5759 papers
This study demonstrates that SHED-derived exosomes attenuate Alzheimer's disease pathology and functional excitotoxicity in patient-derived 2D and 3D cerebral organoid models by delivering therapeutic miRNAs that modulate tau hyperphosphorylation and amyloid processing, thereby validating their potential as a multi-target biological therapy for dementia.
The paper introduces the Shaped Priority Account, a neural-dynamical model demonstrating that diverse and seemingly contradictory behavioral signatures of visual attention can emerge from a single underlying mechanism, challenging the assumption that distinct effects require distinct cognitive processes.
This study utilizes comparative proteomics to reveal that while *Mycobacterium tuberculosis* and *M. bovis* share conserved hypoxic adaptation strategies centered on lipid metabolism and the DosRST regulon, *M. bovis* exhibits distinct species-specific responses characterized by a broader upregulation of stress-related proteins and unique remodeling of nitrogen metabolism.
This study utilizes integrated chloroplast and nuclear genomic data to reveal that Japanese *Cinnamomum* species in the Nansei Islands comprise two distinct evolutionary lineages shaped by deep-sea barriers and long-term isolation, with one lineage diverging from Southeast Asian ancestors and another closely related to Taiwanese species.
By integrating single-cell transcriptomic data to map cell fate energy landscapes, this study reveals that the PIN1-p53 axis acts as a critical bifurcation node where its distinct topological regulation drives Alzheimer's disease toward neurodegeneration and glioblastoma toward uncontrolled proliferation, thereby mechanistically explaining their inverse comorbidity.
This study provides the first cross-species causal evidence that the age-dependent gene FREM3 is essential for maintaining brain volume and cognitive function, demonstrating that its loss in mice leads to accelerated brain atrophy and cognitive decline, while reduced genetically regulated expression in humans similarly correlates with smaller brain surface area and poorer cognitive performance.
This study demonstrates that in a DNCB-induced mouse model of allergic dermatitis, the localization of overexpressed HSPA1A dictates its impact on skin pathology, with extracellular accumulation promoting faster inflammation resolution and attenuated hyperplasia, while intracellular accumulation leads to persistent inflammation and pronounced tissue remodeling.
This study elucidates the genetic architecture of Aleutian disease resilience in mink through genome-wide association studies identifying significant SNPs and genes, while comparing prediction methods to show that single-step genomic BLUP (ssGBLUP) offers the highest accuracy for immune response and feed variation traits, suggesting its future potential as the optimal approach for genomic selection in the industry.
This study characterizes a rare de novo KRAS p.Val14Ile variant in Noonan syndrome by demonstrating its distinct clinical profile with reduced lymphatic and hematological abnormalities compared to other KRAS variants, and elucidating its pathogenic mechanism through molecular dynamics simulations that reveal altered GTP binding and conformational dynamics.
This study identifies StCCR6 as a critical regulator that enhances potato resistance against *Ralstonia solanacearum* by coordinating lignin biosynthesis for cell wall reinforcement and boosting antioxidant enzyme activity to mitigate oxidative stress.