3724 papers
This study identifies COMMD3 as a critical regulator that coordinates the trafficking of mannose-6-phosphate receptors from early endosomes to sustain lysosomal protease maturation, thereby facilitating the cellular entry of SARS-CoV-2 and Ebola virus.
This study identifies a post-infusion metabolic shift in CAR T-cells from glycolysis to amino acid-driven oxidative phosphorylation as a critical determinant of efficacy, revealing that amino acid depletion in patients limits T-cell function and demonstrating that engineering CAR T-cells to overexpress specific amino acid transporters (SLC1A5, SLC7A1, SLC38A9) enhances their persistence and anti-leukemic activity.
This retrospective multicenter study demonstrates that an AI-derived quantitative morphological analysis of blastocysts outperforms conventional manual consensus grading in both agreement with expert assessments and the prediction of fetal heart tone.
This paper presents a reproducible, StarDist-based deep learning framework implemented in QuPath that enables high-throughput, automated segmentation and morphometric analysis of *Drosophila* salivary gland secretory granules, offering superior accuracy and sensitivity compared to conventional methods while preserving biological validity.
This paper introduces the BCAT-LIF framework, which combines top-down context-adaptive somatic integration timescales with intrinsic bursting dynamics to significantly enhance the robustness and learning performance of dendritic spiking neural networks on streaming tasks under temporal distribution shifts.
This study characterizes *Penicillium janthinellum* Z1-1031 as a multifunctional plant-associated fungus that promotes *Panax notoginseng* growth and health through antifungal, antioxidant-enhancing, and metal-biosorption activities, largely mediated by its secondary metabolite Brefeldin A.
This study reveals that an ALMS1 variant causes primary endocardial fibroelastosis by disrupting proximal centriole organization and downregulating THY1, which together drive a myofibroblast-like phenotype that can be therapeutically targeted via THY1 modulation.
This study demonstrates that a nanofiber gelatin bone graft matrix possesses favorable physicochemical properties, excellent biocompatibility, and effective bone regenerative performance comparable to a predicate device, supporting its potential as a safe and effective scaffold for bone tissue engineering.
This study demonstrates that while immature oocytes can develop into blastocysts after short-term in vitro insemination, the resulting embryos frequently exhibit maternal alloploidy due to asynchronous nuclear maturation rather than polyspermia, as confirmed by quantitative parental contamination testing and FISH analysis.
Green-synthesized zinc oxide nanoparticles derived from *Azadirachta indica* exhibit potent anticancer activity against MDA-MB-231 breast cancer cells by inducing cytotoxicity, cell cycle arrest, and apoptosis through the upregulation of Caspase-3 and p53, thereby inhibiting cell migration and proliferation.