5763 papers
This study demonstrates that the ethanolic leaf extract of *Emilia coccinea* exhibits hepatoprotective effects against doxorubicin-induced liver injury in Wistar rats, evidenced by significantly reduced AST and ALT levels and improved liver histology compared to the untreated control group.
This study presents a modular living immunotherapeutic strategy using tumor-tropic *E. coli* engineered to surface-display adenosine deaminase and interleukin-12, which locally converts immunosuppressive adenosine into T-cell-fueling inosine while simultaneously stimulating immune responses to effectively control diverse hematologic and solid tumors.
By analyzing single-cell clones from human colorectal epithelium, this study reveals that the majority of lifelong somatic epigenetic mosaicism (~60%) originates from stable, lineage-specific epiallelic commitments established during early embryogenesis rather than from age-associated stochastic mutations, with significant functional consequences for gene expression and developmental phylogeny reconstruction.
This study identifies the zinc-finger transcription factor St18 as a critical regulator of oligodendrocyte differentiation and myelination, demonstrating its evolutionary emergence in jawed vertebrates alongside the development of myelinating oligodendrocytes and its regulation by core transcription factors like SOX10.
This study successfully established and characterized a candidate national reference strain of *Brucella melitensis* biovar 2 (ZH25) through comprehensive phenotypic, genotypic, and stability evaluations, confirming its suitability for brucellosis surveillance, vaccine development, and diagnostic applications.
The paper introduces BoNeRF-HS, a self-calibrated hyperspectral neural radiance field framework that enables high-quality, pose-free 3D reconstruction of bone and bone analogues by jointly optimizing camera intrinsics and spectral radiance while leveraging a gated spectral adapter to capture wavelength-dependent tissue details.
A study of *Acacia senegal* populations in Niger reveals that geographic distance, rather than climatic variation, is the primary driver of genetic differentiation, supporting a strong isolation-by-distance pattern.
This study demonstrates that Paeonol alleviates retinal ischemia–reperfusion injury by suppressing microglial inflammation through the inhibition of the HIF-1α/MIF signaling pathway and the subsequent modulation of MIF–CD74/CD44 communication.
This study demonstrates that while auxin and cytokinin exhibit partially conserved, antagonistic roles in regulating growth and development in the dryland moss *Syntrichia caninervis*, species-specific hormonal sensitivities offer promising strategies for biocrust restoration in dryland ecosystems.
This study establishes the endogenous gene *azg1* as a versatile counter-selectable marker and expands the genetic toolkit for *Trichoderma* species by enabling efficient targeted integration and engineering through CRISPR/Cas9-mediated disruption of 8-azaguanine uptake and heterologous sensitization to 5-fluorocytosine.