1390 papers
This study presents a high-accuracy machine learning model for classifying eight microorganisms and introduces a novel synthesis of Al₂O₃-stabilized tetragonal and cubic ZrO₂ nanoparticles as a biocompatible nanocarrier for antimicrobial drug delivery.
By employing a full factorial design to map carbon source interactions across seven bacterial species, this study demonstrates that while individual nutrients can exhibit context-dependent negative effects due to global epistasis, bacterial growth in complex environments is predominantly driven by additive and pairwise effects, enabling accurate prediction and rational optimization of growth conditions through simple statistical models.
This study identifies adenylosuccinate (AdSucc) as a novel pro-angiogenic signaling molecule that accumulates during ischemia and promotes blood vessel formation both in vivo and in vitro, potentially serving as an adaptive mechanism to low-energy conditions.
Using structured participatory interviews across high-altitude Arunachal Pradesh, India, this study reveals that while large carnivores maintain near-universal ranges, community knowledge indicates a convergent decline in the abundance of tigers, snow leopards, and leopards driven by livestock conflict, highlighting local ecological knowledge as a cost-effective tool for early detection of population changes.
This multi-omics study reveals that p-hydroxybenzoic acid enhances the pathogenicity of *Fusarium oxysporum* by significantly upregulating beauvericin production and conidiospore formation through the modulation of amino acid metabolism pathways, while simultaneously inhibiting fusaric acid synthesis.
ScaleComm is a graph-wavelet framework that infers ligand-receptor-specific spatial communication by learning distinct effective spatial scales and context features for each pair, thereby improving the accuracy and biological relevance of cell-cell interaction detection in spatial transcriptomics data.
This multi-omics study reveals that psychological stress exacerbates acid reflux esophageal injury not by increasing gastric acid or bile secretion, but by disrupting hypothalamic lipid metabolism to inhibit the PPAR signaling pathway via targets NCOA3 and NR1D2, thereby compromising the esophageal mucosal barrier.
This study demonstrates that while immunosuppressive drugs generally do not cause acute toxicity to human fetal kidney organotypic cultures at biologically relevant concentrations, high doses of cyclosporine significantly impair cell viability and differentiation, and all tested agents warrant further investigation regarding their potential impact on renin-positive cells and long-term renal development.
This study demonstrates that coal-derived carbon accumulation in cropland soils actively reshapes microbial functional potential and drives shifts in carbon, nitrogen, and phosphorus cycling processes, rather than acting as a passive component of soil organic matter.
This study reveals that phagosomal acidification in macrophages drives a lipid–redox program that promotes antibiotic tolerance in *Mycobacterium tuberculosis*, and demonstrates that chloroquine-mediated alkalinization disrupts this pathway to enhance bacterial clearance when combined with standard antibiotics.