3724 papers
This study demonstrates that while voluntary action enhances perceptual sensitivity in self-other discrimination, it does not correspondingly improve metacognitive monitoring, suggesting these two processes rely on partially independent mechanisms.
This study characterizes the immunological signatures of fractionated excretory–secretory products from adult *Fasciola hepatica*, revealing a layered immune evasion strategy involving extracellular vesicles, specific IL-10 induction, and broad cytokine suppression that informs future diagnostic and vaccine development.
This paper utilizes the Modified Involuted Manifold Model (MIMM) to bridge the gap between neurological and cognitive frameworks, proposing that cognitive functions act as an environment for the natural selection of neuronal organization to better understand and treat plasticity across developmental, geriatric, and post-traumatic contexts.
This study presents an integrated AI-physics screening pipeline that identified two structurally novel, drug-like candidate compounds (ZINC9412756 and ZINC20724474) with high predicted affinity for dual MDM2/MDM4 inhibition, offering a promising therapeutic strategy for dedifferentiated liposarcoma pending experimental validation.
This study identifies the ZNF460–SNRPB–RDM1 splicing axis as a key driver of genomic instability and therapeutic vulnerability in clear cell renal cell carcinoma, where ZNF460-mediated overexpression of SNRPB disrupts RDM1 splicing to impair homologous recombination repair and sensitize tumors to PARP inhibition.
This paper presents a machine-readable database aggregating published literature on FKTN-related congenital muscular dystrophies, featuring harmonized genotype-phenotype data and a new clinical severity scale to facilitate genotype-phenotype correlation and serve as a pilot for similar rare disease analyses.
This study reveals that freshwater and marine piscicolid leeches possess distinct repertoires of hirudin-like anticoagulants, including species-specific ornatins and hirudin-like factors alongside a newly identified, evolutionarily conserved group of "piscicolins," suggesting that the ancestral hirudin superfamily gene was already present at the origin of true leeches.
This study utilizes homology modeling and molecular dynamics simulations to identify the flavonols kaempferol and quercetin as promising, non-toxic candidates for inhibiting litchi polyphenol oxidase and preventing postharvest browning, while highlighting that their transient binding suggests a need for agents with more durable engagement.
This study demonstrates that a Canadian pine bark extract (CPBE) ameliorates mitochondrial dysfunction, oxidative stress, and cellular damage in human cardiomyocyte-like cells subjected to either insulin-resistant senescence or β-adrenergic stress by restoring mitochondrial redox homeostasis and metabolic balance.
This study on domestic canaries reveals that the transgenerational transmission of maternal aggression depends specifically on direct mother-daughter interactions during rearing, rather than on genetic inheritance, prenatal effects, or the postnatal environment alone.