5759 papers
This paper investigates a fractional-order model of breast cancer dynamics involving tumor cells, CTLs, and CAR-T cells, revealing that the system exhibits relaxation oscillations with a distinct frequency-comb spectral structure whose spacing is modulated by specific immune and tumor parameters.
This study employs an integrative systems biology framework to demonstrate that pulmonary tuberculosis and Alzheimer's disease share reproducible neuroimmune co-expression programmes and a 12-gene biomarker signature, revealing conserved transcriptional mechanisms linking chronic infection to neurodegeneration.
This study introduces PolarTIL, a novel TIL therapy generated via Type-17 cytokine polarization that enhances antitumor memory and efficacy in cutaneous malignancies, while unexpectedly revealing that TGF-β1 is an essential, rather than inhibitory, regulator for programming these therapeutic responses.
This study reveals that the circumsporozoite surface protein gene (pmcsp) in recently emerged Vietnamese Plasmodium malariae isolates exhibits substantial genetic diversity, particularly within its central repeat region, suggesting that global P. malariae diversity is greater than previously recognized and highlighting the need for broader global sampling to fully understand the parasite's evolutionary dynamics.
The paper introduces TileBac, a dual-dose annotated cryo-EM dataset of *Pantoea* sp. YR343 featuring low-dose membrane tiles and higher-dose bacterial/flagella images with frame-level data, designed to advance segmentation, registration, and dose-dependent analysis methods for large-area cryo-EM.
This study demonstrates that Aβ42 oligomers induce neurotoxicity in differentiated SH-SY5Y cells by increasing cellular stiffness and activating Piezo1 channels, which triggers sustained calcium overload leading to mitochondrial dysfunction, cytoskeletal remodeling, and caspase-4-mediated pyroptosis.
This study presents the first continent-wide phylogenomic analysis of African hantaviruses using all three coding genomic segments, revealing strong host-associated and geographic structuring while establishing a foundational framework for future surveillance and evolutionary research across the continent.
This study of healthy young adults across 34 countries reveals that human gut resistome burden and composition are distinct yet complementary features influenced by divergent climatic, geographic, and taxonomic factors, demonstrating that high antimicrobial resistance can coexist with beneficial microbial taxa and underscoring the need for integrated profiling in One Health surveillance.
This study identifies that age-related cortical bone loss is driven by ATPIF1-mediated metabolic remodeling in osteoclasts, which enhances glycolytic ATP production and α-ketoglutarate accumulation to sustain cell survival and resorptive function, thereby revealing the ATPIF1–IDH3A axis as a potential therapeutic target for osteoporosis.
This paper extends the classical stochastic SIS model to networks with dynamic node activity, demonstrating that while activity rates do not alter the epidemic threshold or stationary infection levels, they significantly slow down transient dynamics by allowing temporarily disabled infected nodes to act as a reservoir that sustains the infection.