1432 papers
This study demonstrates that patients with alcohol use disorder exhibit significantly reduced circulating levels of the perineuronal net components brevican and neurocan, which correlate with disease severity and chronicity, suggesting these proteoglycans serve as peripheral biomarkers of alcohol-induced neuroplastic disruption.
This study employs computational metabolomics to demonstrate that, beyond the traditionally emphasized diterpenoids, distinct flavonoid structural patterns serve as key drivers of species-specific chemical identity in the medicinal plants *Plectranthus hadiensis* and *Plectranthus ambiguus*.
This study reveals that metastatic cancer cells hijack vagal sensory neurons by utilizing the protein NINJ1 to activate a β-catenin-dependent repair program, thereby enhancing their ability to colonize distant tissues and identifying NINJ1 inhibition as a promising therapeutic strategy to block metastatic outgrowth.
In a controlled human infection study of 48 immune-experienced participants, higher pre-inoculation levels of nasal IgG antibodies against the SARS-CoV-2 spike protein, particularly the receptor-binding domain, were strongly associated with protection against viral shedding.
This paper introduces CoralEye, a decentralized, edge-optimized computer vision framework using a quantized MobileNetV2 model to achieve real-time, 97% accurate thermal stress diagnostics on consumer-grade hardware, thereby addressing the critical delay in manual coral reef monitoring and enabling proactive conservation in bandwidth-constrained regions.
This study demonstrates that streptozotocin-induced hyperglycemia upregulates and promotes the colocalization of Pax6 and Tgf-β1 in the mouse heart, suggesting that this interaction drives fibroblast-to-myofibroblast differentiation and contributes to diabetic cardiac dysfunction.
This study validated six susceptibility loci (UBE2U, CDKN2A, SIRT1, NAV2, ST8SIA2, and TP53) in German uranium miners, demonstrating that radon exposure significantly modifies lung cancer risk through gene-environment interactions, while also identifying a potential arsenic interaction for SOX5.
This study utilizes proteomic analysis to demonstrate that outer membrane vesicles (OMVs) from both toxigenic and nontoxigenic *Bacteroides fragilis* strains induce distinct yet overlapping molecular responses in intestinal cell lines, including cytoskeletal reorganization and immune modulation, suggesting that while both strains contribute to anti-inflammatory effects, the presence of toxins in the toxigenic strain may temporarily delay this response until cellular damage is repaired.
Following a focal M1 lesion in macaques, motor recovery is driven by a large-scale network reorganization characterized by an anterior-to-posterior rewiring of the fronto-parietal circuit, where weakened canonical PMv–AIP connections are compensated by reinforced non-canonical PMv–pVIP pathways to restore grasping function.
This study reveals that *Vibrio vulnificus* strains in the Baltic Sea, comprising a mix of environmental and clinical isolates, have adapted to the cold, brackish environment through positive selection on specific genes like *opsX* and *menC*, while undergoing a genomic trade-off characterized by a drastic reduction in defense system complexity and increased mobile genetic element integration to facilitate human infection.