3724 papers
This study identifies and functionally characterizes a novel homozygous deep intronic PADI6 variant that activates a cryptic splice site, leading to a truncated protein and recurrent early embryonic arrest, thereby expanding the known genetic causes of female infertility.
This study identifies EtMob1 as a critical regulator of *Eimeria tenella* sporogony and demonstrates that generating an EtMob1-deficient strain via CRISPR/Cas9 and IAA-inducible degradation effectively attenuates pathogenicity while inducing protective immunity, establishing it as a promising candidate for a safer live vaccine against avian coccidiosis.
This study integrates Mendelian randomization, bulk, and single-cell transcriptomic analyses to identify four ferroptosis-related genes (AKR1C2, MAPK3, MAP3K11, and CDKN1A) as genetically protective factors in colorectal cancer that are downregulated in tumors and linked to critical tumor microenvironment remodeling, including immune infiltration, endothelial transition, and intercellular communication.
This study reveals that METTL1 promotes ribosome biogenesis and tumor progression through a novel methyltransferase-independent mechanism by recruiting NAT10 to enhance ac4C modification and stabilize CCDC86 mRNA.
This study reveals that the Haryana Jaat population possesses a unique tripartite maternal genetic structure dominated by South Asian lineages with significant West Eurasian contributions and a distinctive 7.65% East Eurasian ancestry (primarily haplogroup D) that sets them apart from neighboring groups like the Ror, Gujjar, and Kamboj.
This study combines in silico screening and in vitro assays to demonstrate that specific substituted tryptamines, particularly benzotript, can interact with tubulin near the colchicine binding site and modulate microtubule polymerization dynamics in a compound- and concentration-dependent manner.
This study utilized GNSS technology to quantify external match demands and variability in elite men's canoe polo, revealing that playmakers cover greater distances and reach higher speeds than air players, thereby supporting the need for evidence-informed, role-specific training.
This paper presents a systematic benchmark of eleven rare-cell detection methods using large-scale downsampling datasets, identifying aKNNO and RareQ as top performers while offering practical guidance on how cell abundance, transcriptional separability, and computational efficiency influence detection outcomes.
This study demonstrates that overexpressing the transcription factor CrRAP2.2 in citrus reprograms defense-related transcriptional networks to enhance vascular cell wall reinforcement through lignin deposition, thereby establishing a mechanistic link between this factor and resistance against *Xylella fastidiosa*.
This study demonstrates that black tea volatile fractions (BTVs) alleviate alcohol-induced intestinal stress in rats by remodeling the gut microbiota to drive tryptophan metabolism toward NAD⁺ biosynthesis, thereby restoring mitochondrial function and suppressing pyroptosis to preserve gut barrier integrity.