🧬 Category

q-bio

1422 papers

📄 other

Organoid research in diabetes and cardiovascular diseases: bibliometric mapping of knowledge evolution and emerging frontiers in organ-on-a-chip systems, bioprinting, artificial intelligence, and multi-omics

This bibliometric analysis of 802 publications from 2016 to 2025 maps the rapid evolution of organoid and organ-on-a-chip research in diabetes and cardiovascular diseases, highlighting a paradigm shift toward high-fidelity disease modeling driven by the integration of bioprinting, single-cell omics, and artificial intelligence.

Chao Fu, Chunlin Li, Yuxin Li, Xiangyang Gao, Bingqing Han, Hao Zhang, Shanshan Liu, Fei Wang, Qiang Zeng2026-07-27
📄 other

Phytochemical Screening, GC-MS Analysis, Antioxidant, Cytotoxicity, and Anti- Inflammatory Studies of Medicinal Plant Persicaria glabra Growing in Bangladesh

This study demonstrates that *Persicaria glabra* (Lal Kukri), a medicinal plant from Bangladesh, contains diverse phytochemicals and exhibits significant antioxidant, cytotoxic, and anti-inflammatory activities in its various solvent extracts, thereby validating its potential as a source of therapeutic compounds.

Nazmul Hasan, Md. Farid Uddin, Koushik Saha2026-07-27
📄 other

Characterization of urinary microbiome dysbiosis in prostate cancer and benign prostatic hyperplasia: A metagenomics study from North-Eastern Algeria

This metagenomics study from North-Eastern Algeria characterizes distinct urinary microbiome dysbiosis in prostate cancer and benign prostatic hyperplasia patients compared to controls, identifying specific microbial signatures and demonstrating how chemotherapy further disrupts this ecosystem, thereby suggesting the urinary microbiome as a promising non-invasive biomarker and therapeutic target for prostate diseases.

Amel Amel Abderahim, Florian Salipante, Nassima Djahmi, Mohamed Lahlou Redjdal, Malik Atoui, Karim Atoui, El Mahdi Bacco (…)2026-07-27
📄 other

Cell-resolved cortical architecture and intercellular communication distinguish bipolar and major depressive disorders

This study utilizes a large-scale, harmonized single-nucleus transcriptomic resource of the dorsolateral prefrontal cortex to demonstrate that while Major Depressive Disorder involves broad transcriptomic dysregulation and vascular-associated glial alterations, Bipolar Disorder is characterized by a distinct oligodendroglial signature and attenuated neuronal communication, revealing divergent cellular architectures that could inform future biological stratification of mood disorders.

Laura Orsolini, Matteo Giulietti, Giulio Longo, Francesco Piva, Umberto Volpe2026-07-27
📄 other

In vivo cortical neuron-astroglial functional coupling strengthens with acute stress but is impaired by chronic stress in mice

Using dual-color in vivo fiber photometry in mice, this study reveals that while acute and repeated stress strengthen cortical neuron-astroglial functional coupling as an adaptive mechanism, chronic stress reverses this trajectory by sensitizing neuronal reactivity while blunting astroglial responses, leading to impaired coupling that coincides with the onset of depression-like behavioral deficits.

Mounira Banasr, Yashika Bansal, Sierra Codeluppi-Arrowsmith, Jaime Knoch, Yuliya Nikolova, Etienne Sibille2026-07-27
📄 other

Targeting penicillin binding protein 2a in methicillin resistant Staphylococcus aureus using selected phytocompounds: an environmental surveillance and in silico molecular docking study

This study detected methicillin-resistant *Staphylococcus aureus* carrying the *mecA* gene in household harvested rainwater in Nigeria and utilized in silico molecular docking to identify epigallocatechin gallate, luteolin, andrographolide, and apigenin as promising phytocompounds for targeting the PBP2a protein, though these findings require further experimental validation.

Benson Okorie, Blessing Awoyemi, Emeka Okorie, Ukamaka Okpor, Tracy Osatohan, Promise Ogungbemi, Akin Oyewumi, Richmore (…)2026-07-27
📄 other

Unravelling the mechanisms of cyanobacterial resilience in photosynthetic living materials

This study reveals that entrapping *Synechocystis* sp. PCC 6803 in calcium-alginate hydrogels induces a coordinated, maintenance-oriented physiological state characterized by proteome remodeling toward stress protection and resource reallocation, which preserves photosynthetic activity and enables long-term resilience in photosynthetic living materials.

Henna Mustila, Elia Marelli, Sergey Kosourov, Yagut Allahverdiyeva-Rinne2026-07-27
📄 other

Pan-genome analysis reveals structural variation and breeding-group divergence of the glutathione S-transferase gene family in highbush blueberry (Vaccinium corymbosum L.)

This study presents a pan-genome analysis of 23 highbush blueberry cultivars revealing that the glutathione S-transferase (GST) gene family exhibits an open pan-genome structure with significant structural variation and breeding-group divergence, ultimately identifying three Phi-class GSTs as the most credible candidates for regulating anthocyanin accumulation and fruit pigmentation.

Bin Li, Qingping Yi, Kairun Xie, Ruiyi Fan2026-07-27
📄 other

An organ-on-chip model of vulvovaginal candidiasis to study the interplay between fungal pathogenicity and inflammation

This study presents a novel vulvovaginal candidiasis-on-chip model that successfully simulates the recruitment of neutrophils to Candida albicans-infected vaginal epithelium, enabling the investigation of the inflammatory mechanisms driving disease progression and serving as a platform for evaluating new therapies.

Kar On Cheng, Victoria E. Gross, Zoltán Cseresnyés, Mariia Kolchanova, Özlem Pullin, Ezgi Gürel, Luca Figge, Teresa Zela (…)2026-07-27