5759 papers
This study utilizes multimodal imaging to demonstrate that spinal glymphatic transport is regulated by anatomical constraints, tracer properties, and administration route, and reveals that spinal cord injury disrupts tissue clearance despite accelerated tracer propagation, a dysfunction exacerbated by aquaporin-4 loss that correlates with increased lesion severity and motor impairment.
This study reveals that *Cutibacterium acnes* promotes chronic prosthetic joint infections by engaging in a contact-dependent interaction with *Staphylococcus lugdunensis* that triggers a metabolic shift toward polysaccharide intercellular adhesin (PIA)-rich biofilm formation, thereby enhancing bacterial persistence on medical devices.
This study demonstrates that analyzing differential gene expression, including WGCNA and RNA velocity from a single early blood sample, can predict immune trajectories and endotype transitions in children with septic shock, thereby identifying potential treatable traits for improving outcomes.
This study reveals that edematous severe acute malnutrition is associated with profound hypomethylation of the protocadherin gamma (PCDHG) gene cluster, providing a novel epigenetic mechanism that links early-life malnutrition to both neurodevelopmental impairment and physical barrier dysfunction.
This study demonstrates that pathogen-driven preterm prelabour rupture of the fetal membranes (PPROM) is likely more common than previously thought, as spatial analysis reveals a high prevalence of bacterial colonization in fetal membranes and elevated inflammatory markers in PPROM patients, often originating from the vagina even when a Lactobacillus-dominated vaginal microbiome is present.
Although clinical antibiotic therapy disrupts microbial bile acid metabolism and depletes secondary bile acids, this specific metabolic perturbation does not appear to mediate the impaired pulmonary antibacterial defense observed in patients.
This study identifies a distinct KRT17⁺/GATA6⁺ hybrid cell state in pancreatic cancer that drives metastasis and therapy resistance through a MYC-dependent program, revealing a specific therapeutic vulnerability to MYC inhibition in this aggressive phenotype.
Cryo-EM analysis of AA amyloid deposits from a cat's heart, liver, and kidney revealed unprecedented structural heterogeneity with nine distinct assemblies exhibiting tissue-specific preferences, suggesting that local microenvironments drive independent aggregation pathways rather than inter-organ seeding.
CortexQ presents a computational framework that integrates pathway forecasting, structural dynamics, and disproof-conditioned reasoning across molecular scales to predict immune escape and guide intervention strategies in colorectal and endometrial cancers, demonstrating preliminary component progress while acknowledging the need for further validation of its integrated predictive superiority and quantum advantages.
This study demonstrates that carotid Doppler waveforms contain explainable age-related information, particularly through the Velocity Reflection Index, while highlighting that combining multiple feature importance methods with ablation analysis is essential to avoid overstating the unique contribution of highly correlated biomarkers in machine learning models.