5759 papers
This study demonstrates that failing to adjust for blast percentage in the Beat AML dataset significantly confounds transcriptome-drug response associations, as evidenced by the substantial loss of statistical significance for markers like DHODH and sorafenib when blast content is included in the analysis.
This study demonstrates that specific MBL2 exon 1 and promoter variants are differentially associated with cytomegalovirus seropositivity in acute lymphoblastic leukemia patients and controls from the Brazilian Amazon, with structural modeling suggesting these genetic changes destabilize the MBL protein and impair its function.
This study reveals that large, solitary deep-sea predators exhibit extraordinary reproductive strategies by concentrating millions of eggs into specific, geothermal-influenced seamount summits, where females actively select habitats across nested spatial scales for potentially decade-long incubation.
This multi-omics and machine learning study reveals that atherosclerosis and diabetic foot ulcers share a common senescence-related molecular signature characterized by three core genes (CALCOCO1, CCND2, and FUCA1), which serve as robust diagnostic biomarkers and suggest metformin as a potential therapeutic agent for mitigating cellular senescence in these conditions.
This reanalysis of public microarray data found that apparent transcriptomic overlap between major depressive disorder and experimental sleep restriction is highly sensitive to analytical choices and failed to establish a statistically significant shared blood signature after false discovery rate control.
This study demonstrates that androgen receptor expression in triple-negative breast cancer defines a distinct, low-proliferative molecular subtype characterized by specific genomic alterations, enhanced TGFβ signaling, and a unique immune microenvironment, although it does not independently predict patient survival.
This study demonstrates that while single-cell-derived myeloid and fibroblast/stromal transcriptional programs maintain detectable within-lineage coherence and positive bulk correlations across external bladder cancer datasets, their transportability is representation-dependent and fails to preserve discrete cellular states, specific axes, or cellular interactions.
This study demonstrates that expert-curated data, the inclusion of invaded-range records, and the use of invasion-specific evaluation metrics are critical for improving the accuracy and policy relevance of species distribution models used to assess the early invasion risk of citrus psyllid vectors.
This study demonstrates that the loss of CD2 expression in systemic mastocytosis promotes a diffuse, leukemic organ invasion mediated by E- and P-selectins, leading to significantly reduced patient survival compared to CD2-positive disease.
This study demonstrates that resting-state EEG theta-band functional connectivity profiles not only correlate with specific IGD symptoms like mood modification but also reveal neurophysiological heterogeneity within the disorder that is distinct from traditional symptom severity or gaming frequency measures.