PIN1-p53 bifurcation dictates opposite cell fate decisions in Alzheimer’s disease and glioblastoma via distinct energy landscape topologies
By integrating single-cell transcriptomic data to map cell fate energy landscapes, this study reveals that the PIN1-p53 axis acts as a critical bifurcation node where its distinct topological regulation drives Alzheimer's disease toward neurodegeneration and glioblastoma toward uncontrolled proliferation, thereby mechanistically explaining their inverse comorbidity.
Original paper licensed under CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/). This is an AI-generated explanation of a preprint that has not been peer-reviewed. It is not medical advice. Do not make health decisions based on this content. Read full disclaimer
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