5759 papers
This study demonstrates that ACOT11 acts as a tumor suppressor in prostate cancer by inhibiting disease progression through the disruption of mitochondrial homeostasis and the suppression of the PI3K/AKT signaling pathway, suggesting its potential as a biomarker and therapeutic target for castration-resistant prostate cancer.
This paper demonstrates that while a cryptochrome radical pair functions as a readable quantum reservoir with measurable information capacity, it offers no quantum advantage over classical networks and is constrained by chemical turnover rates rather than spin coherence lifetimes, leading to a new, experimentally testable criterion for biological quantum computation.
In West African rice agroecosystems, trophic differentiation among three sympatric pipistrelle-like bat species is modest and primarily driven by seasonal reorganization of dietary overlap rather than stable interspecific segregation, as species shift their shared resource use patterns significantly between the wet and dry seasons.
This study demonstrates that ethanol extracts of *Baliospermum solanifolium*, particularly the 80% concentration, exhibit significant antibacterial activity against *Staphylococcus aureus* and *Bacillus subtilis* as well as cytotoxic effects against human cancer cell lines, likely due to their high phenolic and flavonoid content.
This study comprehensively characterizes the tomato GLP gene family and functionally validates that SlGLP11-1 acts as a positive regulator of disease resistance against *Botrytis cinerea* by mediating ROS homeostasis through the promotion of H₂O₂ accumulation.
This study demonstrates that three clinically distinct *Acinetobacter baumannii* strains (LS01, AB5075, and XH386) exhibit significant heterogeneity in acute lethality, surface-associated phenotypes, and stress responses despite sharing major pathogenicity and stress-associated genomic systems, with strain-specific differences driven by condition-dependent transcriptional remodeling rather than the mere presence or absence of key functional pathways.
This Mendelian randomization study utilizing sc-eQTL data from 14 immune cell types identifies elevated CFL1 gene expression, particularly in CD8NC cells, as a genetically predicted protective factor against subarachnoid hemorrhage risk, highlighting its potential as a therapeutic target.
This study demonstrates that Nr2f1 haploinsufficiency, a cause of Bosch-Boonstra-Schaaf optic atrophy syndrome, impairs short-term spatial memory in mice by disrupting dentate gyrus inhibitory circuits through reduced parvalbumin interneuron density and altered GABAergic signaling, leading to an excitatory/inhibitory imbalance.
This study establishes a standardized dual-staining framework using MTT and iodine to reliably detect and classify distinct cell death phenotypes in the model microalga *Dunaliella salina*, validating its ecological relevance and proposing an international consortium to unify mortality diagnostics for improving global carbon cycle models.
This study reveals that the gut microbiota-derived metabolite indole-3-lactic acid (ILA), produced by *Lactobacillus murinus*, protects against renal ischemia-reperfusion injury by activating the aryl hydrocarbon receptor (AhR) to suppress NOX2-mediated oxidative stress and lipid peroxidation.