3724 papers
This fNIRS study demonstrates that experienced orienteers outperform novices in spatial maze tasks by exhibiting enhanced and more focused activation in the dorsolateral and ventrolateral prefrontal cortex, indicating that long-term orienteering training optimizes prefrontal neural efficiency to improve spatial cognition and decision-making.
This study demonstrates that resistance to age-related hearing loss in C57BL/6J mice is conferred by a broad MSM/Ms-derived centromeric region on chromosome 12 extending beyond the single *ahl10* locus, while also revealing that females exhibit earlier hearing loss progression than males across all tested genetic backgrounds.
This cross-sectional study of young male basketball players reveals that drop jump kinematics undergo significant age-related adaptations between 13 and 16 years, characterized by a shift from knee-dominant to ankle-dominant mechanics that enhance plyometric performance, as identified through linear regression and machine learning analysis.
This paper proposes and validates novel composite and adaptive ensemble learning methods for integrating disease and pharmacogenomics GWAS data to overcome existing limitations in polygenic risk score development, thereby significantly improving drug response prediction and patient stratification in precision medicine.
This study reveals that intermanual transfer during de novo motor skill acquisition is asymmetric, favoring practice with the non-dominant hand followed by the dominant hand, and is driven by individual variations in the intrinsic functional organization of the sensorimotor network.
This study reveals that the *Peganum harmala* microbiome is hierarchically structured by strong compartmental filtering and exhibits distinct temporal dynamics, where a stable bacterial core persists across seasons despite soil-driven recruitment and contrasting fungal diversity trends.
This pilot study validates the Human Organotypic Skin Explant Culture (hOSEC) as a viable, cost-effective ex vivo alternative to animal models for evaluating *Staphylococcus aureus* colonization, infection dynamics, and antibiotic efficacy while preserving human skin structural and immune integrity.
This study demonstrates that closely related *Bacillus subtilis* strains (HM01 and HM04) elicit distinct, crop-specific growth promotion in chickpea and maize, respectively, driven by unique accessory genomic traits and differential restructuring of the rhizosphere microbiome.
This study demonstrates that PRDX4 alleviates ovarian aging by suppressing endoplasmic reticulum stress-mediated ferroptosis in granulosa cells, thereby reducing cellular senescence and highlighting 4-PBA as a potential therapeutic agent for female reproductive longevity.
This study demonstrates that glycyrrhizic acid suppresses bladder cancer progression and sensitizes tumor cells to cisplatin by inhibiting the NF-κB and PI3K/AKT signaling pathways, as validated through integrated network pharmacology and experimental assays.