3724 papers
This study reveals that in a mouse model of Parkinsonism, males exhibit greater nigrostriatal degeneration while females display distinct motor cortical glutamatergic remodeling characterized by reduced VGLUT2 expression, highlighting critical sex-specific differences in disease mechanisms and potential therapeutic targets.
This study demonstrates that isoliensinine inhibits gastric cancer progression by inducing mitochondrial apoptosis and G1-phase cell cycle arrest, while synergizing with cuproptosis inducers through FDX1 targeting to amplify DLAT aggregation and oxidative stress, offering a promising combinatorial therapeutic strategy.
This study demonstrates that during naturalistic visual search, higher decision confidence is reliably associated with reduced theta and alpha band power in late search and pre-decision intervals, identifying extended pre-response EEG dynamics that offer a promising temporal window for future brain-computer interface applications.
This study identifies two novel begomovirus species, Chilli leaf curl Dindigul virus and Chilli leaf curl Karur virus, alongside established strains, as the causative agents of severe chilli leaf curl disease epidemics in southern India, revealing extensive recombination events and strong purifying selection that drive the rapid evolution of these viral complexes.
GeneResolver is a traceable, privacy-oriented hybrid multi-agent pipeline that improves rare-disease diagnosis by first classifying case etiology to route evidence appropriately, thereby outperforming existing tools in both phenotype-only and combined phenotype-genomic benchmarks.
MDD-Explorer is a multi-scale visual analytics framework that integrates unsupervised state-transition modeling with interactive visualizations to help clinicians identify and interpret dynamic functional connectivity patterns associated with Major Depressive Disorder in large-scale fMRI datasets.
This pilot study utilized Next-Generation Sequencing of neonatal meconium to demonstrate that lower microbial diversity and specific compositional shifts, such as altered *Diaphorobacter*/*Clostridioides* ratios, are associated with the subsequent development of food allergies in a two-year follow-up.
This study demonstrates that the loss of the epigenetic regulator SETDB1 in mouse embryonic stem cells triggers cell death and pluripotency loss by dysregulating translation-related pathways and significantly altering the expression of a network of high-confidence autism-associated genes.
A resurvey of grassland plant communities in a fragmented Japanese landscape over a decade reveals that significant species loss and community disassembly are driven by both recent habitat destruction and historical landscape changes persisting as an extinction debt, with these lagged effects varying by spatial scale and plant functional group, underscoring the need for proactive restoration alongside habitat conservation.
This study demonstrates that in vivo base editing can effectively rescue hearing in a humanized mouse model of DFNB111 even after cochlear maturation, provided that Deiters' cell architecture remains intact, thereby establishing structural integrity rather than chronological age as the critical determinant of the therapeutic window.