q-bio papers | Gist.Science

Global Carriage of Antimicrobial Resistance Genes and Virulence Factors Among Physicians in Cirrhosis Care

A global metagenomic study of physicians caring for cirrhosis patients reveals that while those from low- and middle-income countries harbor greater antimicrobial resistance gene diversity, they generally carry a low prevalence of clinically relevant resistance genes and virulence factors compared to their patients, suggesting physicians are unlikely to be primary reservoirs for drug-resistant pathogens.

Andrew J Sommer, Masoumeh Sikaroodi, Andrew Fagan, Brian C Davis, Alexander Khoruts, Patrick M Gillevet, Jasmohan S Baja (…)2026-11-01

🧬 biology

Clinical phenotypes, bone-age delay, and exploratory coding-variant architecture in idiopathic short stature: a single-center integrative analysis

This single-center, hypothesis-generating study integrates clinical and genetic data to link the severity of idiopathic short stature with bone-age delay and lower IGF-1 levels, while nominating chromatin-remodeling genes as potential candidates for future investigation in larger cohorts.

Lijun Hao, Yifan Yang, Biyao Lian, Wenxin Feng, Chunyan Yin, Yuesheng Liu2026-11-01

🧬 biology

Whole Genome Sequence (WGS) of Bordetella pertussis Strains in Amhara Regional State, Ethiopia

This study utilized whole genome sequencing of Bordetella pertussis strains from the Amhara Regional State, Ethiopia, to identify the predominance of ptxP1 alleles while detecting emerging ptxP3 strains, suggesting a potential genotype shift that warrants further investigation into its relationship with vaccine types.

Solomon Taye Sima, Debasu Damtie, Belay Tessema, Baye Gelaw, Feleke Moges2026-11-01

🧬 biology

Senescence-associated KRAS upregulation in peripheral T cells links to premature coronary artery disease

This study identifies senescence-associated upregulation of KRAS in cytotoxic CD8+ T cells as a molecular link between immunosenescence and premature coronary artery disease, highlighting it as a potential biomarker and therapeutic target.

Zhao Sun, Ziyu Yang, Xuedong Wang, Meng Zhang, Rui Gao, Mengyue Yang, Yanchao Li, Qi Liu, Jingbo Hou2026-11-01

🧬 biology

Ancestry-enriched and shared polygenic signals associated with high IQ in a Japanese extreme-phenotype cohort

This study identifies a genome-wide significant ancestry-enriched variant in the *PPP2R1A* gene and demonstrates shared polygenic signals between Japanese and European populations in a case-control GWAS of individuals with exceptionally high IQ (≥140).

Jun Kawasaki, Shun Nogawa, Kazuki Tainaka2026-11-01

🧬 biology

Model Rankings in Drug–Target Affinity Prediction Vary Across Evaluation Regimes: A Controlled Multi-Seed Study of Model-Comparison Reliability

This study demonstrates that rankings of drug–target affinity prediction models vary significantly across different evaluation regimes (such as cold-target versus cold-drug settings) and random seeds, arguing that reliable model selection requires scenario-matched, multi-seed, and auditable comparison protocols.

Haobo Kui, Xinyuan Cui2026-11-01

🧬 biology

TNF-α Induces CCL28-Mediated Recruitment of Th22 Cells in Hepatocellular Carcinoma

This study elucidates that TNF-α promotes the recruitment of Th22 cells in hepatocellular carcinoma by activating the NF-κB pathway to upregulate CCR10 expression, thereby facilitating CCL28-mediated chemotaxis and establishing a positive feedback loop within the tumor immune microenvironment.

Jingsong Huang, Yilin Li, Qing Yang, Lan Huang, Fan Ding, Qiang Tian, Shenzong Rao, Yanqiong Rao2026-11-01

🧬 biology

miR-195-3p alleviates atherosclerosis by regulating VSMC functions through JNK2/NF-κB pathway

This study demonstrates that miR-195-3p alleviates atherosclerosis by directly targeting JNK2 to inhibit the NF-κB inflammatory cascade, thereby suppressing pathological vascular smooth muscle cell dysfunction and reducing plaque burden.

Pan Hou, Tongwei Lv, Qing Lu, Xianxian Zhao, Shifang Ding2026-11-01

🧬 biology

Pregnancy, childbirth and caregiving alter functional connectivity in response to infant faces

This fMRI study reveals that pregnancy, childbirth, and caregiving enhance functional connectivity between brain networks involved in face perception, social cognition, memory, and reward processing when mothers view infant faces, with the strongest neural responses observed when viewing their own nurtured infants.

Kenji Hishikawa, Yoshihiro Nakano2026-11-01

🧬 biology

APH-1A and CDK5 Expression Correlates with Tau Hyperphosphorylation and Its Attenuation by Brahmi and Donep-M in STZ induced Alzheimer’s Disease Model

This study validates APH-1A and CDK5 as Alzheimer's disease biomarkers linked to tau hyperphosphorylation in an STZ-induced neuronal model and demonstrates that both Brahmi and Donep-M effectively attenuate these pathological changes.

Umesh Prasad Sah Hathi, Abhishek Kumar, Jyotsna Arora, Suneel Kateriya2026-10-31

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