly enhances early post-settlement growth, suggesting that active zooplanktivory can be leveraged to improve coral restoration outcomes.
By combining computational mutagenesis with experimental validation, this study identifies specific sequence changes in the tau protein that bias its aggregation toward chronic traumatic encephalopathy (CTE)-like structures rather than Alzheimer's disease folds, thereby establishing a framework for defining sequence–structure relationships in polymorphic amyloids.
The paper presents Optimal Graph Cutting (OGC), an adaptive and extensible graph-based framework that integrates heterogeneous multi-omics data by estimating and weighting reliability at both modality and edge levels to identify clinically distinct cancer subtypes with significant survival differences.
This study demonstrates that individuals with major depressive disorder exhibit altered prefrontal late positive potential responses during neutral face processing, which are significantly associated with negative interpretation bias and indirectly linked to reduced social competence.