1432 papers
This study identifies NDUFB2, HSP90B1, and LITAF as independent prognostic biomarkers in glioblastoma by characterizing astrocyte metabolic activation and immune microenvironment modulation through integrated single-cell and spatial transcriptomics analyses.
By leveraging aquaculture models to decouple heritability from prediction stability, this study reveals that genomic prediction accuracy in hyper-diverse genomes is governed not by the total genetic variance explained, but by the evolutionary persistence of ancient, high-frequency variants with strong linkage disequilibrium.
This study demonstrates that a benchtop 2D multi-pinhole X-ray imaging system using an energy-resolving detector can accurately quantify the intratumoral retention and biodistribution of 125I-labeled nanoparticles in mice, revealing high tumor selectivity and low off-target uptake to support preclinical optimization for nano-brachytherapy.
This study identifies serine demand as the critical factor governing the efficacy of PKM2 modulators, demonstrating that the novel compound SYX-PKM-A treats atopic dermatitis by activating PKM2 to restrict serine-dependent one-carbon metabolism in immune cells, thereby suppressing inflammation in high-serine-demand tissues like the skin.
This study demonstrates that a one-hour rest in a green space significantly reduces stress-related skin gas emissions (ammonia and allyl mercaptan) while increasing plant-derived monoterpenes in healthy individuals, suggesting that green environments modulate physiological stress responses and that skin gas analysis offers a non-invasive method for assessing such effects.
This study demonstrates that nested cross-validation significantly reduces optimism and provides more reliable performance estimates than single-split holdout or non-nested cross-validation when developing metabolomics-based predictive models for immune checkpoint inhibitor outcomes.
This metagenomic study reveals that patients with systemic sclerosis exhibit distinct gut microbial dysbiosis characterized by an enrichment of oral-associated bacteria, a depletion of butyrate-producing species, and altered metabolic pathways, which correlate with specific clinical phenotypes.
This study demonstrates that host-derived catecholamines differentially regulate bacterial growth and biofilm formation in a species-specific manner, with epinephrine and norepinephrine significantly enhancing proliferation and biofilm development in Gram-negative *E. coli* strains compared to the modest effects observed in Gram-positive *S. aureus*.
This study analyzes the genomes of 12 medically and economically significant *Pasteurellaceae* species to catalog their diverse iron uptake proteins, identifying 44 protein families and establishing a unified nomenclature system to standardize the understanding of these essential bacterial factors.
This study reveals that genome size imposes distinct ecological and physiological constraints on bryophytes and tracheophytes by differentially influencing propagule size and elemental flexibility, thereby reflecting their divergent evolutionary strategies during land colonization.