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5759 papers

🧬 biology

Predictive Threshold Modeling of Evolutionary Plasticity and Colony Collapse Risk in Apis Mellifera Through Climate-Driven Architectural Degradation, BehavioralEnergetics, And Material Economy Using YOLO-Seg, and Sentinel-3 Framework

This study integrates YOLOv11-seg, Sentinel-3 satellite data, and 3D material analysis to establish a predictive threshold model demonstrating that climate-induced thermal fluctuations degrade honeycomb symmetry in *Apis mellifera*, with a critical symmetry coefficient of 0.6214 signaling a 70% risk of colony collapse and revealing greater resilience in Boreal populations compared to Mediterranean ones.

MRK Pathan2026-11-01
🧬 biology

Identification of Non-Invasive Tumor-specific Biomarkers for Hepatocellular Carcinoma through Multi-transcriptomics Data Integration

This study integrates multi-transcriptomic data from TCGA and GEO to identify a novel panel of non-invasive blood-based biomarkers, including specific plasma genes, PBMC genes, and exosomal miRNAs, for the early detection of hepatocellular carcinoma.

Zahra Golshan, Hanieh Fadakar, Saeedeh Salehi, Yasaman Najafi, Sanaz Akbari, Maryam Momeni, Alieh Gholaminejad2026-11-01
🧬 biology

Single-Cell Genomic Profiling Identifies an H3F3B–SEPTIN6 Axis Associated with Malignant Epithelial Phenotypes in Lung Adenocarcinoma

This study utilizes single-cell genomic profiling and experimental validation to demonstrate that the upregulation of H3F3B drives malignant epithelial phenotypes in lung adenocarcinoma by promoting proliferation, migration, and invasion through a positive regulatory axis with SEPTIN6.

Xianghua Zhou, Liqin Wu, Fanfan Yang, Chunxiao Hou, Jiaqi Wang2026-11-01
🧬 biology

Bacterial dysbiosis in sinonasal fungal ball: a paired 16S rRNA gene sequencing study

This paired 16S rRNA gene sequencing study reveals that sinonasal fungal balls are characterized by significant local bacterial dysbiosis on the affected side, featuring reduced diversity, distinct taxonomic and functional shifts, and altered community networks compared to healthy contralateral sinuses.

Pengyu Shi, Yi Wang, Yuan Zhang, Ting Yang, Jie Zhou, Yun Zeng, Shouxiang Dong, Yunchuan Li, Hongzheng Wei2026-11-01
🧬 biology

Characterization of Plasmodium infections and genetic diversity of Plasmodium malariae msp-1 among asymptomatic individuals in southern Benin

This study reveals a significant burden of asymptomatic and sub-microscopic *Plasmodium* infections, including *P. malariae*, in southern Benin that are frequently missed by conventional diagnostics, while characterizing the gene's relatively limited genetic diversity through *msp-1* sequencing.

Romuald Agonhossou, Romaric Akoton, Simon Rothbauer, Mbencho Macqueen Ngum, Victorine M. Ndiwago, Thirumalaisamy P. Vela (…)2026-11-01
🧬 biology

Sex-specific Cognitive Effects of Environmentally Relevant Microplastic Exposure in the Western Mosquitofish

This study reveals that environmentally relevant polyethylene terephthalate microfiber exposure selectively impairs cognitive performance in a sex-specific manner in western mosquitofish, suppressing natural cognitive differences between males and females without affecting their behavior or body condition.

Maxximus Ramsaroop, Jingping Graber, Adrienne Lihou, Liyuan Gong, Rivers Hartzell, Yang Lin, Molly Cummings2026-11-01
🧬 biology

First-Year Infections Requiring Penicillin and Gut Bacterial Features at One Year: A Secondary Analysis of the Public ABIS Birth Cohort Dataset

This secondary analysis of the ABIS birth cohort found that a higher burden of first-year infections requiring penicillin was associated with lower levels of three specific gut bacterial features at one year, though the primary significant finding was not independent of prior reports and does not support changing prescribing practices.

Caixi Hu, Xuemei Deng, Huachao Mai2026-11-01
🧬 biology

A Molecular characterization and virulence profiles of Staphylococcus aureus bloodstream infection and their associations with clinical prognosis: a comparative analysis of MSSA/MRSA and predominant ST188/ST398

This retrospective study of 81 Staphylococcus aureus bloodstream infection cases reveals that MRSA is an independent risk factor for poor prognosis and that the predominant clones ST188 (MSSA) and ST398 (mixed MSSA/MRSA) exhibit distinct virulence strategies characterized by differential biofilm formation, hemolytic activity, and unique patterns of exotoxin and protease gene retention or deletion.

Yun Zhou, Yanzi Chang, Chen Huang, Ximing Wang, Feng Wang, Hong Li2026-11-01
🧬 biology

mPTP sensitization and calcium channel remodeling: an adaptive response in carboplatin-resistant ovarian cancer cells

This study reveals that carboplatin-resistant ovarian cancer cells adapt to chemotherapy by initially sensitizing the mitochondrial permeability transition pore (mPTP) and subsequently downregulating calcium entry pathways to limit mitochondrial calcium overload, a mechanism linked to poor patient outcomes and suggesting that pharmacological attenuation of this sensitization could restore drug efficacy.

Olivier Romito, Ophélie Champion, Aude Lemettre, Mohamed Trebak, Caroline Goupille, Marie Potier-Cartereau2026-11-01
🧬 biology

Expression of Wnt-Related Long Non-coding RNAs ITGB2-AS1, HNF1A- AS1, and Lnc-MAP6-1:3 in Patients with Colorectal Cancer

This study demonstrates that the Wnt-related long non-coding RNAs ITGB2-AS1 and HNF1A-AS1 are significantly upregulated in colorectal cancer tissues and show promise as diagnostic biomarkers, whereas Lnc-MAP6-1:3 does not exhibit significant differential expression.

Paria Abedini, Iman Salahshoori Far, Mohammadmehdi Rajabpour, Seidamir Pasha Tabaeian, Atieh Akbari, Abolfazl Akbari2026-11-01