🧬 biology

AI Scientists for Building Virtual-Cell Models

The paper introduces CellForge, an autonomous multi-agent system that independently completes the full scientific cycle—from literature review and hypothesis formulation to code generation and validation—to build competitive virtual-cell models for predicting single-cell responses to perturbations without human intervention.

Mark Gerstein, Xiangru Tang, Jiapeng Chen, Yanjun Shao, Zhuoyun Yu, Yan Cui, Weixu Wang, Fang Wu, Yuxuan Liao, Yuchen Zh (…)2026-09-17
🧬 biology

Genomic Alterations Converge on Lipid Metabolism and ERBB2 in Breast Cancer.

This study integrates whole-genome sequencing and multi-omics data from 501 Indian breast cancer patients to reveal a lipid–ERBB2 axis, identifying novel genomic alterations and four distinct molecular states—including a poor-prognosis HER2–androgen-receptor subtype—that transcend traditional receptor classifications and link genomic diversity to clinical outcomes.

Shantanu Chowdhury, Divya Khanna, Arnab Ghosh, Priyanka Bhadwal, Ramakant Venkata, Leepakshi Dhingra, Subrata Das, Isha (…)2026-09-17
🧬 biology

Proteomic remodelling of human red blood cells and their extracellular vesicles across the intraerythrocytic cycle of Plasmodium falciparum

This study employs quantitative mass spectrometry to reveal that *Plasmodium falciparum* infection primarily remodels the protein composition of extracellular vesicles released by red blood cells—specifically by increasing complement components and parasite proteins—while causing only modest changes to the host cell's internal proteome, thereby supporting a model where infection-induced miRNAs function on recipient cells rather than within the infected red blood cell itself.

Nahla Galal Metwally2026-09-17
🧬 biology

WITHDRAWN: Microbiological Quality and Antimicrobial Resistance of Drinking and Reused Water Sources at Islamic University, Kushtia, Bangladesh

This preprint, which originally aimed to assess the microbiological quality and antimicrobial resistance of drinking and reused water sources at Islamic University in Kushtia, Bangladesh, has been withdrawn at the authors' request due to unauthorized use of underlying data and lack of proper attribution.

Arpita Nandi†, Sabbir Alam Zia†, Simonto Mirza, Afra Binte Iftekhar, Md Moshiur Rahman, Sarmin Shahnewaz, Abdulllah Al M (…)2026-09-17
🧬 biology

Fatty Acid Transport Proteins and Breast Cancer Risk by pathological subtype Novel Insights from Gene expression and Associations with Serum Fatty Acids

This study demonstrates that elevated serum long-chain fatty acid levels and upregulated expression of fatty acid transport proteins (FATPs) are significantly associated with breast cancer risk and vary across pathological subtypes, highlighting FATPs as potential biomarkers and therapeutic targets.

Ranjitha Acharya, Abhijith S Shetty, Flama Monteiro, Kishan Prasad H. L, Shilpa S Shetty, Suchetha Kumari N, Ashwini K (…)2026-09-17
🧬 biology

Hotspots and trends in Scorpion research: A visualization analysis

This study employs a bibliometric analysis of 2,918 publications from 2014 to 2025 to map global research trends, collaborative networks, and dominant themes in scorpion science, identifying key contributors and highlighting the field's focus on taxonomy and venom applications for therapeutic development.

Xuan Wu, Yifan Wang, Xi Liu, Jianfang Yang, Canwei Li, Yanqing Yang, Zizhong Yang, Hairong Zhao, Yu Zhao, Weihong Liu, C (…)2026-09-16
🧬 biology

A standardized, unbiased protocol for protected areas soundscape monitoring

This paper presents and validates a standardized, unbiased protocol for protected area soundscape monitoring that combines a spatially balanced design with a modular analytical workflow to generate reproducible, comparable baselines capable of detecting biologically and geophysically driven seasonal patterns.

Ivan Braga Campos, Sara Miranda Almeida, Maurício Carlos Martins Andrade, Laís C. G. Gomes, Thiago S. Gouvêa, Isabella R (…)2026-09-16