3724 papers
By analyzing medium-density SNP data from 357 European dark honey bees, this study demonstrates that integrating admixture, inbreeding, and individual genetic contribution estimates into high-resolution network visualizations provides a robust framework for monitoring fine-scale population structure and guiding the conservation of *Apis mellifera mellifera*.
This study demonstrates that single-cell RNA sequencing-guided apoptotic-mimetic mineralized nanovesicles delivering siPLIN2 effectively reprogram CD36-enriched macrophages to alleviate lipotoxic inflammation and promote neurovascularized bone repair in diabetic mice.
This study identifies the transcription factor E4F1 as a selective regulator of the proteasome catalytic β1 subunit (PSMB6), revealing a novel layer of proteasome homeostasis where individual catalytic subunits are controlled by distinct transcription factors.
Phylogenomic analysis of four pandemic *Klebsiella pneumoniae* lineages reveals that while human-to-animal transmission is the predominant direction, specific ST11 strains have successfully moved from animals back into human populations, highlighting the need for integrated genomic surveillance to detect such cross-species spillover events.
This study identifies a distinct pattern of reduced functional connectivity across multiple brain networks, particularly involving the default mode network, in drug-naïve depressed patients with high trait impulsivity, suggesting that impulsivity-based subtyping can help parse depression heterogeneity and guide personalized interventions.
This study establishes OTUD6B as an essential deubiquitinase for mammalian cardiac development, demonstrating that its deficiency causes congenital heart defects and perinatal lethality by impairing cardiomyocyte cell-cycle progression and ventricular chamber formation.
RAD-SEN-REGEN proposes a translational framework for human spaceflight that addresses the continuum of biological stress by investigating regenerative resilience through DNA damage, cellular senescence, and mitochondrial dysfunction, while utilizing mesenchymal stromal cells, MUSE cells, and extracellular vesicles as research platforms to distinguish scientific rigor from premature therapeutic claims.
This paper demonstrates that history-driven attention is a distinct mechanism shaped by learned perceptual regularities rather than semantic ones, operating implicitly and persistently in contrast to the transient dynamics of stimulus-driven selection and the qualitative differences of goal-driven selection.
This study concludes that a 17-gene transcriptomic proxy for mitoxyperilysis lacks construct validity as a measure of senescence, prognosis, or drug sensitivity in colorectal cancer and aging, as it failed to meet predefined validation criteria across multiple independent datasets and analyses.
This study identifies *Candidatus* Syntrophoarchaeum caldarium as the first archaeon capable of anaerobically oxidizing propane in syntrophy with a sulfate-reducing bacterium, elucidating the specific enzymatic mechanisms and metabolic pathways involved in this process.