1432 papers
This paper proposes a computationally efficient, alignment-free algorithm that represents DNA sequences as 24-dimensional vectors based on the local distribution of nucleotides in strategic neighborhoods, leveraging prime factorization uniqueness to achieve linear time complexity and low memory usage for effective phylogenetic analysis.
This study reveals that PD-1 inhibits T cell activation through a dual-layered mechanism where it not only activates SHP2's phosphatase activity but also remodels SHP2 into a highly open conformation that acts as a non-catalytic biophysical barrier to dismantle TCR and CD28 signaling condensates.
This study demonstrates that early-life maternal separation in rats induces a resilient phenotype characterized by enhanced prefrontal mitochondrial bioenergetics, which protects against stress-induced negative cognitive bias in adulthood.
This study utilizes nuclear and mitochondrial genetic markers to demonstrate that Pleistocene climatic fluctuations and geological events, particularly the Andean uplift and the formation of the Isthmus of Panama, drove the historical divergence and demographic expansion of the dung beetle *Canthon cyanellus*, resulting in distinct clades in Mexico and Colombia that may include cryptic species.
This study demonstrates that increasing carbon dioxide concentrations in mice elicit distinct, non-linear patterns of brain-wide neuronal activation and physiological responses, differentiating anxiety-like states at 10% CO₂ from panic-like states at 20% CO₂ through unique behavioral, autonomic, and network-level neural signatures.
By integrating multivariate morphometrics and multilocus molecular profiling of 50 *Xiphinema* populations from the Mediterranean Basin, this study resolves species boundaries through the description of four new species, the identification of two cryptic complexes, and the expansion of available genetic resources.
This paper describes three new species of the genus *Cortinarius* (*C. umbrinatus*, *C. subochraceus*, and *C. roseolamellosus*) from mixed broadleaf forests in Uttarakhand, India, providing their morphological characteristics, illustrations, and molecular phylogenetic analyses based on nrITS sequences.
This study demonstrates that Benzo[a]pyrene exposure induces metabolic reprogramming and developmental toxicity in zebrafish embryos by linking oxidative stress to the disruption of cholesterol synthesis and vitamin D metabolism pathways.
Chronic formaldehyde inhalation in rats mimicking occupational exposure leads to region-specific neurodegeneration of parvalbumin-expressing interneurons, neuroinflammation, and cognitive-motor deficits, highlighting significant neurological risks for individuals working in anatomy dissection settings.
This paper introduces a unifying mechanical parameter based on the softness of functional coordinates relative to thermal noise to resolve biological information machines into collective modes, thereby deriving consistent thermodynamic limits for capacity and energy costs while successfully predicting empirical behaviors across ribosomes, ion pumps, and synapses.