q-bio papers | Gist.Science

Neurocomputational mechanisms of sharing clarifying information about ambiguous news

By combining a coordination game with computational modeling and fMRI, this study reveals that the decision to share clarifying information about ambiguous news relies on a hierarchical Bayesian process where the brain integrates confidence-based beliefs about information value with social-cue-inferred beliefs about recipients' preferences, mediated by distinct neural circuits in the vmPFC, ventral striatum, TPJ, and lateral frontopolar cortex.

Jean-Claude Dreher, Valentin Guigon, Julien Benistant, Marie Villeval2026-09-15

🧬 biology

Gut Commensal Candida albicans Constrains Whole-Body Energy Storage in Mice

Persistent, non-infectious colonization of the gut by *Candida albicans* constrains whole-body energy storage and protects against diet-induced obesity in mice by remodeling the bacterial microbiome and bile acid profile to reduce lipid uptake, while simultaneously enhancing energy expenditure through coordinated metabolic and Type 17 immune responses involving $\gamma\delta$ T cells.

Marie-Claire Arrieta, Mackenzie Gutierrez, William Nguyen, Ellen Ren, Chunlong Mu, Erik van Tilburg Bernardes, Thaís Gla (…)2026-09-15

🧬 biology

Corneal deposits are placed and arrested by a surface not by protein chemistry alone

This study demonstrates that the non-renewing Bowman's layer, rather than protein chemistry alone, dictates the location, quantity, and growth arrest of corneal deposits in a genetic deposition disease, as evidenced by the distinct behavior of granular versus amyloid deposits and the formation of new deposits at surgically created interfaces.

Sejun Kim2026-09-15

🧬 biology

A locked 468-gene detoxification panel in Alzheimer's disease brain, liver, and blood: 141 high-confidence cerebral associations including lower CYP46A1 transcript abundance, and a 12-sample hepatic CYP7A1 signal

This study applies a unified 468-gene detoxification panel to reveal that Alzheimer's disease involves distinct, compartment-specific transcriptomic shifts—characterized by high-confidence cerebral down-regulation of cholesterol-disposal genes like CYP46A1 alongside metallothionein induction, a small but distinct hepatic up-regulation of CYP7A1, and a mitochondrial-dominated blood signal—demonstrating that detoxification responses do not move in unison across the brain, liver, and blood.

Mark E. McCaulley2026-09-15

🧬 biology

Mechanistic study on PSMB9 and HLA-F regulating polyamine metabolism to mediate the malignant progression of glioma

This study identifies PSMB9 as a novel oncogene and prognostic biomarker in glioma that drives malignant progression and immune evasion by upregulating HLA-F, thereby modulating polyamine metabolism and offering a potential therapeutic target.

Yan Cheng, Lin Zhang, Lina Zheng, Ting Wang, Weiwei Zhang2026-09-15

🧬 biology

Resource Depletion and Replication-Rate Optimization in Autocatalytic Lineages

This paper presents a coarse-grained mathematical framework that disentangles the distinct dynamics of finite-horizon lineage activity, thermodynamic entropy production, stochastic persistence, and competitive advantage in autocatalytic systems, revealing that optimal replication rates are finite due to resource constraints and that competitive dominance does not guarantee absolute ecological persistence.

Siddarth D Murthy2026-09-15

🧬 biology

Structural confidence and template coverage of selected proteins from Flavobacterium azizsancarii

This study evaluates the structural confidence and template coverage of 25 proteins from the Antarctic bacterium *Flavobacterium azizsancarii* using AlphaFold predictions, revealing high overall model reliability and specific functional insights for key metabolic enzymes while noting that these structural hypotheses do not yet confirm biochemical functions or environmental performance.

Cem Boyraz2026-09-15

🧬 biology

Cells are not replicates: permutation calibration of the unit-of-analysis error in a pooled sleep single-cell design (GSE137665)

This paper demonstrates that re-analyzing a pooled sleep single-cell RNA sequencing dataset (GSE137665) reveals a severe unit-of-analysis error where treating individual cells as independent replicates inflates false discovery rates to 37.7%, proving that no valid population-level inference can be drawn from such designs and highlighting the critical need to report animal-level sample sizes and use permutation calibration.

永新杨2026-09-15

🧬 biology

Differential Gene Expression of Iron Metabolism and Erythropoiesis-Related Genes in Human Erythroblasts: A Bioinformatics Analysis with Relevance to Iron Deficiency Anemia in Pakistan

This bioinformatics study analyzes gene expression data from human erythroblasts to identify significant differential expression of iron metabolism and erythropoiesis-related genes, providing molecular insights that support integrating nutritional genomics into strategies for addressing the high burden of iron deficiency anemia in Pakistan.

Namra Shams Awanᵃ2026-09-15

🧬 biology

TNF and IFN-γ converge and diverge in the molecular reprogramming of human brain microvascular endothelial cells under flow

This study reveals that under physiological flow conditions, TNF and IFN-γ induce distinct yet overlapping reprogramming in human brain microvascular endothelial cells, where TNF primarily drives leukocyte adhesion and cell cycle withdrawal while IFN-γ promotes antigen presentation, collectively suggesting that the local cytokine ratio, rather than total load, dictates the specific profile of recruited leukocytes.

Nahla Galal Metwally2026-09-15

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