1432 papers
This paper presents an automated AI-driven HPC pipeline that integrates distributed tomographic reconstruction with ensemble foundation models (SAM3 and DINOv3-Seg) to achieve near real-time, 20-minute scan-to-discovery segmentation of synchrotron micro-CT data, demonstrated through the analysis of grapevine xylem structures.
This study introduces an Independence-Aware Locus Audit (IALA) to demonstrate that while positional co-localization often misclassifies the genetic separability of tomato sugar and fruit weight, a rigorous, locus-by-locus analysis reveals that only two specific regions are functionally validated as independent targets, transforming the breeding challenge from a presumed physiological rule into a tractable genetic question.
This study characterizes the diversity and tissue distribution of endophytic fungi in tree peony 'Luoyang Hong', identifies *Bartalinia robillardoides* T2-07 as a potent biocontrol agent that suppresses the wheat pathogen *Gaeumannomyces graminis* var. *tritici* through a synergistic multi-mechanism involving membrane damage, antioxidant disruption, and metabolic inhibition.
This study integrates genetic diversity analysis and genome mining to demonstrate that endophytic *Alternaria alternata* isolates from diverse Iranian medicinal plants, while genetically diverse, possess a conserved and rich repertoire of biosynthetic gene clusters, highlighting their significant potential for bioprospecting novel bioactive compounds.
The study demonstrates that the short dystrophin isoform DP71, which is upregulated in DP427-deficient muscle cells, promotes early cellular adaptation and resilience by maintaining membrane-cytoskeletal homeostasis and reducing oxidative and calcium stress, thereby establishing a distinct adaptive state that mitigates but does not fully reverse the pathological effects of dystrophin loss.
This study reveals that dipeptidyl-peptidase 9 (DPP9) safeguards cells against lysosomal membrane permeabilization-induced toxicity by irreversibly degrading escaped cytosolic and nuclear cathepsins through an N-degron-mediated proteasomal pathway, thereby complementing the limited buffering capacity of endogenous cystatin inhibitors.
This study demonstrates that targeted mutagenesis of the VRS5α transcript isoform in barley genetically uncouples the pleiotropic functions of the TB1 ortholog, enabling increased tillering while preserving the two-rowed spike architecture through isoform-specific DNA binding mechanisms.
This study demonstrates that 14-3-3γ is upregulated as a protective endogenous response to CoCl₂-induced hypoxia-like stress in SH-SY5Y cells, where its knockdown exacerbates neuronal injury by intensifying oxidative stress and apoptosis.
This study overturns the classical model of paternal chromatin remodeling by demonstrating that spermatid chromatin compaction follows a programmed, pre-meiotic 3D-architecture template involving a direct histone-to-protamine-1 transition, rather than relying on the sequential replacement by transition proteins.
This study utilizes single-cell RNA sequencing to identify and validate three distinct mTOR-associated microglial populations in human mTORopathies, revealing disease-specific alterations in cell–cell communication with inhibitory neuronal circuits and shared activation states across neurodevelopmental and neurodegenerative disorders.