3724 papers
This paper demonstrates that while standard survival curves cannot distinguish a process from its time reverse, a novel method using ordered absorption pulses can extract hidden Green-Kubo memory and reconstruct finite-state Markov dynamics, a capability validated through retrospective analysis of experimental optical-trap data.
The paper proposes a straightforward genotype-based model for scoring pathogenicity in ABCA4-related retinopathy that effectively predicts disease severity via age of onset, offering a conceptual framework applicable to other recessive diseases where gene copies compete for a single resource.
This study demonstrates that subject identity is a dominant source of variance in EEG spectral features that can artificially inflate machine learning performance when evaluations use standard data splits, thereby necessitating subject-wise evaluation protocols to ensure valid biomarker discovery.
This study identifies SOX17 as a critical shear-stress-induced regulator of arterial endothelial barrier integrity and resilience, demonstrating that its deficiency impairs junctional stability and promotes vascular injury through the downregulation of the downstream effector SEMA3G.
This study demonstrates that the expression of the transcript LINC03040 is reproducibly associated with increasing histological fibrosis severity in human NAFLD, supporting its potential as a stage-associated marker while highlighting the need for further validation to establish its cellular origin, causal function, and clinical utility.
This paper demonstrates that endogenous circadian oscillations can be generated by a membrane-associated post-translational feedback loop involving ion channel gating, operating independently of nuclear transcription-translation feedback loops to explain rhythmic phenomena in both anucleate red blood cells and neurons.
This pre-registered study demonstrates that while congenitally blind children exhibit a developmental lag in temporal discrimination compared to sighted peers, this deficit resolves by adulthood, supporting the inter-sensory calibration hypothesis and highlighting the need for tailored educational interventions.
This paper introduces Eigeneyes, a statistical shape model based on principal component analysis that accurately reconstructs the complete 3D geometry of the human eye from OCT scans with fewer parameters and lower error than existing methods, while enabling the generation of realistic synthetic eyes conditioned on age and axial length.
This study identifies and characterizes the kiwifruit gene *AcbHLH1* as a negative regulator of trichome density and a positive regulator of trichome length, demonstrating its potential as a genetic target for breeding low-trichome kiwifruit cultivars.
An engineered subtilisin protease (RASp) specifically targets and degrades active KRAS G12C at its switch II region, effectively suppressing downstream MEK-ERK signaling and inducing selective cell death in KRAS-dependent cancer cells while sparing non-cancerous controls.