3724 papers
This study identifies rosalexins as a novel branch of the maize diterpenoid defense network, elucidating how gene duplication and functional divergence created a unique biosynthetic pathway where epoxidation by ZmCYP71Z18 is critical for antifungal activity, thereby expanding the plant's modular chemical immunity.
This study demonstrates that while *Klebsiella pneumoniae* isolates colonizing preoperative cardiac surgery patients share clonal backgrounds with those causing invasive infections, the latter are significantly enriched for hypervirulent features, particularly the ST23-K1 clone and the *rmpA2* regulator, suggesting that high-risk colonizing clones may evolve into severe infections.
This study utilizes temporal proteomic and phosphoproteomic profiling to demonstrate that lung adenocarcinoma-derived malignant pleural effusions, specifically via tumor-derived extracellular vesicles, rapidly induce profound immune suppression and cell death in peripheral immune cells by hijacking intracellular kinase signaling pathways.
The marine bacterium *Providencia rustigianii* PMRU2.7, isolated from the alga *Chaetomorpha linum*, effectively bioremediates diverse azo dyes through coordinated enzymatic cleavage, significantly reducing their phytotoxicity and residual toxicity.
This study demonstrates that soursop (Annona muricata) treatment significantly attenuates diabetes-induced cerebellar neurodegeneration and motor dysfunction in Wistar rats by improving glycemic control, reducing oxidative stress and apoptosis, and restoring neurotransmitter levels and cerebellar histology.
This study demonstrates that the Tibetan endemic fish *Schizopygopsis younghusbandi* exhibits a narrow reproductive thermal window where 16°C optimally supports the HPGL axis and ovarian development, while temperatures exceeding 20°C disrupt reproductive regulation through oxidative stress, lipid metabolic dysregulation, and impaired steroidogenesis.
This study demonstrates that deficiencies in Bardet-Biedl syndrome BBSome subunits (BBS1 and BBS4) disrupt receptor endocytosis and autophagy flux to differentially dysregulate TGF-β signaling, thereby promoting epithelial-to-mesenchymal transition (EMT) and highlighting subunit-specific mechanisms in retinal degeneration.
This paper demonstrates that population structure significantly influences the continuation probability threshold required for Tit-for-Tat to dominate Always Defect in the Iterated Prisoner's Dilemma, with scale-free networks generally requiring higher thresholds than regular or small-world networks, while specific structural features like clustering and hub placement further modulate these cooperation dynamics.
This study demonstrates that fusing the RIG-I 2CARD domain to Ebola virus-like particles creates a potent, self-adjuvanting vaccine platform that elicits robust, long-lasting antibody responses and provides complete protection against lethal Ebola virus challenge in mice with a single dose, while also serving as a versatile system for incorporating other antigens.
Short-term severe time-restricted feeding combined with sucrose access induces pancreatic islet remodeling in mice while preserving glycemic homeostasis and endocrine function.