5759 papers
This study demonstrates that Stathmin 2 (STMN2) promotes osteogenic differentiation and bone regeneration in mouse bone marrow mesenchymal stem cells by activating the Wnt signaling pathway, suggesting its potential as a therapeutic target for bone repair.
This study presents the first chromosome-scale genome assemblies for two Black Bengal Goat individuals, generated using PacBio HiFi sequencing and RNA-seq-based annotation, providing a high-quality reference resource to support future comparative genomics, breeding, and conservation efforts for this economically important South Asian breed.
This paper introduces EV-PROTEOMICS, a database-driven computational framework that utilizes a subtractive refinement strategy to significantly enhance the clarity and mechanistic relevance of extracellular vesicle-associated protein profiles for identifying genotoxic and carcinogenic signatures.
By integrating bulk and single-cell transcriptomic data with machine learning and experimental validation, this study identifies PPWD1 and TMEM50B as key upregulated genes in the protein secretion pathway of osteoporosis, linking them to proteostasis dysregulation and bone marrow mesenchymal stem cell alterations.
This exploratory analysis of nearly 800,000 software mentions in biomedical papers reveals that sentence-level citation marking is generally low (10.7%) and varies significantly by tool type, with statistical packages being cited least frequently, highlighting the need for targeted policy interventions and improved validation methods.
This study reports the first isolation of a highly protease-producing *Alishewanella aestuarii* strain (B11) from sacred grove soils in North Gujarat, India, which was identified and optimized to yield significantly enhanced enzyme activity suitable for industrial applications.
This study integrates sialylation and amino acid metabolism signatures to develop a six-gene prognostic model for colorectal cancer that stratifies patients by risk, reveals distinct immune-metabolic tumor microenvironments, and identifies PLOD3 as a critical driver of tumor progression and a potential therapeutic target.
This study demonstrates that cholesterol-based supramolecular complexes incorporating redox-active CeO₂₋ₓ nanoparticles and menadione significantly enhance the anticancer efficacy of pharmacological ascorbic acid by inducing severe redox imbalance and cell death in fibrosarcoma and metastatic bladder cancer cells, outperforming GdYVO₄:Eu³⁺ nanoparticles due to superior ROS generation capabilities.
This study utilizes mitochondrial sequence analysis to reclassify the phylogenetic position of *Oncomelania lorelindoensis*, elevate *O. minima* to a new family (Mewengkangiidae), and consolidate several *Oncomelania* subspecies under *O. nosophora*, thereby resolving key taxonomic ambiguities within the genus.
This study demonstrates that diet-induced metabolic dysfunction in pre-diabetic Sprague–Dawley rats triggers early cognitive impairment and hippocampal neurodegenerative changes, including increased amyloid and tau levels, before the onset of overt type 2 diabetes.