5759 papers
This study reveals that a Golgi-based quality control system triages mislocalized membrane proteins to prevent lipid metabolism deregulation and the lethal accumulation of diacylglycerol-enriched compartments, demonstrating that the resulting lipid imbalance, rather than the proteostasis defect itself, is the primary cause of cellular collapse.
This study utilized a multi-locus 3VmrMLM algorithm to analyze a diverse rice panel across multiple years, identifying stable and environment-dependent genetic loci along with prioritized candidate genes that govern grain shape and weight, thereby providing valuable resources for marker-assisted and environment-aware breeding.
This study identifies a nutrient-sensitive O-GlcNAc modification on RIPK1 at Ser331 as a critical metabolic checkpoint that couples glucose availability to the inhibition of necroptosis, thereby maintaining tissue homeostasis and offering a therapeutic target for severe drug-induced skin eruptions like SJS/TEN.
This study resolves the cryo-EM structures of comammox *Nitrospira inopinata* ammonia monooxygenase (NiAMO) in both inhibitor-free and allylthiourea-bound states, revealing a unique methyl-plastoquinol-coupled catalytic mechanism and inhibitor-responsive architecture that clarifies the molecular basis for its distinct nitrification efficiency and susceptibility to inhibitors.
This study demonstrates that macrophage-specific deletion of the H2-Ab1 gene ameliorates spinal cord injury by inhibiting M1 polarization and foamy macrophage formation, thereby reducing inflammatory cytokine secretion, ROS accumulation, and neuronal apoptosis.
This study reveals that edematous severe acute malnutrition is driven by a coordinated epigenetic "scar" characterized by the targeted hypomethylation of protocadherin and innate immune sensor genes, which unifies the molecular mechanisms behind the disease's concurrent epithelial barrier breakdown, systemic inflammation, and neurodevelopmental deficits.
This study demonstrates an in vitro proof-of-concept for generating clonally selected, hypoimmune limbal stem cells via CRISPR-Cas9 gene editing and CD47 overexpression, which successfully evade allogeneic immune rejection while maintaining stem cell identity and expandability, thereby paving the way for a scalable, off-the-shelf therapy for limbal stem cell deficiency.
This paper reports the identification and characterization of Coleus blumei viroid 8 (CbVd-8), a novel infectious coleviroid found in coleus plants that features a unique terminal conserved hairpin and forms a distinct phylogenetic clade despite sharing a central region with CbVd-5.
This study demonstrates that nano-hydroxyapatite-modified platelet-rich fibrin (HA-PRF), particularly when conditioned for three days, significantly accelerates the in vitro wound closure of gingiva-derived mesenchymal stem cells compared to standard and titanium-prepared PRF, suggesting its potential to enhance early regenerative outcomes in oral and periodontal healing.
This study demonstrates that dopamine receptor D2 (Drd2) signaling in CD4⁺ T cells is essential for maintaining the differentiation, stability, and suppressive function of regulatory T cells, thereby preventing gut inflammation and mitigating dopaminergic neurodegeneration in Parkinson's disease.