1390 papers
This study characterizes BhEstB, a highly promiscuous *Bacillus halotolerans* esterase that, despite lacking typical PET-binding motifs and showing modest bulk polymer activity, exhibits exceptional efficiency in degrading PET intermediates (BHET and MHET), thereby establishing a new structural blueprint for enzymes transitioning from intermediate processing to true polymer degradation.
This study reveals that the prokaryotic actin homolog MreB undergoes continuous nucleotide exchange within its filaments to regulate stability, a mechanism distinct from canonical actin and tubulin where such exchange occurs only in soluble subunits.
This study establishes and validates a 15-gene copper and lipid metabolism-related prognostic signature for gastric cancer that effectively stratifies patient risk, correlates with distinct metabolic subtypes and immune microenvironment features, and identifies GAD1 as a key driver of tumor progression.
This study demonstrates that anting behavior in the Japanese thrush (*Turdus cardis*) provides adaptive advantages by chemically altering the bird's plumage with the ant-specific compound dendrolasin, which effectively repels and removes ectoparasites like louse flies and dipteran insects, thereby offering protection against vector-borne diseases such as avian malaria.
This paper introduces Pantanal Bioacoustics v2, a reproducible data infrastructure integrating taxonomic references, continental occurrence records, and 11,785 validated audio recordings with 77 acoustic descriptors to support biodiversity monitoring and research in the Pantanal wetlands.
By integrating cortical abnormality maps from six psychiatric disorders with brain immune gene expression data, this study identifies distinct microglia- and T-cell-related transcriptional vulnerability clusters that underlie regional cortical abnormalities and reveal disorder-specific neuroimmune mechanisms.
This study reveals that target RNA abundance acts as a critical threshold governing the collateral RNA cleavage activity of RfxCas13d, causing global toxicity in human cells and zebrafish embryos when targets are highly expressed, while identifying guide-target mismatches that can mitigate this off-target effect without compromising on-target silencing.
This study presents the first comprehensive whole-genome resequencing analysis of a multi-generational captive Sunda pangolin population in Guangxi, revealing strong purifying selection and ribosome pathway enrichment while providing essential genomic resources to optimize breeding strategies and mitigate genetic decline in conservation programs.
This study characterizes TsATG4B from *Trichinella spiralis* as a functional C54 cysteine protease that facilitates larval intestinal invasion by degrading host structural and immune molecules and disrupting epithelial tight junction barriers, offering a potential target for novel trichinellosis interventions.
This study demonstrates that TRAIL deficiency exacerbates experimental colitis in mice by impairing the differentiation of resident macrophages and promoting a pro-inflammatory phenotype, suggesting that TRAIL plays a critical role in maintaining intestinal immune homeostasis and represents a potential therapeutic target for inflammatory bowel disease.