3724 papers
This study identifies MXRA5 as a hypoxia-induced driver of extracellular matrix remodeling and immunosuppression in lung adenocarcinoma via the PI3K-AKT pathway, linking its overexpression to poor prognosis and resistance to immunotherapy.
This paper introduces an Adaptive Quantum Approximate Optimization Algorithm (QAOA) that utilizes gradient-driven operator selection to dynamically construct problem-specific circuits, demonstrating superior precision, specificity, and hardware efficiency over fixed-architecture variants for genomic sequence classification under realistic NISQ noise constraints.
This exploratory study demonstrates that transcranial temporal interference stimulation (tTIS) can non-invasively target deep prefrontal circuits to differentially modulate memory control mechanisms, with focal dACC stimulation potentially enhancing retrieval-induced forgetting and dispersed prefrontal stimulation accelerating the decay of facilitated memories, thereby validating tTIS as a promising tool for investigating deep-brain contributions to human memory.
This study utilizes RNA-seq data to reveal that alternative polyadenylation serves as a critical, dose-dependent regulatory mechanism in rice under cadmium stress, orchestrating tissue-specific and temporal gene expression changes in photosynthesis, stress response, and protein synthesis through the modulation of poly(A) site selection and miRNA-mediated transcript stability.
This study reveals that the gnathodiaphyseal dysplasia-associated gain-of-function mutations G503E and R582I activate TMEM16E through distinct structural mechanisms—disrupting the TM3–TM4 interface and remodeling an extracellular loop network, respectively—despite their similar functional phenotypes.
This study, grounded in the "One Health" concept, analyzed 2,236 samples from China's dairy production chain to reveal that *Staphylococcus aureus*, particularly multidrug-resistant ST59 clones, originates primarily from bovine carriage and spreads through contaminated milking equipment and poor worker hygiene, posing a significant transmission risk to consumers.
This study demonstrates that the immune-related long non-coding RNAs Morrbid and NeST are significantly upregulated in the peripheral blood mononuclear cells of COVID-19 patients compared to healthy controls, suggesting their potential as biomarkers for the host immune response to SARS-CoV-2 infection.
The paper introduces CustomGWAS, a standardized end-to-end framework that unifies diverse GWAS steps into a single reproducible environment, ensuring methodological consistency and statistical accuracy comparable to established tools like PLINK and GEMMA while significantly enhancing the transparency and comparability of genomic analyses.
While healthy older adults exhibit lower baseline working memory usage than younger adults, they retain the adaptive flexibility to increase usage and reduce memory failures when environmental demands rise, suggesting that modifying task conditions can effectively support everyday memory in aging.
This paper introduces HA-DMF, a hybrid deep matrix factorization framework that integrates molecular embeddings, miRNA-derived regulatory features, and directional attention mechanisms to achieve state-of-the-art performance in predicting drug combination synergy by modeling task-specific latent interactions within cellular contexts.