🧬 Category

q-bio

1432 papers

📄 other

Cell-resolved cortical architecture and intercellular communication distinguish bipolar and major depressive disorders

This study utilizes a large-scale, harmonized single-nucleus transcriptomic resource of the dorsolateral prefrontal cortex to demonstrate that while Major Depressive Disorder involves broad transcriptomic dysregulation and vascular-associated glial alterations, Bipolar Disorder is characterized by a distinct oligodendroglial signature and attenuated neuronal communication, revealing divergent cellular architectures that could inform future biological stratification of mood disorders.

Laura Orsolini, Matteo Giulietti, Giulio Longo, Francesco Piva, Umberto Volpe2026-07-27
📄 other

In vivo cortical neuron-astroglial functional coupling strengthens with acute stress but is impaired by chronic stress in mice

Using dual-color in vivo fiber photometry in mice, this study reveals that while acute and repeated stress strengthen cortical neuron-astroglial functional coupling as an adaptive mechanism, chronic stress reverses this trajectory by sensitizing neuronal reactivity while blunting astroglial responses, leading to impaired coupling that coincides with the onset of depression-like behavioral deficits.

Mounira Banasr, Yashika Bansal, Sierra Codeluppi-Arrowsmith, Jaime Knoch, Yuliya Nikolova, Etienne Sibille2026-07-27
📄 other

Targeting penicillin binding protein 2a in methicillin resistant Staphylococcus aureus using selected phytocompounds: an environmental surveillance and in silico molecular docking study

This study detected methicillin-resistant *Staphylococcus aureus* carrying the *mecA* gene in household harvested rainwater in Nigeria and utilized in silico molecular docking to identify epigallocatechin gallate, luteolin, andrographolide, and apigenin as promising phytocompounds for targeting the PBP2a protein, though these findings require further experimental validation.

Benson Okorie, Blessing Awoyemi, Emeka Okorie, Ukamaka Okpor, Tracy Osatohan, Promise Ogungbemi, Akin Oyewumi, Richmore (…)2026-07-27
📄 other

Unravelling the mechanisms of cyanobacterial resilience in photosynthetic living materials

This study reveals that entrapping *Synechocystis* sp. PCC 6803 in calcium-alginate hydrogels induces a coordinated, maintenance-oriented physiological state characterized by proteome remodeling toward stress protection and resource reallocation, which preserves photosynthetic activity and enables long-term resilience in photosynthetic living materials.

Henna Mustila, Elia Marelli, Sergey Kosourov, Yagut Allahverdiyeva-Rinne2026-07-27
📄 other

Pan-genome analysis reveals structural variation and breeding-group divergence of the glutathione S-transferase gene family in highbush blueberry (Vaccinium corymbosum L.)

This study presents a pan-genome analysis of 23 highbush blueberry cultivars revealing that the glutathione S-transferase (GST) gene family exhibits an open pan-genome structure with significant structural variation and breeding-group divergence, ultimately identifying three Phi-class GSTs as the most credible candidates for regulating anthocyanin accumulation and fruit pigmentation.

Bin Li, Qingping Yi, Kairun Xie, Ruiyi Fan2026-07-27
📄 other

An organ-on-chip model of vulvovaginal candidiasis to study the interplay between fungal pathogenicity and inflammation

This study presents a novel vulvovaginal candidiasis-on-chip model that successfully simulates the recruitment of neutrophils to Candida albicans-infected vaginal epithelium, enabling the investigation of the inflammatory mechanisms driving disease progression and serving as a platform for evaluating new therapies.

Kar On Cheng, Victoria E. Gross, Zoltán Cseresnyés, Mariia Kolchanova, Özlem Pullin, Ezgi Gürel, Luca Figge, Teresa Zela (…)2026-07-27
📄 other

Genomic features of mecA-harboring Staphylococcus epidermidis infecting an illegally traded rufous-bellied thrush (T. rufiventris)

This study reports the isolation and genomic characterization of a multidrug-resistant, methicillin-resistant *Staphylococcus epidermidis* Sequence Type 280 from a skin lesion in an illegally traded rufous-bellied thrush, highlighting the role of urbanization and wildlife trade in the spread of antibiotic resistance within a One Health framework.

Bianca Alvarenga Anti Pompeu, Gabriel Siqueira dos Santos, Ticiana Zwarg, Mayra Hespanhol Frediani, Amanda Haisi, João P (…)2026-07-27
📄 other

Spatial heterogeneity and interfacial signaling hub function of CPTCs across the ventral body wall continuum

This study reveals that Cd34+ Pdgfra+ Telocytes (CPTCs) exhibit spatial heterogeneity across the ventral body wall, with superficial fascia-resident CPTCs functioning as a dynamic interfacial signaling hub that integrates skin and muscle compartments via Wnt and Nectin pathways to coordinate cross-layer communication.

Yumeng Guo, Zhenwei Zhang, Yeping Shi, Jianming Yue, Haixiang Huang, Lu Mei, Meng Dai, Mingyu Bi, Dong Hou, Qiusheng Che (…)2026-07-27
📄 other

Inflammation-Associated Neuronal and Astrocytic Ensembles in the Dorsal Bed Nucleus of the Stria Terminalis Modulate Peripheral Immune Response via the Brain-Spleen Axis

This study identifies the dorsal bed nucleus of the stria terminalis (dBNST) as a critical forebrain hub where inflammation-activated neuronal ensembles and ATP-driven astrocytic signaling coordinate to modulate peripheral immune responses via a brain-spleen axis.

Xijia Xin, Yaqi Tang, Mengdong Shi, Weikai Han, Xi Xu, Chenyu Zhang, Tongtong Meng, Qingwei Yue, E Liu, Jinhao Sun2026-07-27
🧬 biology

Polysaccharide Extracted From the Fibrous Residue of the Pseudofruit of Anacardium Occidentale as a Promising Biomaterial for Scaffold Development

This study demonstrates that a polysaccharide extracted from the fibrous waste of the *Anacardium occidentale* pseudofruit possesses favorable physicochemical, biological, and structural properties, establishing it as a promising, sustainable biomaterial for developing biocompatible scaffolds.

Maria Crisnanda Almeida Marques, Livio Cesar Cunha Nunes, Ezequiel da Silva Ferreira, Edmilson Araújo de Oliveira Junior (…)2026-07-27