1390 papers
Baicalein ameliorates idiopathic pulmonary fibrosis by disrupting the HIF-1α/FHL2 phase-separated transcriptional hub, thereby suppressing the hypoxia-driven glycolytic shift and subsequent lactate-mediated histone lactylation that fuel fibrotic progression.
This study demonstrates that combining liver-directed lentiviral gene therapy with transient costimulatory blockade overcomes adaptive immune barriers to achieve durable therapeutic factor VIII expression, immune tolerance, and the ability to safely redose the therapy in a mouse model of hemophilia A.
This study reveals that host skin lipids trigger *Malassezia furfur* pathogenicity by activating a mating-type-dependent parasexual cycle that drives hyphal differentiation, enabling more efficient epidermal invasion and stronger inflammatory responses.
This study demonstrates that withdrawing WNT3a and TGFβ inhibitors in human gastric mucosoids drives differentiation into antral gland-like compartments with enhanced barrier and secretory functions, while cAMP signaling further modulates cell states and mucus proteome composition, establishing a versatile model for studying gastric epithelial biology.
This bibliometric analysis of 802 publications from 2016 to 2025 maps the rapid evolution of organoid and organ-on-a-chip research in diabetes and cardiovascular diseases, highlighting a paradigm shift toward high-fidelity disease modeling driven by the integration of bioprinting, single-cell omics, and artificial intelligence.
This study demonstrates that *Persicaria glabra* (Lal Kukri), a medicinal plant from Bangladesh, contains diverse phytochemicals and exhibits significant antioxidant, cytotoxic, and anti-inflammatory activities in its various solvent extracts, thereby validating its potential as a source of therapeutic compounds.
This study presents a physics-informed computational framework that integrates a modified density-dependent biofilm diffusion model with microfluidic observations to achieve superior forward prediction and inverse closure learning of pore-scale biofilm growth in porous media.
This metagenomics study from North-Eastern Algeria characterizes distinct urinary microbiome dysbiosis in prostate cancer and benign prostatic hyperplasia patients compared to controls, identifying specific microbial signatures and demonstrating how chemotherapy further disrupts this ecosystem, thereby suggesting the urinary microbiome as a promising non-invasive biomarker and therapeutic target for prostate diseases.
This study utilizes a large-scale, harmonized single-nucleus transcriptomic resource of the dorsolateral prefrontal cortex to demonstrate that while Major Depressive Disorder involves broad transcriptomic dysregulation and vascular-associated glial alterations, Bipolar Disorder is characterized by a distinct oligodendroglial signature and attenuated neuronal communication, revealing divergent cellular architectures that could inform future biological stratification of mood disorders.
Using dual-color in vivo fiber photometry in mice, this study reveals that while acute and repeated stress strengthen cortical neuron-astroglial functional coupling as an adaptive mechanism, chronic stress reverses this trajectory by sensitizing neuronal reactivity while blunting astroglial responses, leading to impaired coupling that coincides with the onset of depression-like behavioral deficits.