🧬 Category

q-bio

5759 papers

🧬 biology

A study of particle behaviour in dynamic extracellular environments using nanoparticles as model nanoscale probes

This study utilizes a label-free optical caustics-based microscopy technique to demonstrate that the dynamic extracellular environment of human mesenchymal stem cells significantly alters the transport behavior of gold nanoparticles, highlighting the critical influence of local biological conditions such as serum exposure, surface charge, and protein content on nanoscale mobility.

Genevieve Schleyer, Eann A. Patterson, Judith M. Curran2026-10-30
🧬 biology

Integrated RNA-seq and ATAC-seq profiling for assessing chemically induced inflammatory responses in human TK6 cells

This study demonstrates that integrating RNA-seq and ATAC-seq profiling in human TK6 cells reveals that the non-genotoxic tumor promoter TPA induces sustained, coordinated transcriptional and chromatin remodeling responses, particularly in inflammatory genes, which persist and evolve even after chemical removal, offering a refined molecular framework for assessing chemically induced inflammatory effects.

Keigo Yamakita, Manabu Yasui, Masamitsu Honma, Kei-ichi Sugiyama, Ryoji Fujiki, Atsushi Kaneda, Kiyoe Ura, Akira Sassa2026-10-30
🧬 biology

Panel-Gene Transcriptomic Associations in Amyotrophic Lateral Sclerosis: a donor-resolved seven-cohort analysis of a locked 468-gene detoxification panel

This study presents a donor-resolved meta-analysis of seven ALS cohorts using a locked 468-gene detoxification panel, identifying 28 high-confidence differentially expressed genes—including ABCA1, APOE, and AQP1—that remain robust across sensitivity analyses and refine previous findings by correcting for tissue heterogeneity and replicate counting errors.

Mark E. McCaulley2026-10-30
🧬 biology

Activity Fragmentation and Posture-Transition Structure in Adults Aged 70-95 Years: A Participant-Level Analysis of HAR70+

This study analyzes 18 adults aged 70–95 to demonstrate that movement amount, bout continuity, and state-transition organization capture distinct properties of activity patterns, supporting the need to explicitly report temporal organization in wearable measurement studies while acknowledging that these specific protocol-bound results do not yet reflect habitual behavior or clinical meaning.

weijian zhao2026-10-30
🧬 biology

PATZ1 Restrains Basal-like Breast Cancer Aggressiveness while Preserving FOXA1-Driven Luminal Identity

This study identifies PATZ1 as a critical regulator of breast cancer subtype identity that maintains luminal differentiation and suppresses basal-like aggressiveness by directly activating FOXA1, while its loss or microenvironmental suppression drives phenotypic plasticity and tumor progression.

Sabrina Battista, Michela Vitiello, Maria Pia Albanese, Cristina Quintavalle, Tina Di Palma, Mariastella Zannini, Gerola (…)2026-10-30
🧬 biology

Reference choice affects positional enrichment of AlphaGenome variant rankings at APOL1-MYH9

This study demonstrates that the choice of chromatin-accessibility reference set significantly influences the interpretation of AlphaGenome variant rankings at the APOL1-MYH9 locus, revealing strong podocyte-specific enrichment that varies depending on the reference used, while cautioning that these findings do not yet confirm tissue-specific variant-effect accuracy or generalizability.

Christopher Lawrence2026-10-30
🧬 biology

Integrative transcriptome and metabolome analysis identifies flavonoid biosynthesis as well as ascorbate and aldarate metabolism driving natural cold tolerance variation in dormant peach (Prunus persica)

This study integrates transcriptomic and metabolomic analyses to reveal that while cold stress universally activates MAPK and hormone signaling pathways in dormant peach, genotypic divergence in cold tolerance is primarily driven by constitutive differences in flavonoid biosynthesis and ascorbate-aldate metabolism, specifically involving the downregulation of L-ascorbate oxidase genes and upregulation of L-ascorbic acid-2-glucoside in cold-tolerant cultivars.

Zhendong Tian, Jie Li, Qihang Tian, Zhaoyuan Wang, Yu Wang, Guojian Liu, Ruifeng Chang, Yonghong Li2026-10-30
🧬 biology

Identification of shared blood transcriptomic features and candidate sedative targets in chronic insomnia with comorbid anxiety: an in-silico study

This in-silico study identifies a shared peripheral blood transcriptomic signature linking chronic insomnia and generalized anxiety disorder, highlighting immune dysregulation and the complement receptor C3AR1 as a potential bridge to sedative pharmacology, while emphasizing the need for further experimental validation.

Weixian Xie, Wenyue Xiang, Zhiming Huang2026-10-30
🧬 biology

Ultra-weak photon emission as a dual-axis probe of dynamized water: physicochemical characterization and germination bioassay

This study demonstrates that water processed by a Biodynamizer® device exhibits a 27.5-fold increase in ultra-weak photon emission compared to tap water and induces a corresponding 4.3-fold increase in photon emission from germinating alfalfa seedlings, establishing a robust observational baseline for future mechanistic research into the bioactivity of dynamized water.

Luis Saluden, Olivier Salières, Everyne Van De Kraats, Christophe Carrette2026-10-30
🧬 biology

Mouse spatial transcriptomics implicates the thalamus and cortex in autism and schizophrenia

Using a novel spatial transcriptomics dataset and statistical method on adult mouse brains, this study reveals that genes associated with autism and schizophrenia are most enriched in the thalamus, followed by the cortex and hippocampus, thereby highlighting the thalamus as a major player in these neuropsychiatric disorders.

David M. Young, Ruchira Sharma, Narjes Rohani, Chimmi Dema, Lindsay Liang, Bernie Devlin, Devanand S. Manoli, Stephan J. (…)2026-10-30