3724 papers
This study utilizes plasma proteomics in a large cohort of overweight individuals to demonstrate that obesity and type 2 diabetes are associated with a distinct systemic activation of ferroptosis-related pathways, characterized by elevated redox-responsive proteins and enriched oxidative stress mechanisms, with glycemic status showing a stronger link to these signatures than BMI.
This paper presents an open-source, adaptable platform that enables synchronized multimodal mapping of ex vivo hearts by integrating optical and electrical recordings with physiological monitoring and centralized control, thereby facilitating the study of complex arrhythmia mechanisms and the evaluation of cardiac mapping methods across various species and experimental configurations.
This study demonstrates that while overall spectral characteristics of neural activity during walking show few differences between treated Parkinson's disease patients and healthy controls, gait-phase-resolved analyses reveal distinct alterations in the temporal organization of cortical and subthalamic neural dynamics, suggesting that future biomarkers and neuromodulation strategies should prioritize capturing these dynamic patterns over average spectral magnitudes.
This study reveals that tumor-derived ST3GAL1 drives melanoma immune escape by stabilizing CD73 to boost adenosine production, which in turn recruits and activates immunosuppressive PMN-MDSCs while enhancing tumor cell chemokine secretion to create a suppressive tumor microenvironment.
This study demonstrates that the cytocompatibility and antibacterial efficacy of aqueous *Calendula officinalis* extracts against periodontal pathogens are highly dependent on the commercial source, revealing a trade-off where the Egyptian extract offers better host-cell safety while the Mi Granero extract provides stronger bacterial suppression.
This study reveals that neurotropic viral infections (including HCoV-229E, HCoV-OC43, and ZIKV) induce astrocyte remodeling characterized by collagen depletion, which increases viral susceptibility, while the LINC00460–miR-4443 regulatory axis modulates this process by controlling collagen abundance and astrocyte morphology.
This study demonstrates that autophagy is essential for the rapid reduction and remodeling of multiple organelles, including plastids, the endoplasmic reticulum, peroxisomes, and mitochondria, during *Arabidopsis* seed maturation to establish the intracellular state required for successful germination.
This study characterizes a novel, transferable integrative and conjugative element named ICEtea, which carries multidrug resistance genes and was identified in bovine mastitis-associated *Streptococcus uberis*, demonstrating its ability to spread across diverse Gram-positive bacteria and highlighting the need for cross-species surveillance of mobile resistance elements.
This study reveals that while BCMA antigen loss via TNFRSF17 alterations is uncommon in multiple myeloma patients progressing after BCMA-directed therapies, resistance is frequently driven by the acquisition or clonal enrichment of pathogenic variants in NF-κB, PI3K-AKT-mTOR, and MAPK/ERK survival pathways alongside TP53 mutations, representing a major antigen-loss-independent mechanism of treatment failure.
This study reveals that paper currency in Chattogram, Bangladesh, serves as a significant reservoir for multidrug-resistant Gram-negative bacteria, particularly *Klebsiella pneumoniae*, *Escherichia coli*, and *Pseudomonas aeruginosa*, which exhibit high resistance to common antibiotics and pose a public health risk requiring improved hygiene and stewardship.