3724 papers
This study demonstrates that IFN-λ protects H1N1-infected BEAS-2B cells from virus-induced death by regulating the c-Fos/c-Jun signaling pathway, thereby elucidating a molecular mechanism for potential IFN-λ-based therapies against respiratory viral infections.
This study demonstrates that the pectin lattice of the streptophyte alga *Penium margaritaceum* exhibits adaptable topography influenced by calcium levels and light-driven carbon availability, revealing dynamic recovery mechanisms and banding patterns that serve as a model for understanding plant cell wall dynamics.
This study identifies a novel six-gene polyamine metabolism-related prognostic signature for colorectal cancer that stratifies patient risk and reveals a distinct malignant epithelial subpopulation driving immune evasion, DNA repair, and stemness at the single-cell level.
This study demonstrates that while sEMG-informed knee-angle prediction improves numerical accuracy (RMSE), this improvement does not linearly correlate with reduced simulated instability, as the relationship between error and stability inverts below a threshold of approximately 13°, indicating that lower RMSE values do not universally guarantee more stable motion in the tested regime.
Despite demonstrating excellent stability in human plasma, the immuno-PET radioligand [68Ga]Ga-NOTA-GZP undergoes rapid in vivo metabolism in mice, leading to significant degradation and distinct biodistribution patterns that necessitate cautious interpretation of imaging data and improved chelation strategies.
This study reveals that inflammation in Crohn's disease imposes distinct evolutionary selection pressures on *Phocaeicola vulgatus* phages, causing a loss of genetic diversity in tailed phages and a shift in diversification patterns for filamentous phages, thereby highlighting the complex dynamics between phages, bacteria, and the human host in health and disease.
Using molecular dynamics simulations on an improved E. coli membrane model, this study reveals that calcium cations promote more stable DNA adsorption with less membrane reorganization than magnesium cations, while also demonstrating that DNA can act as a plug within electroporation-induced pores.
This eye-tracking study reveals that children with ADHD exhibit distinct facial region-specific attention patterns during emotional face viewing, characterized by quicker attention to the mouth and prolonged focus on the nose, rather than a generalized avoidance of the eye region.
This study reveals that mechanical stress-induced activation of the Piezo1 ion channel in lung epithelial cells triggers the release of ADAM protease-dependent inflammatory factors, which subsequently activate endothelial cells to promote leukocyte transmigration across the alveolar-capillary barrier.
This study analyzes 20 African *Salmonella enterica* genomes to reveal that multidrug resistance is driven by a complex interplay of regional phylogenetic history, horizontal gene transfer, and the co-selection of antibiotic resistance by environmental biocides and heavy metals, necessitating a unified One Health approach for mitigation.