3724 papers
This study demonstrates that while both [18F]FDG PET/CT and [123I]mIBG SPECT/CT effectively monitor β3-adrenergic agonist-induced brown adipose tissue activation in mice, [18F]FDG PET/CT offers superior sensitivity for visualizing metabolic changes, whereas [123I]mIBG SPECT/CT provides complementary insights into sympathetic tissue responses.
Exposure to simulated microgravity reduces electroporation efficiency in human Jurkat cells by approximately 31% due to cytoskeletal reorganization, specifically the thickening of cortical actin, which can be partially reversed by destabilizing F-actin.
This study demonstrates that whole-genome sequencing, when integrated with targeted pathological and functional investigations, can identify elusive structural and deep intronic variants to resolve genetically undiagnosed Duchenne muscular dystrophy cases missed by conventional molecular testing.
This study of the ELSPAC cohort demonstrates that early prenatal stress independently predicts chronic low-grade inflammation and accelerated epigenetic aging in young adulthood, which in turn mediate the link between early prenatal stress and lower cognitive performance.
This study demonstrates that sex steroid hormones, particularly androgens, act as selective, cell-state-dependent modulators of metabolic and neuronal maturation programs in developing human cortical lineages, offering a potential mechanistic explanation for the male bias in autism spectrum disorder.
This paper proposes a conceptual shift in cancer biology, arguing that tumor suppressor genes are fundamentally endogenous longevity genes whose anti-cancer functions are downstream consequences of their primary evolutionary role in preserving organismal lifespan through mechanisms like growth restraint, retrotransposon suppression, and mitochondrial maintenance.
This study introduces a novel, automated framework for global marine species distribution modeling that integrates spatio-temporal barriers and spherical meshes within an INLA-SPDE approach to ensure biologically realistic connectivity, supported by a user-friendly RShiny application and validated through simulations and case studies on Atlantic cod and reef-building corals.
This cross-sectional RT-qPCR study demonstrates that TAS2R38 gene expression is uniform across various sinonasal anatomical sites in chronic rhinosinusitis patients, indicating that easily accessible tissues like the inferior turbinate are representative for molecular sampling without the need for site-specific biopsies.
This study demonstrates that the autocrine TGFβ/RhoA/ROCK1 axis in triple-negative breast cancer exhibits context-dependent rewiring, where serum deprivation reveals a consistent suppressive role of TGFβ isoforms on RhoA/ROCK1 signaling and cell survival, unlike the compensatory and enhanced clonogenic responses observed in complete media conditions.
This study presents a metabolic synergy strategy that modulates organic wastewater composition to optimize carbon flux distribution in engineered *E. coli*, significantly boosting isoprene yield and cost-efficiency while reducing carbon emissions compared to traditional waste-to-energy processes.